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New Zwitter-Ionic Oligonucleotides: Preparation and Complementary Binding
AbstractNew zwitter-ionic oligonucleotide derivatives containing 1,2,3,4-tetrahydroisoquinoline-7-sulfonyl phosphoramidate group are described....
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Gene Isolation Methods: Beginner’s Guide
As the structure of DNA is fundamentally the same in all living organisms, theoretically any segment of DNA from any organism can be introduced in...
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Study of the Staudinger Reaction and Reveal of Key Factors Affecting the Efficacy of Automatic Synthesis of Phosphoryl Guanidinic Oligonucleotide Analogs
AbstractIn this work, we introduce a novel nuanced analysis of the chemical transformations occurs during the automatic synthesis of phosphoryl...
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New Oligodeoxynucleotide Derivatives Containing N-(Sulfonyl)-Phosphoramide Groups
Abstract —New oligodeoxynucleotide derivatives containing N -( o -nitrobenzenesulfonyl)-phosphoramide (nosyl phosphoramide), N -(1-butanesulfonyl)-phospho...
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Triazinylamidophosphate Oligonucleotides: Synthesis and Study of Their Interaction with Cells and DNA-Binding Proteins
AbstractIn this work, representatives of the class of triazinylamidophosphate oligonucleotide derivatives were obtained for the first time. A scheme...
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Glycoconjugate Vaccines for Prevention of Haemophilus influenzae Type b Diseases
AbstractThis review summarizes the experience in laboratory- and industrial-scale syntheses of glycoconjugate vaccines used for prevention of...
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New oligodeoxyribonucleotide derivatives bearing internucleotide N-tosyl phosphoramidate groups: Synthesis and complementary binding to DNA and RNA
N -Sulfonyl phosphoramidate derivatives of oligodeoxyribonucleotides containing N -tosyl phosphoramidate groups are first reported. The synthesis is...
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Synthesis of β-Diketone DNA Derivatives for Affinity Modification of Proteins
AbstractDiketone DNA derivatives have been proposed to modify the guanidine group of Arg in proteins. The β-diketo group at the C2' atom of the sugar...
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Focus on O-phosphohydroxylysine, O-phosphohydroxyproline, N 1-phosphotryptophan and S-phosphocysteine
The synthesis and chemistry of the lesser-known phosphoamino acids, O -phosphohydroxylysine, O -phosphohydroxyproline, N 1 -phosphotryptophan and S -phosp...
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Impact of chemical modifications in the structure of isRNA on its antiproliferative and immunostimulatory properties
Short double-stranded RNAs, depending on their structure, sequence, and the method of delivery to cells, can activate the system of innate and...
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A review of syntheses of 1,5-disubstituted tetrazole derivatives
This report provides a brief overview of the various representative literature procedures for the synthesis of 1,5-disubstituted tetrazoles...
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Synthesis of Site-Specifically Modified Long-mer RNAs
Site-specific functionalization of RNA and DNA molecules has become a major task in nucleic acid chemistry. Synthetic RNAs are required for a large...
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Protective groups in the chemical synthesis of oligoribonucleotides
The methods of chemical oligoribonucleotide synthesis and the protective groups used are reviewed. The latest data on the protection of 2′-OH...
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Reflections on biocatalysis involving phosphorus
Early studies on chemical synthesis of biological molecules can be seen to progress to preparation and biological evaluation of phosphonates as...
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Synthesis of a Glycomimetic Oligonucleotide Conjugate by 1,3-Dipolar Cycloaddition
A glycomimetic oligonucleotide conjugate bearing four galactose residues on a mannose core is synthesized using oligonucleotide solid-phase...
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Fluorescent Labeling and Its Effect on Hybridization of Oligodeoxyribonucleotides
Biophysical labeling involves selective modification of biological objects with various types of labels capable of providing information on their...
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Solid-Phase Synthesis of Modified Oligonucleotides
Synthetic oligonucleotides are ubiquitously found in most laboratories since solid-phase synthesis protocols have become highly optimized. These...
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Novel Cu(II)-quinoline carboxamide complexes: Structural characterization, cytotoxicity and reactivity towards 5′-GMP
Three new ligands, N-(8-quinolyl)pyridine-2-carboxamide (HL 1 ), N-(8-quinolyl)glycine-N′-Boc-carboxamide (HL 2 ),...
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Protein Engineering with Nonstandard Amino Acids
Site-directed mutagenesis has become an extremely powerful tool for the study of protein folding, protein-protein interactions, enzymatic catalysis,...
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Construction of Linker-Scanning Mutations by Oligonucleotide Ligation
The purpose of linker-scanning mutagenesis is to create a series of mutant molecules in which individual sections are sequentially replaced with the...