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Roles of Plasminogen Activator Inhibitor-1 in Heterotopic Ossification Induced by Achilles Tenotomy in Thermal Injured Mice
Heterotopic ossification (HO) is the process by which ectopic bone forms at an extraskeletal site. Inflammatory conditions induce plasminogen...
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Pattern formation in Passiflora incarnata: An activator-inhibitor model
AbstractBased on a careful examination of the onset of violet colored dots along the filaments in the develo** floral bud stage and the formation...
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mTOR signaling pathway regulation HIF-1 α effects on LPS induced intestinal mucosal epithelial model damage
BackgroundSepsis-induced small-intestinal injury is associated with increased morbidity and mortality. Our previous study and other papers have shown...
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The DNA Methyltransferase Inhibitor RG108 is Converted to Activator Following Conjugation with Short Peptides
We report serendipitous findings within a wider effort to design and characterize novel derivatives of the DNA methyltransferase inhibitor RG108...
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Urokinase plasminogen activator as an anti-metastasis target: inhibitor design principles, recent amiloride derivatives, and issues with human/mouse species selectivity
The urokinase plasminogen activator (uPA) is a widely studied anticancer drug target with multiple classes of inhibitors reported to date. Many of...
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Molecular transformations and self-association in anthocyanin pigment patterns
Spatial patterns of red, purple, and blue colors due to plant pigments called anthocyanins appear in a wide variety of flower petals. Activator and...
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Bone marrow mesenchymal stem cell-derived exosomes promote plasminogen activator inhibitor 1 expression in vascular cells in the local microenvironment during rabbit osteonecrosis of the femoral head
BackgroundNontraumatic osteonecrosis of the femoral head (NONFH) is a highly disabling orthopedic disease in young individuals. Plasminogen activator...
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Yes-associated protein (YAP) induces a secretome phenotype and transcriptionally regulates plasminogen activator Inhibitor-1 (PAI-1) expression in hepatocarcinogenesis
BackgroundOverexpression and nuclear enrichment of the oncogene yes-associated protein (YAP) cause tumor initiation and support tumor progression in...
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HSP70 attenuates neuronal necroptosis through the HSP90α-RIPK3 pathway following neuronal trauma
BackgroundNecroptosis, a newly defined regulatable necrosis with membrane disruption, has been demonstrated to participate in trauma brain injury...
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NMDARs activation regulates endothelial ferroptosis via the PP2A-AMPK-HMGB1 axis
N-methyl-D-aspartate receptors (NMDARs) are ligand-gated, voltage-dependent channels of the ionotropic glutamate receptor family. The present study...
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Possible role of combined therapy targeting MET and pro-HGF activation for renal cell carcinoma: analysis by human HGF-producing SCID mice
MET is a high-affinity receptor tyrosine kinase of HGF (hepatocyte growth factor). HGF is secreted as an inactive single-chain precursor (pro-HGF),...
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Sestrin2 ameliorates diabetic retinopathy by regulating autophagy and ferroptosis
Diabetic retinopathy (DR) is a serious microvascular complication of diabetes. The aim of this study was to explore the effect of Sestrin2 on DR...
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The endonuclease FEN1 mediates activation of STAT3 and facilitates proliferation and metastasis in breast cancer
BackgroundThe metastasis accounts for most deaths from breast cancer (BRCA). Understanding the molecular mechanisms of BRCA metastasis is urgently...
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Zebrafish As a Promising Experimental Model of Traumatic Brain Injury
AbstractTraumatic brain injury (TBI) involves multiple types of physical brain lesions. TBI is a highly heterogeneous clinical condition whose...
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Lipid droplet accumulation in Wdr45-deficient cells caused by impairment of chaperone-mediated autophagic degradation of Fasn
Backgroundβ-Propeller protein-associated neurodegeneration (BPAN) is a genetic neurodegenerative disease caused by mutations in WDR45 . The...
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A large-scale Boolean model of the rheumatoid arthritis fibroblast-like synoviocytes predicts drug synergies in the arthritic joint
Rheumatoid arthritis (RA) is a complex autoimmune disease with an unknown aetiology. However, rheumatoid arthritis fibroblast-like synoviocytes...
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Liver organoids: an in vitro 3D model for liver cancer study
Primary liver cancer (PLC) is the second leading cause of cancer mortality worldwide, and its morbidity unceasingly increases these years. Hepatitis...
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Suppressed Akt/GSK-3β/β-catenin signaling contributes to excessive adipogenesis of fibro-adipogenic progenitors after rotator cuff tears
Muscular fatty infiltration is a common and troublesome pathology after rotator cuff tears (RCT), which mainly derives from fibro-adipogenic...
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PEDF protects retinal pigment epithelium from ferroptosis and ameliorates dry AMD-like pathology in a murine model
Age-related macular degeneration (AMD) is the leading cause of irreversible vision damage among elderly individuals. There is still no efficient...
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Lentinan mitigates pemetrexed chemoresistance by the PI3K/Akt pathway in non-small cell lung cancer
Pemetrexed is a folate analog metabolic inhibitor that is given for therapy of non-small cell lung cancer (NSCLC). Drug resistance affects the...
