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Molecular evolution of transcription factors AF4/FMR2 family member (AFF) gene family and the role of lamprey AFF3 in cell proliferation
AF4/FMR2 family member (AFF) proteins are a group of transcriptional regulators that can regulate gene transcription and play an important role in...
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Family-Free Genome Comparison
The comparison of large-scale genome structures across distinct species offers valuable insights into the species’ phylogeny, genome organization,...
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FOXO family isoforms
FOXO family of proteins are transcription factors involved in many physiological and pathological processes including cellular homeostasis, stem cell...
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The Great Family of Life
Where does my family end? At my parents and siblings? At my grandparents, aunts, uncles and cousins? At my in-laws? At my second cousins? At my...
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Deep generative design of RNA family sequences
RNA engineering has immense potential to drive innovation in biotechnology and medicine. Despite its importance, a versatile platform for the...
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Tspan protein family: focusing on the occurrence, progression, and treatment of cancer
The Tetraspanins (Tspan) protein family, also known as the tetraspanin family, contains 33 family members that interact with other protein molecules...
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Mechanisms of BCL-2 family proteins in mitochondrial apoptosis
The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as either promoters or inhibitors of cell death. The...
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Context-dependent TGFβ family signalling in cell fate regulation
The transforming growth factor-β (TGFβ) family are a large group of evolutionarily conserved cytokines whose signalling modulates cell fate...
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Automatic annotation of the bHLH gene family in plants
BackgroundThe bHLH transcription factor family is named after the basic helix-loop-helix (bHLH) domain that is a characteristic element of their...
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The role of CXCL family members in different diseases
Chemokines are a large family mediating a lot of biological behaviors including chemotaxis, tumor growth, angiogenesis and so on. As one member of...
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The Theory of Gene Family Histories
Most genes are part of larger families of evolutionary-related genes. The history of gene families typically involves duplications and losses of...
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A revised nomenclature for the lemur family of protein kinases
The lemur family of protein kinases has gained much interest in recent years as they are involved in a variety of cellular processes including...
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Rho Family GTPases and their Modulators
The Rho family GTPases play an important role in mediating signal transduction in multiple fundamental cellular processes. Most of the Rho family...
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Sequence-structural features and evolution of the α-amylase family GH119 revealed by the in silico analysis of its relatedness to the family GH57
In the sequence-based classification of glycoside hydrolases (GHs) of the CAZy database, the family GH119 represents one of the four α-amylase GH...
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Genome-wide identification and analysis of the cotton ALDH gene family
BackgroundAldehyde dehydrogenases (ALDHs) are a family of enzymes that catalyze the oxidation of aldehyde molecules into the corresponding carboxylic...
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Identification and expression analysis of XIP gene family members in rice
Xylanase inhibitor proteins (XIP) are widely distributed in the plant kingdom, and also exist in rice. However, a systematic bioinformatics analysis...
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Evolutionary origin and gradual accumulation with plant evolution of the LACS family
BackgroundLACS (long-chain acyl-CoA synthetase) genes are widespread in organisms and have multiple functions in plants, especially in lipid...
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Identification of pan-kinase-family inhibitors using graph convolutional networks to reveal family-sensitive pre-moieties
BackgroundHuman protein kinases, the key players in phosphoryl signal transduction, have been actively investigated as drug targets for complex...
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Characterization of Multi-Domain Proteins in the ArsR/SmtB Family of Transcriptional Regulators
AbstractStudies centered on single-domain proteins revealed several fundamental characteristics about how they work, but the multimeric proteins are...
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Role of the Ror family receptors in Wnt5a signaling
Ror-family receptors, Ror1 and Ror2, are type I transmembrane proteins that possess an extracellular cysteine-rich domain, which is conserved...
