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1. Development and structure–activity relationships of tanshinones as selective 11β-hydroxysteroid dehydrogenase 1 inhibitors

   11 β -Hydroxysteroid dehydrogenase 1 (11 β -HSD1) represents a promising drug target for metabolic syndrome, including obesity and type 2 diabetes. Our...

   Xu Deng, Su-Ling Huang, ... Qin-Shi Zhao in Natural Products and Bioprospecting

   Article Open access 22 September 2022
   

2. Inhibition of 11β-hydroxysteroid dehydrogenase 1 relieves fibrosis through depolarizing of hepatic stellate cell in NASH

   11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) is a key enzyme that catalyzes the intracellular conversion of cortisone to physiologically active...

   Su-Yeon Lee, Sanghwa Kim, ... Haeng Ran Seo in Cell Death & Disease

   Article Open access 29 November 2022
   

3. Effects of terminal modification on the catalytic efficiency and thermostability of Brucella melitensis 7α-hydroxysteroid dehydrogenase

   Brucella melitensis 7α-hydroxysteroid dehydrogenase ( Bm 7α-HSDH) catalyzes the oxidation of chenodeoxycholic acid to 7-oxolithocholic acid. In this...

   Zhiyong Liu, Rongzhen Zhang, ... Yan Xu in Systems Microbiology and Biomanufacturing

   Article 23 August 2022
   

4. Single-Stage Bioconversion of Phytosterol into Testosterone by Recombinant Strains of Mycolicibacterium neoaurum

   Abstract

   A plasmid containing the genes encoding a fungal 17β-hydroxysteroid dehydrogenase, which ca-talyzes the reduction of 17-oxo group, and a...

   D. N. Tekucheva, M. V. Karpov, ... M. V. Donova in Microbiology

   Article 02 April 2024
   

5. Engineering of a borneol dehydrogenase from P. putida for the enzymatic resolution of camphor

   Abstract

   Several thousand different terpenoid structures are known so far, and many of them are interesting for applications as pharmaceuticals,...

   Michael Hofer, Julia Diener, ... Volker Sieber in Applied Microbiology and Biotechnology

   Article Open access 12 April 2021
   

6. Enhancing the biotransformation efficiency of human CYP17A1 in Pichia pastoris by co-expressing CPR and glucose-6-phosphate dehydrogenase simultaneously

   Steroids are a widely used class of drugs, and their hydroxylation modification has important pharmacological significance. Cytochrome P450 is the...

   Kexin Chen, Chao Liu, ... Zhiming Rao in Systems Microbiology and Biomanufacturing

   Article 09 November 2021
   

7. Expression of Synthetic cyp102A1-LG23 Gene and Functional Analysis of Recombinant Cytochrome P450 BM3-LG23 in the Actinobacterium Mycolicibacterium smegmatis

   Abstract

   Cytochrome CYP102A1 (P450 BM3) of Priestia megaterium (bas. Bacillus megaterium ) has several unique functional features and thus provides an...

   Veronika Y. Poshekhontseva, Nikolai I. Strizhov, ... Marina V. Donova in Biochemistry (Moscow)

   Article 22 September 2023
   

8. Integrated transcriptome and SNP analysis reveals sex-related genetic insights in the black-spotted frog (Pelophylax nigromaculatus)

   Pelop hyla x n igromaculatus is an important aquaculture economic animal in China, with an annual output of more than 80,000 tons in recent years. P....

   **ngyue Zhang, Gang Wan, ... Yazhou Hu in Aquaculture International

   Article 17 April 2024
   

9. Progress of 3-ketosteroid Δ¹-dehydrogenases for steroid production

   3-ketosteroid Δ ¹ -dehydrogenases (Δ ¹ -KstDs) are FAD-dependent and substrate-inducing enzymes, which catalyze the introduction of double bonds between...

   Bo Zhang, Deng-Feng Zhou, ... Yu-Guo Zheng in Systems Microbiology and Biomanufacturing

   Article 20 June 2023
   

10. Phytosterol conversion into C9 non-hydroxylated derivatives through gene regulation in Mycobacterium fortuitum

    Abstract

    Androst-4-ene-3,17-dione (AD) and 22-hydroxy-23,24-bisnorchol-4-ene-3-one (4-HBC) are important drug intermediates that can be biosynthesized...

    **angcen Liu, Beiru He, ... Baoguo Zhang in Applied Microbiology and Biotechnology

    Article 13 October 2023
    

11. Genome-wide identification and functional characterization of borneol dehydrogenases in Wurfbainia villosa

    Main conclusion

    Genome-wide screening of short-chain dehydrogenases/reductases (SDR) family reveals functional diversification of borneol...

    **ao**g Lin, Linxuan Huang, ... **fen Yang in Planta

    Article 22 August 2023
    

12. Molecular characterization and expression analysis of saxitoxin biosynthesis gene sxtU from toxigenic dinoflagellate Alexandrium pacificum

    The marine dinoflagellate Alexandrium is known to produce saxitoxins (STXs), causing paralytic shellfish poisoning (PSP). STX biosynthesis is...

    Quynh Thi Nhu Bui, Jang-Seu Ki in Journal of Applied Phycology

    Article 16 February 2023
    

13. Whole-genome analyses and metabolic modification of Mycobacterium sp. LY-1 to enhance yield of 9α-OH-AD

    With the increasing application of steroid drugs as therapeutics, the demand for steroid drugs is increasing. In recent years, biological synthesis...

    W. Liu, H. Li, ... Z. H. Xu in Systems Microbiology and Biomanufacturing

    Article 11 May 2022
    

14. DNA Methylation Profiling of Ovarian Tissue of Climbing Perch (Anabas testudienus) in Response to Monocrotophos Exposure

    Epigenetic modifications like DNA methylation can alter an organism’s phenotype without changing its DNA sequence. Exposure to environmental...

    Kiran D. Rasal, Sujata Mohapatra, ... Jitendra Kumar Sundaray in Marine Biotechnology

    Article 23 October 2023
    

15. Ovarian ERβ cistrome and transcriptome reveal chromatin interaction with LRH-1

    Background

    Estrogen receptor beta (ERβ, Esr2) plays a pivotal role in folliculogenesis and ovulation, yet its exact mechanism of action is mainly...

    Madeleine Birgersson, Rajitha Indukuri, ... Cecilia Williams in BMC Biology

    Article Open access 29 November 2023
    

16. In Silico Analysis of the Phylogenetic and Physiological Characteristics of Sphingobium indicum B90A: A Hexachlorocyclohexane-Degrading Bacterium

    The study focuses on the in silico genomic characterization of Sphingobium indicum B90A, revealing a wealth of genes involved in stress response,...

    Jasvinder Kaur, Helianthous Verma, ... Rup Lal in Current Microbiology

    Article 21 June 2024
    

17. Current Trends and Perspectives in Microbial Bioconversions of Steroids

    The microbiological transformation of sterols is currently the technological basis for the industrial production of valuable steroid precursors, the...

    Marina V. Donova in Microbial Steroids

    Protocol 2023
    

18. Cascade Biotransformation of Phytosterol to Testosterone by Mycolicibacterium neoaurum VKM Ас-1815D and Nocardioides simplex VKM Ас-2033D Strains

    Abstract —

    New methods for testosterone production from phytosterol were developed based on its cascade two-stage transformation by actinobacteria Mycol...

    D. N. Tekucheva, V. V. Fokina, ... M. V. Donova in Microbiology

    Article 03 June 2022
    

19. Proteome profiling, biochemical and histological analysis of diclofenac-induced liver toxicity in Yersinia enterocolitica and Lactobacillus fermentum fed rat model: a comparative analysis

    Diclofenac is a hepatotoxic non-steroidal anti-inflammatory drug (NSAID) that affects liver histology and its protein expression levels. Here, we...

    Shruti Ahlawat, Hari Mohan, Krishna Kant Sharma in Biotechnology Letters

    Article 10 July 2024
    

20. Multi-genome comparisons reveal gain-and-loss evolution of anti-Mullerian hormone receptor type 2 as a candidate master sex-determining gene in Percidae

    Background

    The Percidae family comprises many fish species of major importance for aquaculture and fisheries. Based on three new chromosome-scale...

    Heiner Kuhl, Peter T. Euclide, ... Yann Guiguen in BMC Biology

    Article Open access 26 June 2024