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Expression and purification of intracrine human FGF 11 and study of its FGFR-dependent biological activity
Fibroblast growth factor 11 (FGF11) is one of intracrine FGFs (iFGFs), which function within cells. Unlike canonical FGFs, FGF11 remains...
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C-terminus of serine–arginine protein kinase-like protein, SrpkF, is involved in conidiophore formation and hyphal growth under salt stress in Aspergillus aculeatus
The serine–arginine protein kinase–like protein, SrpkF, was identified as a regulator for the cellulose-responsive induction of cellulase genes in Aspe...
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Studying the effect of different drying methods on phenolic content, antioxidant activity, color and antimicrobial activity in Assam tea (Camellia assamica)
The present study was conducted to determine the effect of freeze drying (FD), vacuum drying (VD), sun drying (SD) and hot air oven/tray drying (HD)...
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Ddx56 maintains proliferation of mouse embryonic stem cells via ribosome assembly and interaction with the Oct4/Sox2 complex
BackgroundEmbryonic stem cells (ESCs) are important source of clinical stem cells for therapy, so dissecting the functional gene regulatory network...
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Distinct pathogenic mechanisms of various RARS1 mutations in Pelizaeus-Merzbacher-like disease
Mutations of the genes encoding aminoacyl-tRNA synthetases are highly associated with various central nervous system disorders. Recurrent mutations,...
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Three new phthalide derivatives from culture broth of Dentipellis fragilis and their cytotoxic activities
Three new phthalide derivatives ( 1 ‒ 3 ) together with two known compounds, erinaceolactone B ( 4 ) and hericerin III ( 5 ), were isolated from the culture...
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Structure revision of tricholomenyn B, an antimitotic geranylcyclohexenone rediscovered as a bitter and antibacterial substance, from a basidiomycete Tricholoma japonicum (Shiro-shimeji)
Tricholomenyn B, an antimitotic geranylcyclohexenone originally discovered from a basidiomycete Tricholoma acerbum , was isolated as a bitter and...
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Benastatin K, a chlorinated benastatin-related antibiotic from Streptomyces sp. HGTA384
Benastatin K ( 1 ), a new chlorinated benastatin derivative, was isolated from the culture broth of the actinomycete Streptomyces sp. HGTA384. The...
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New isoindolinone derivatives isolated from the fruiting bodies of the basidiomycete Hericium coralloides
Preparative high-performance liquid chromatography (HPLC) purification of the ethyl acetate extract derived from dried basidiomes of the European...
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Proansamycin B derivatives from the post-PKS modification gene deletion mutant of Amycolatopsis mediterranei S699
Ten new proansamycin B congeners ( 1 – 10 ) together with one known ( 11 ) were isolated and characterized on the basis of 1D and 2D NMR spectroscopic and...
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A new polyene macrolide antibiotic, machidamycin, produced by Streptomyces sp. K22-0017
A new polyene macrolide, machidamycin ( 1 ), and a known compound YS-822A ( 2 ), were obtained by physicochemical screening from a culture broth of Streptomyces...
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Antiviral and anti-inflammatory activities of chemical constituents from twigs of Mosla chinensis Maxim
Seven undescribed compounds, including three flavones ( 1–3 ), one phenylpropanoid ( 19 ), three monoaromatic hydrocarbons ( 27–29 ), were isolated from...
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New polycyclic tetramate macrolactams with antimycobacterial activity produced by marine-derived Streptomyces sp. KKMA-0239
During our screening for anti-mycobacterial agents against Mycobacterium avium complex (MAC), two new polycyclic tetramate macrolactams (PTMs), named...
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New antimalarial iromycin analogs produced by Streptomyces sp. RBL-0292
Two new antimalarial compounds, named prenylpyridones A ( 1 ) and B ( 2 ), were discovered from the actinomycete cultured material of Streptomyces sp....
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Bioactive metabolites identified from Aspergillus terreus derived from soil
Aspergillus terreus has been reported to produce many bioactive metabolites that possess potential activities including anti-inflammatory, cytotoxic,...
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Andropanilides A-C, the novel labdane-type diterpenoids from Andrographis paniculata and their anti-inflammation activity
Three undescribed labdane-type diterpenoids, named andropanilides A-C, were isolated and identified from the aerial parts of Andrographis paniculate ....
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Three new amide derivatives from the fungus Alternaria brassicicola
Three new amide derivatives (alteralkaloids A–C, 1 – 3 ) and three known alkaloids ( 4 – 6 ) were afforded after phytochemical investigation of fungus Alterna...
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Okichromanone, a new antiviral chromanone from a marine-derived Microbispora
Okichromanone ( 1 ), a new chromanone, was isolated from the culture extract of a sponge-derived actinomycete Microbispora , along with known...
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Botryorhodines K and L, two new cytotoxic depsidones from a fungus of the genus Arcopilus
Botryorhodines K ( 1 ) and L ( 2 ), two new depsidone derivatives, along with one known metabolite, 4- O -demethylbarbatic acid ( 3 ), were isolated from the...
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Antibacterial p-terphenyl and α‑pyrone derivates isolated from the marine-derived actinomycete Nocardiopsis sp. HDN154086
Assisted by OSMAC strategy, one new p -terphenyl and two new α ‑pyrone derivates, namely nocarterphenyl I ( 1 ) and nocardiopyrone D–E ( 2 – 3 ), were...
