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Alternative Splicing Methods and Protocols
This detailed volume collects commonly used and cutting-edge methods to analyze alternative splicing, a key step in gene regulation. After an...
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Determination of Differential Alternative Splicing Under Stress Conditions
Alternative splicing (AS) is an important mechanism contributing to stress-induced regulation of gene expression and proteome diversity. Massive...
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The physiology of alternative splicing
Alternative splicing is a substantial contributor to the high complexity of transcriptomes of multicellular eukaryotes. In this Review, we discuss...
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Combining genetic constraint with predictions of alternative splicing to prioritize deleterious splicing in rare disease studies
BackgroundDespite numerous molecular and computational advances, roughly half of patients with a rare disease remain undiagnosed after exome or...
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rMATS-turbo: an efficient and flexible computational tool for alternative splicing analysis of large-scale RNA-seq data
Pre-mRNA alternative splicing is a prevalent mechanism for diversifying eukaryotic transcriptomes and proteomes. Regulated alternative splicing plays...
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ASAPA: a bioinformatic pipeline based on Iso-Seq that identifies the links among alternative splicing, alternative transcription initiation and alternative polyadenylation
Background: Although the events associated with alternative splicing (AS), alternative polyadenylation (APA) and alternative transcription initiation...
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Nanopore long-read RNA sequencing reveals functional alternative splicing variants in human vascular smooth muscle cells
Vascular smooth muscle cells (VSMCs) are the major contributor to vascular repair and remodeling, which showed high level of phenotypic plasticity....
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Modulatory role of RNA helicases in MBNL-dependent alternative splicing regulation
Muscleblind-like splicing regulators (MBNLs) activate or repress the inclusion of alternative splicing (AS) events, enabling the developmental...
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Splicing complexity as a pivotal feature of alternative exons in mammalian species
BackgroundAs a significant process of post-transcriptional gene expression regulation in eukaryotic cells, alternative splicing (AS) of exons greatly...
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ESRP1-driven alternative splicing of CLSTN1 inhibits the metastasis of gastric cancer
Tumor metastasis severely limits the prognosis of gastric cancer patients. RNA-binding proteins (RBPs) are crucial in tumor metastasis, yet there is...
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Resurrecting the alternative splicing landscape of archaic hominins using machine learning
Alternative splicing contributes to adaptation and divergence in many species. However, it has not been possible to directly compare splicing between...
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eEF1A1 regulates the expression and alternative splicing of genes associated with Parkinson’s disease in U251 cells
BackgroundEukaryotic elongation factor 1A1 (eEF1A1) is an RNA-binding protein that is associated with PARK2 activity in cells, suggesting a possible...
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Talaromyces marneffei suppresses macrophage inflammation by regulating host alternative splicing
Talaromyces marneffei ( T. marneffei ) immune escape is essential in the pathogenesis of talaromycosis. It is currently known that T. marneffei ...
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Alternative Splicing of Pre-messenger RNA
Alternative splicing is a critical component of gene expression. Virtually all multiexon genes undergo alternative splicing. By combining the...
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Manual correction of genome annotation improved alternative splicing identification of Artemisia annua
Gene annotation is essential for genome-based studies. However, algorithm-based genome annotation is difficult to fully and correctly reveal genomic...
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The function of alternative splicing in the proteome: rewiring protein interactomes to put old functions into new contexts
Alternative splicing affects more than 95% of multi-exon genes in the human genome. These changes affect the proteome in a myriad of ways. Here, we...
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Transcriptome reprogramming through alternative splicing triggered by apigenin drives cell death in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is characterized by its aggressiveness and resistance to cancer-specific transcriptome alterations. Alternative...
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USP39 promotes hepatocellular carcinogenesis through regulating alternative splicing in cooperation with SRSF6/HNRNPC
Abnormal alternative splicing (AS) caused by alterations in spliceosomal factors is implicated in cancers. Standard models posit that splice site...
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Alternative Splicing in Human Biology and Disease
Alternative pre-mRNA splicing allows for the production of multiple mRNAs from an individual gene, which not only expands the protein-coding...
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Comprehensive deciphering the alternative splicing patterns involved in leaf morphogenesis of Liriodendron chinense
Alternative splicing (AS), a pivotal post-transcriptional regulatory mechanism, profoundly amplifies diversity and complexity of transcriptome and...
