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Jasmonates and Histone deacetylase 6 activate Arabidopsis genome-wide histone acetylation and methylation during the early acute stress response
BackgroundJasmonates (JAs) mediate trade-off between responses to both biotic and abiotic stress and growth in plants. The Arabidopsis thaliana ...
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Organ-specific characteristics govern the relationship between histone code dynamics and transcriptional reprogramming during nitrogen response in tomato
Environmental stimuli trigger rapid transcriptional reprogramming of gene networks. These responses occur in the context of the local chromatin...
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Histone Ubiquitylation and the Regulation of Transcription
The small (76 amino acids) and highly conserved ubiquitin protein plays key roles in the physiology of eukaryotic cells. Protein ubiquitylation...
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Readout of histone methylation by Trim24 locally restricts chromatin opening by p53
The genomic binding sites of the transcription factor (TF) and tumor suppressor p53 are unusually diverse with regard to their chromatin features,...
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Dysregulation of histone modifications in bone marrow mesenchymal stem cells during skeletal ageing: roles and therapeutic prospects
Age-associated bone diseases such as osteoporosis (OP) are common in the elderly due to skeletal ageing. The process of skeletal ageing can be...
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Histone modification landscape and the key significance of H3K27me3 in myocardial ischaemia/reperfusion injury
Histone modifications play crucial roles in the pathogenesis of myocardial ischaemia/reperfusion (I/R) injury. However, a genome-wide map of histone...
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Diet-Induced Histone Modifications: Implications for Human Health and Diseases
Post-translational modifications of histones (PTMs) are key epigenetic regulators and control chromatin-mediated processes such as gene expression,...
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Histone H1.0 couples cellular mechanical behaviors to chromatin structure
Tuning of genome structure and function is accomplished by chromatin-binding proteins, which determine the transcriptome and phenotype of the cell....
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The mechanisms, regulations, and functions of histone lysine crotonylation
Histone lysine crotonylation (Kcr) is a new acylation modification first discovered in 2011, which has important biological significance for gene...
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Defining super-enhancers by highly ranked histone H4 multi-acetylation levels identifies transcription factors associated with glioblastoma stem-like properties
BackgroundSuper-enhancers (SEs), which activate genes involved in cell-type specificity, have mainly been defined as genomic regions with top-ranked...
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Diverse and dynamic forms of gene regulation by the S. cerevisiae histone methyltransferase Set1
Gene transcription is an essential and highly regulated process. In eukaryotic cells, the structural organization of nucleosomes with DNA wrapped...
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Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2
Histone lysine crotonylation is a posttranslational modification with demonstrated functions in transcriptional regulation. Here we report the...
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Structural basis of the histone ubiquitination read–write mechanism of RYBP–PRC1
Histone H2A monoubiquitination (H2Aub1) by the PRC1 subunit RING1B entails a positive feedback loop, mediated by the RING1B-interacting protein RYBP....
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Resetting histone modifications during human prenatal germline development
Histone modifications play critical roles in regulating gene expression and present dynamic changes during early embryo development. However, how...
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N(alpha)-acetyltransferase 40-mediated histone acetylation plays an important role in ecdysone regulation of metamorphosis in the red flour beetle, Tribolium castaneum
Histone acetylation, a crucial epigenetic modification, is governed by histone acetyltransferases (HATs), that regulate many biological processes....
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Histone FRET reports the spatial heterogeneity in nanoscale chromatin architecture that is imparted by the epigenetic landscape at the level of single foci in an intact cell nucleus
Genome sequencing has identified hundreds of histone post-translational modifications (PTMs) that define an open or compact chromatin nanostructure...
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Iron drives anabolic metabolism through active histone demethylation and mTORC1
All eukaryotic cells require a minimal iron threshold to sustain anabolic metabolism. However, the mechanisms by which cells sense iron to regulate...
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Ovulatory signal-triggered chromatin remodeling in ovarian granulosa cells by HDAC2 phosphorylation activation-mediated histone deacetylation
BackgroundEpigenetic reprogramming is involved in luteinizing hormone (LH)-induced ovulation; however, the underlying mechanisms are largely unknown.
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Investigating Histone Modification Dynamics by Mechanistic Computational Modeling
The maintenance of transcriptional states regulated by histone modifications and controlled switching between these states are fundamental concepts...
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Detection and Quantification of Histone Methyltransferase Activity In Vitro
Histone methyltransferases (HMTs) catalyze the methylation of lysine and arginine residues in histone as well as nonhistone substrates. In vitro...