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Dimeric ACE2-FC Is Equivalent to Monomeric ACE2 in the Surrogate Virus Neutralization Test
AbstractAngiotensin-converting enzyme 2 (ACE2) is the main cellular receptor for the dangerous sarbecoviruses SARS-CoV and SARS-CoV-2. Its...
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Spike-and-ACE2 Binding with 100 Drugs
Durdagi (All atom 500-nano seconds molecular dynamics simulations of SARS-CoV-2 spike receptor-binding domain bound with ACE2 (Version 2) [Data set]....
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Human ACE2 Ectodomain Binding with 78 Drugs
Shaw et al. (2020) selected 5152 drug molecules from the FDA drug library and found that during 2...
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ACE2 mediates tryptophan alleviation on diarrhea by repairing intestine barrier involved mTOR pathway
The membrane-delimited receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), angiotensin-converting enzyme 2 (ACE2), which is...
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Determinants of species-specific utilization of ACE2 by human and animal coronaviruses
Utilization of human ACE2 allowed several bat coronaviruses (CoVs), including the causative agent of COVID-19, to infect humans directly or via...
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Extrinsic stabilization of antiviral ACE2-Fc fusion proteins targeting SARS-CoV-2
The angiotensin-converting enzyme 2 (ACE2) is a viral receptor used by sarbecoviruses to infect cells. Fusion proteins comprising extracellular ACE2...
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Human ACE2, Human IL6, Human IL6R, and Human nAChRs
SARS-CoV-2, the virus causing the COVID-19 global pandemic, encodes for a trimeric spike glycoprotein that contains a receptor-binding domain (RBD)...
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ACE2 inhibits proliferation of smooth muscle cell through AT1R and its downstream signaling pathway
To investigate the effect of the angiotensin converting enzyme 2 (ACE2) on AT1R expression, ERK1/2 and STAT3 protein phosphorylation in rat vascular...
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Broad host tropism of ACE2-using MERS-related coronaviruses and determinants restricting viral recognition
Recently, two Middle East respiratory syndrome coronavirus (MERS-CoV) closely related to bat merbecoviruses, NeoCoV and PDF-2180, were discovered to...
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ACE2-dependent and -independent SARS-CoV-2 entries dictate viral replication and inflammatory response during infection
Excessive inflammation is the primary cause of mortality in patients with severe COVID-19, yet the underlying mechanisms remain poorly understood....
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Immune evasion and ACE2 binding affinity contribute to SARS-CoV-2 evolution
Mutations in the SARS-CoV-2 genome could confer resistance to pre-existing antibodies and/or increased transmissibility. The recently emerged Omicron...
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The effect of zofenopril on the cardiovascular system of spontaneously hypertensive rats treated with the ACE2 inhibitor MLN-4760
BackgroundAngiotensin converting enzyme 2 (ACE2) plays a crucial role in the infection cycle of SARS-CoV-2 responsible for formation of COVID-19...
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Genetic analysis of ACE2 peptidase domain in SARS-CoV-2-positive and SARS-CoV-2-negative individuals from Pakistan
BackgroundThe outbreak of coronavirus disease 2019 (COVID-19) has emerged as a serious public health emergency of global concern. Angiotensin...
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Multimeric ACE2-IgM fusions as broadly active antivirals that potently neutralize SARS-CoV-2 variants
Coronavirus infections are a world-wide threat to human health. A promising strategy to develop a broadly active antiviral is the use of fusion...
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A computationally designed ACE2 decoy has broad efficacy against SARS-CoV-2 omicron variants and related viruses in vitro and in vivo
SARS-CoV-2, especially B.1.1.529/omicron and its sublineages, continues to mutate to evade monoclonal antibodies and antibodies elicited by...
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Implications of SARS-CoV-2 spike protein interactions with Zn-bound form of ACE2: a computational structural study
The COVID-19 pandemic has generated a major interest in designing inhibitors to prevent SARS-CoV-2 binding on host cells to protect against...
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Interactions of angiotensin-converting enzyme-2 (ACE2) and SARS-CoV-2 spike receptor-binding domain (RBD): a structural perspective
BackgroundSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused millions of infections and deaths worldwide since its discovery in...
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Association investigations between ACE1 and ACE2 polymorphisms and severity of COVID-19 disease
Due to the unique affinity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to the angiotensin-converting enzyme 2 (ACE2) receptor...
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ACE2 deficiency exacerbates obesity-related glomerulopathy through its role in regulating lipid metabolism
Obesity-related glomerulopathy is a secondary glomerular disease and its incidence has been increased globally in parallel with the obesity epidemic....
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Suramin binds and inhibits infection of SARS-CoV-2 through both spike protein-heparan sulfate and ACE2 receptor interactions
SARS-CoV-2 receptor binding domains (RBDs) interact with both the ACE2 receptor and heparan sulfate on the surface of host cells to enhance...
