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Chimeric antigen receptor-based natural killer cell immunotherapy in cancer: from bench to bedside
Immunotherapy has rapidly evolved in the past decades in the battle against cancer. Chimeric antigen receptor (CAR)-engineered T cells have...
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Single-cell characterization of self-renewing primary trophoblast organoids as modeling of EVT differentiation and interactions with decidual natural killer cells
BackgroundExtravillous trophoblast cell (EVT) differentiation and its communication with maternal decidua especially the leading immune cell type...
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Natural killer cells in the central nervous system
Natural killer (NK) cells are essential components of the innate lymphoid cell family that work as both cytotoxic effectors and immune regulators....
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Chimeric antigen receptor-natural killer cells: a promising sword against insidious tumor cells
Natural killer (NK) cells are a critical component of innate immunity, particularly in initial cancer recognition and inhibition of additional tumor...
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MiR-30c facilitates natural killer cell cytotoxicity to lung cancer through targeting GALNT7
BackgroundMicroRNAs (miRNAs) have been reported to play important roles in regulating natural killer (NK) cell cytotoxicity to cancer cells.
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Reconstitution of Natural Killer cells after allogeneic hematopoietic stem cell transplantation is facilitated by Huiyang-Guben decoction through activating the Smad7/Stat3 signal pathway
Natural Killer (NK) cell is the first batch of re-constructed cell populations after allogeneic hematopoietic stem cell transplantation (allo-HSCT),...
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Natural killer cells and their exosomes in viral infections and related therapeutic approaches: where are we?
Innate immunity is the first line of the host immune system to fight against infections. Natural killer cells are the innate immunity lymphocytes...
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Natural killer cell awakening: unleash cancer-immunity cycle against glioblastoma
Due to the negligence of the complex tumor immune microenvironment, traditional treatment for glioblastoma has reached its limitation and cannot...
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Caspase Activation in Trophoblast Cells after Interacting with Microparticles Produced by Natural Killer Cells in vitro
AbstractIntercellular communication plays a huge role in the vital activity of living organisms. At present, far less studied is distant cellular...
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Interconnected lineage trajectories link conventional and natural killer (NK)-like exhausted CD8+ T cells beneficial in type 1 diabetes
Distinct Natural Killer (NK)-like CD57 + and PD-1 + CD8 + exhausted-like T cell populations (Tex) have both been linked to beneficial immunotherapy...
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The role of exhausted natural killer cells in the immunopathogenesis and treatment of leukemia
The immune responses to cancer cells involve both innate and acquired immune cells. In the meantime, the most attention has been drawn to the...
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Challenges of chimeric antigen receptor-T/natural killer cell therapy in the treatment of solid tumors: focus on colorectal cancer and evaluation of combination therapies
Colorectal cancer (CRC) is the second most common cancer globally and one of the deadliest human malignancies. Traditional therapies, such as...
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Development and validation a prognostic model based on natural killer T cells marker genes for predicting prognosis and characterizing immune status in glioblastoma through integrated analysis of single-cell and bulk RNA sequencing
BackgroundGlioblastoma (GBM) is an aggressive and unstoppable malignancy. Natural killer T (NKT) cells, characterized by specific markers, play...
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Infiltrating natural killer cells bind, lyse and increase chemotherapy efficacy in glioblastoma stem-like tumorospheres
Glioblastomas remain the most lethal primary brain tumors. Natural killer (NK) cell-based therapy is a promising immunotherapeutic strategy in the...
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Cytokine-induced memory-like natural killer cells for cancer immunotherapy
Natural killer cells are an important part of the innate immune system mediating robust responses to virus-infected and malignant cells without...
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Pediatric multicellular tumor spheroid models illustrate a therapeutic potential by combining BH3 mimetics with Natural Killer (NK) cell-based immunotherapy
The induction of apoptosis is a direct way to eliminate tumor cells and improve cancer therapy. Apoptosis is tightly controlled by the balance of...
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Mesenchymal stem cells and natural killer cells interaction mechanisms and potential clinical applications
Natural killer cells (NK cells) are innate immune cells that are activated to fight tumor cells and virus-infected cells. NK cells also play an...
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Rac1/ROCK-driven membrane dynamics promote natural killer cell cytotoxicity via granzyme-induced necroptosis
BackgroundNatural killer (NK) cells play an important role in cancer immunosurveillance and therapy. However, the target selectivity of NK cell...
