Search
Search Results
-
A tissue specific-infection mouse model of SARS-CoV-2
Animal models play crucial roles in the rapid development of vaccines/drugs for the prevention and therapy of COVID-19, but current models have some...
-
Effect of the Coat Protein N-Terminal Domain Structure on the Structure and Physicochemical Properties of Virions of Potato Virus X and Alternanthera Mosaic Virus
AbstractThe amino acid sequences of the coat proteins (CPs) of the potexviruses potato virus X (PVX) and alternanthera mosaic virus (AltMV) share...
-
Changes in the Structure of Potato Virus A Virions after Limited in situ Proteolysis According to Tritium Labeling Data and Computer Simulation
AbstractCoat proteins (CP) of the potato virus A virions (PVA) contain partially disordered N-terminal domains, which are necessary for performing...
-
Role of Mod(mdg4)-67.2 Protein in Interactions between Su(Hw)-Dependent Complexes and Their Recruitment to Chromatin
AbstractSu(Hw) belongs to the class of proteins that organize chromosome architecture, determine promoter activity, and participate in formation of...
-
Cryo-EM structure of the Rev1–Polζ holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis
Rev1–Polζ-dependent translesion synthesis (TLS) of DNA is crucial for maintaining genome integrity. To elucidate the mechanism by which the two...
-
Atomistic ensemble of active SHP2 phosphatase
SHP2 phosphatase plays an important role in regulating several intracellular signaling pathways. Pathogenic mutations of SHP2 cause developmental...
-
Pcal_2031, a RecA/Rad51 homologue from Pyrobaculum calidifontis, complements the ultraviolet light sensitivity of Escherichia coli
RecA/Rad51 family proteins assist in DNA repair. Current study was targeted on molecular cloning, expression in Escherichia coli and characterization...
-
Lysyl oxidase-like 2 processing by factor Xa modulates its activity and substrate preference
Lysyl oxidase-like 2 (LOXL2) has been identified as an essential mediator of extracellular matrix (ECM) remodeling in several disease processes...
-
The Possibility of Pore Formation in Lipid Membranes by Several Molecules of Amphipathic Peptides
AbstractAntimicrobial activity of some amphipathic peptides is associated with the formation of through pores in bacterial membranes. Antimicrobial...
-
Rapid biosensor development using plant hormone receptors as reprogrammable scaffolds
A general method to generate biosensors for user-defined molecules could provide detection tools for a wide range of biological applications. Here,...
-
Optimal Control
Wir beginnen mit einer allgemein gehaltenen Beschreibung des Problems der optimalen Steuerung. Auch im deutschen Sprachraum hat sich dafür der...
-
A novel approach to quantifying individual's biological aging using Korea’s national health screening program toward precision public health
Accurate prediction of biological age can inform public health measures to extend healthy lifespans and reduce chronic conditions. Multiple...
-
STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2
Evasion of antitumour immunity is a hallmark of cancer. STING, a putative innate immune signalling adaptor, has a pivotal role in mounting antitumour...
-
Blood-Retinal Barrier Development and Potential for Regeneration in Blinding Eye Disease
The blood-retinal barrier (BRB) creates the defined retinal environment necessary for neuronal signaling and vision. The well-developed tight...
-
SARS-CoV-2 ORF6 protein targets TRIM25 for proteasomal degradation to diminish K63-linked RIG-I ubiquitination and type-I interferon induction
Evasion and antagonism of host cellular immunity upon SARS-CoV-2 infection provide replication advantage to the virus and contribute to COVID-19...
-
Casein kinase 2 phosphorylates and induces the SALL2 tumor suppressor degradation in colon cancer cells
Spalt-like proteins are Zinc finger transcription factors from Caenorhabditis elegans to vertebrates, with critical roles in development. In...
-
Global investigation of lake habitat coupling by fishes
Habitat coupling, where consumers acquire resources from different habitats, plays an important role in ecosystem functioning. In this study, we...
-
MRTF-A gain-of-function in mice impairs homeostatic renewal of the intestinal epithelium
The actin-regulated transcription factor MRTF-A represents a central relay in mechanotransduction and controls a subset of SRF-dependent target...
-
Parkin-mediated ubiquitination inhibits BAK apoptotic activity by blocking its canonical hydrophobic groove
BAK permeabilizes the mitochondrial outer membrane, causing apoptosis. This apoptotic activity of BAK is stimulated by binding prodeath activators...
-
An inhibitory effect on the nuclear accumulation of phospho-STAT1 by its unphosphorylated form
BackgroundUnphosphorylated signal transducer and activator of transcription 1 (U-STAT1) has been reported to elicit a distinct gene expression...
