Search
Search Results
-
Efficient Synthesis, Reactions and Anti-Inflammatory Evaluation of Novel Cyclopenta[d]thieno[2,3-b]pyridines and Their Related Heterocycles
AbstractHere, we described a facile method for synthesis of novel 1-piperidinyl and 1-piperazinyl-3-thioxo-6,7-dihydro-5 H -cyclopenta[ c ]pyridine-4-car...
-
NRF2 modulation in TRAMP mice: an in vivo model of prostate cancer
BackgroundProstate cancer (PCa) is one of the most common cancers worldwide and oxidative stress is involved in its occurrence, development and...
-
Synthesis, Reactions, and Antimicrobial Activity of Novel Heterocyclic Compounds Containing Cyclopenta[d]thieno[2,3-b]pyridine Moiety and Related Fused Heterocycles
AbstractWe describe a simple method to synthesize novel 4-cyano-1-morpholin-4-yl-6,7-dihydro-5 H -cyclopenta[ c ]pyridine-3-thione by the reaction of...
-
Design, synthesis, and biological evaluation of 4-(1H-1,2,3-triazol-1-yl)benzamides as HSP90 inhibitors
AbstractHeat shock protein 90 (HSP90) is a promising anticancer drug target, which could be employed to construct HSP90 inhibitors-based drug...
-
Synergistic antibacterial effects of Ulva lactuca methanolic extract alone and in combination with different antibiotics on multidrug-resistant Klebsiella pneumoniae isolate
Various antibiotics are available, including gentamicin, chloramphenicol, ampicillin, amoxicillin, and streptomycin, but they have some restrictions....
-
The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer
Apoptosis has long been recognized as a mechanism that kills the cancer cells by cytotoxic drugs. In recent years, studies have proved that...
-
Novel Synthesis, Reactions, and Biological Study of New Morpholino-Thieno[2,3-c][2,7]Naphthyridines as Anti-Cancer and Anti-Microbial Agents
AbstractThe biological uses of 2,7-naphthyridines have sparked great attention in recent years. For this reason, we synthesized a series of novel...
-
Identification of Potential Carbonic Anhydrase Inhibitors for Glaucoma Treatment Through an In-Silico Approach
Glaucoma is a neurodegenerative disease and second leading cause of blindness in western world. The disease is characterized by an elevated...
-
Biosystematic studies of some Egyptian species of Cestrum (Solanaceae)
Cestrum is the second largest genus of family Solanaceae, after Solanum, distributed in warm to subtropical regions. Species of genus Cestrum are one...
-
Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities
Controlling the activation of the NLRP3 inflammasome by post-translational modifications (PTMs) of critical protein subunits has emerged as a key...
-
Drug Design Methods to Regulate Protein–Protein Interactions
Inhibiting anomalous protein–protein interactions has led to the discovery of drugs (small molecules, precisely) that can inhibit such interactions...
-
GSK3β is a key regulator of the ROS-dependent necrotic death induced by the quinone DMNQ
Signaling pathways controlling necrosis are still mysterious and debated. We applied a shRNA-based viability screen to identify critical elements of...
-
The role of pyroptosis in cancer: pro-cancer or pro-“host”?
Programmed cell death (PCD) refers to the way in which cells die depending on specific genes encoding signals or activities. Apoptosis, autophagy,...
-
Synthesis of sulfur-containing heterocycles via ring enlargement
The current review deals with the use of ring expansion reactions for the synthesis of sulfur-containing heterocycles. Ring enlargement offers by far...
-
A novel four- and pseudo-five-component reaction: unexpected efficient one-pot synthesis of 4H-thiopyran derivatives
A facile and convenient novel method is reported for the synthesis of substituted 4 H -thiopyrans by reacting aldehydes, malononitrile, carbon...
-
Effects on varietal aromas during wine making: a review of the impact of varietal aromas on the flavor of wine
Although there are many chemical compounds present in wines, only a few of these compounds contribute to the sensory perception of wine flavor. This...
-
Development of a new air-stable structure-simplified nafuredin-γ analog as a potent and selective nematode complex I inhibitor
Nafuredin-γ, obtained from natural nafuredin, has demonstrated a potent and selective inhibitory activity against nematode complex I. However,...
-
-
