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Enhanced production of 5-hydroxytryptophan through the regulation of L-tryptophan biosynthetic pathway
5-Hydroxytryptophan (5-HTP) is the precursor of the neurotransmitter serotonin and has been used for the treatment of various diseases such as...
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Structural and Functional Analyses of the Flavoprotein Disulfide Reductase FN0820 of Fusobacterium nucleatum
Escherichia coli RclA and Staphylococcus aureus MerA are part of the Group I flavoprotein disulfide reductase (FDR) family and have been implicated...
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Simultaneous determination of l-tryptophan impurities in meat products
L-tryptophan has been used as a feed additive for swine and poultry and as a nutrient supplement for humans. However, some impurities in l -tryptophan...
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Asperosaponin VI Protects Against Bone Loss Due to Hindlimb Unloading in Skeletally Growing Mice Through Regulating Microbial Dysbiosis Altering the 5-HT Pathway
Osteoporosis is a complex multifactorial disease that can lead to an increased risk of fracture. However, selective and effective osteoporosis drugs...
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Lactobacillus rhamnosus GG normalizes gut dysmotility induced by environmental pollutants via affecting serotonin level in zebrafish larvae
Intestinal peristalsis is essential for gastrointestinal function, which could maintain the appropriate progression and digestion of food and reduce...
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Serotonin modulates insect gut bacterial community homeostasis
BackgroundMetazoan guts are in permanent contact with microbial communities. However, the host mechanisms that have developed to manage the dynamic...
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Abiotic Stress-Induced Modulation of Melatonin Biosynthesis Accompanying Phytohormonal Crosstalk in Plants
Initially identified as a potent regulator in animals, melatonin is a multifunctional molecule that regulates versatile physiological and...
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Melatonin Discovery and Divergent Biosynthetic Pathways in Plants
Despite the fact that we all know that melatonin plays a role and has some profound effects on animals, recent studies have shown that this...
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Pulmonary embolism and 529 human blood metabolites: genetic correlation and two-sample Mendelian randomization study
BackgroundThe incidence of pulmonary embolism complications in the literature ranges from 10 to 50%, with a 0.5–10% risk of fatal pulmonary embolism....
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Effects of Selenium on Serotonin Synthesis and the Glutathione Redox Cycle in Plum Leaves
Selenium (Se), an essential micronutrient for humans, is also a beneficial nutrient for growth and development of many plants. The aim of the present...
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Advances in the microbial synthesis of the neurotransmitter serotonin
AbstractSerotonin, as a monoamine neurotransmitter, modulates the activity of the nervous system. Due to its importance in the coordination of...
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Physiological and Molecular Mechanisms of Melatonin-Induced Tolerance to Heavy Metal Stress
Rapid development of the industry has increased the risk of environmental pollution, especially heavy metal pollution. When the crop uptakes large...
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Two-Dimensional Thin Layer Chromatography of Melatonin and Related Compounds
Two-dimensional thin layer chromatography has been used by workers in the field to separate radiolabeled serotonin derivatives from complex mixtures...
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Melatonin in Plants: Biosynthesis, Occurrence and Role in plants
Melatonin (N-acetyl-5-methoxytryptamine) is a pineal gland hormone, relatively little research has been done on it in this area up until 1995. It can...
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Potential, Mechanism and Molecular Insight of Melatonin in Phyto-Remediation
Melatonin act as a plant growth stimulator under plant stress condition. Various factors induce stress on plants like heavy metals accumulation, salt...
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Interrogation of the mammalian gut–brain axis using LC–MS/MS-based targeted metabolomics with in vitro bacterial and organoid cultures and in vivo gnotobiotic mouse models
Interest in the communication between the gastrointestinal tract and central nervous system, known as the gut–brain axis, has prompted the...
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Synthesis of Biogenic Amines by Lactic Acid Bacteria on Media of Plant and Animal Origin
Abstract —The intestinal microbiota is known to perform an important role in terms of the host organism’s metabolism and life-sustaining activities....
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Action of Serotonin Precursor Synthesis 5-Oxytryptophan on EPSP Recorded in Premotor Interneurons of Snail after Formation of Conditioned Defensive Reflex
AbstractA quantitative study of subthreshold excitatory postsynaptic potentials (EPSP) recorded intracellularly in giant premotor interneurons of the...
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Unusual concurrence of P-solubilizing and biocontrol traits under P-limitation in plant-beneficial Pseudomonas aeruginosa P4: insights from in vitro metabolic and gene expression analysis
Plant-beneficial fluorescent Pseudomonas species with concurrent P-solubilizing and biocontrol traits could have improved rhizospheric survival and...
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Indoleamine-2,3 dioxygenase: a fate-changer of the tumor microenvironment
Indoleamine-2,3 dioxygenase is a rate-limiting enzyme in the tryptophan catabolism in kynurenine pathways that has an immunosuppressive effect and...
