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Synthesis of Indole-1,3,4-Oxadiazole Based Sulfonyl 1,2,3-Triazoles as Potent Anticancer and EGFR Inhibitors
AbstractHerein, we synthesized some new indole-1,3,4-oxadiazole based sulfonyl 1,2,3-triazoles via a click chemistry approach and then characterized...
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Synthesis of Some New Indole-1,3,4-Oxadiazole Hybrids as Tubulin Polymerization Inhibitors
AbstractWe have synthesized some new molecular hybrids containing indole and 1,3,4-oxadiazole rings from the commercially available ethyl 1 H -indole-2...
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Synthesis and Characterization of New 1,3,4-Oxadiazole Ring on Creatinine Derivatives Using Iodine and Study Their Anticancer Effect
AbstractUsing the iodine method, new 1,3,4-oxadiazole compounds ( IIa–b ) synthesized from creatinine can be produced in good yield. FT-IR and 1 H NMR...
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Synthesis and Biological Evaluation of Chromene-1,3,4-Oxadiazole based 1,2,3-Triazoles: EGFR-targeting Anticancer Agents
AbstractIn search of the better anticancer agents, a series of chromene-1,3,4-oxadiazole containing 1,2,3-triazole derivatives were synthesized using...
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Towards new bioactive fluorine-containing 1,3,4-oxadiazole-amide derivatives: synthesis, antibacterial activity, molecular docking and molecular dynamics simulation study
Through the approach of molecular hybridization, this study rationally designed and synthesized new trifluoromethyl-1,3,4-oxadiazole amide...
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Rational design, synthesis, and antimicrobial evaluation of novel 1,2,4-trizaole-substituted 1,3,4-oxadiazole derivatives with a dual thioether moiety
In this paper, a series of novel 1,2,4-trizaole-substituted 1,3,4-oxadiazole derivatives with a dual thioether moiety were constructed. The synthetic...
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Synthesis, biological activities and mechanism studies of 1,3,4-oxadiazole analogues of petiolide A as anticancer agents
In order to develop new natural product-based anticancer agents, a series of 1,3,4-oxadiazole analogues based on petiolide A were prepared and...
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Design and Synthesis of Some New Quinoxaline Containing 1,3,4-Oxadiazole Hybrids and Evaluation of Their Anti-Cancer Activity
AbstractHerein, we synthesized some new quinoxaline-1,3,4-oxadiazole hybrids ( Va – n ) and evaluated for their in vitro anticancer potency towards A549...
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Synthesis and Characterization of Substituted 5-(2-Chloroquinolin-3-yl)-1,3,4-oxadiazole-2-amines: Computational, In Silico ADME, Molecular Docking, and Biological Activities
AbstractA series of 5-(2-chloroquinolin-3-yl)-1,3,4-oxadiazole-2-amine ( IIIa–IIIj ) with different biological activities were designed and...
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Synthesis, carbonic anhydrase inhibition, anticancer activity, and molecular docking studies of 1,3,4-oxadiazole derivatives
In this work, we have synthesized various organic compounds possessing 1,3,4-oxadiazole as a core structure and the structure of the newly...
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Synthesis and Study the Biological Activity of Some New Pyrazole Compounds Containing 1,3,4-Oxadiazole Unite Through Vilsmeier–Haack Reaction
AbstractObjective: A new series of pyrazole-3-carbaldehyde derivatives from new hydrazones by using the Vilsmeier–Haack reaction were synthesized....
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Novel heterocyclic 1,3,4-oxadiazole derivatives of fluoroquinolones as a potent antibacterial agent: Synthesis and computational molecular modeling
Design and synthesis of novel series of 1,3,4-oxadiazoles containing FQs derivatives and screened their antibacterial, antimycobacterial properties....
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Synthesis, Anticancer Activity and Computational Docking Techniques of Some Novel Derivatives Based on Indole Bearing Oxadiazole–Triazole Moieties
AbstractIn this study, a new series of 1,4-disubstituted-1,2,3-triazole and 2,5-disubstituted oxadiazole tethered indole compounds were synthesized...
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Synthesis and Biological Evaluation of Theophylline Methyl 1,3,4-Oxadiazole as Anticancer Agents
AbstractA series of theophylline methyl 1,3,4-oxadiazole small molecules were obtained via cyclization of theophylline-7-acetohydrazide with...
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Microwave-Assisted Synthesis and Molecular Docking Studies of Fluorinated 1,3,4-Oxadiazole Derivatives as Antimicrobial Agent
AbstractA series of phenyl-5-(2,3,5,6-tetrafluoro-phenyl)-[1,3,4]-oxadiazole were prepared from 2,3,5,6-tetrafluoro-benzoic acid hydrazide by...
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Ultrasound-assisted, low-solvent and acid/base-free synthesis of 5-substituted 1,3,4-oxadiazole-2-thiols as potent antimicrobial and antioxidant agents
AbstractOne of the goals of green chemistry is to use environmentally friendly solvents or remove and reduce the volume of harmful spent solvents. In...
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Biological activity of oxadiazole and thiadiazole derivatives
AbstractThe 5-membered oxadiazole and thiadiazole scaffolds are the most privileged and well-known heterocycles, being a common and essential feature...
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In Silico Docking Studies, Synthesis, Characterization, and Antimicrobial Antimycobacterial Activity of Coumarinyl Oxadiazoles from Fatty Acids
AbstractThis present study deals with the design and evaluation of novel coumarinyl oxadiazoles substituted fatty acids derivatives using synthetic...
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Diversity-oriented synthesis and antifungal activities of novel pimprinine derivative bearing a 1,3,4-oxadiazole-5-thioether moiety
AbstractBased on the strategy of diversity-oriented synthesis and the structures of natural product pimprinine and streptochlorin, two series of...
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Oxadiazol-based mTOR inhibitors with potent antiproliferative activities: synthetic and computational modeling
Series of N -aryl-1,3,4-oxadiazole-2-amines and 3-aryl-1,2,4-oxadiazole-5-carboxamides derivatives were synthesized as novel chemotherapeutic agents....
