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Impairing hydrolase transport machinery prevents human melanoma metastasis
Metastases are the major cause of cancer-related death, yet, molecular weaknesses that could be exploited to prevent tumor cells spreading are poorly...
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Capturing acyl–enzyme intermediates with genetically encoded 2,3-diaminopropionic acid for hydrolase substrate identification
Catalytic mechanism-based, light-activated traps have recently been developed to identify the substrates of cysteine or serine hydrolases. These...
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Recent advances in enzymatic properties, preparation methods, and functions of glycoside hydrolase from Bifidobacterium: a review
Bifidobacterium is a major probiotic of intestinal gut flora and exerts many physiological activities, and it is widely applied in the fields of food...
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Improving ethanol tolerance of ethyl carbamate hydrolase by diphasic high pressure molecular dynamic simulations
Ethyl carbamate (EC) is mainly found in fermented foods and fermented alcoholic beverages, which could cause carcinogenic potential to humans....
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The Cholesterol-5,6-Epoxide Hydrolase: A Metabolic Checkpoint in Several Diseases
Cholesterol-5,6-epoxides (5,6-ECs) are oxysterols (OS) that have been linked to several pathologies including cancers and neurodegenerative diseases....
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Essential amino acid residues and catalytic mechanism of trans-epoxysuccinate hydrolase for production of meso-tartaric acid
ObjectivesThis study aimed to discuss the essential amino acid residues and catalytic mechanism of trans -epoxysuccinate hydrolase from Pseudomonas...
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The global distribution of the macrolide esterase EstX from the alpha/beta hydrolase superfamily
Macrolide antibiotics, pivotal in clinical therapeutics, are confronting resistance challenges mediated by enzymes like macrolide esterases, which...
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A new and promiscuous α/β hydrolase from Acinetobacter tandoii DSM 14970 T inactivates the mycotoxin ochratoxin A
AbstractThe presence of ochratoxin A (OTA) in food and feed represents a serious concern since it raises severe health implications. Bacterial...
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Visualization of a Cell Wall Hydrolase Inhibitor in Fusobacterium nucleatum by Immunofluorescence Microscopy
Innately present in tears, saliva and mucosal secretions, lysozyme provides a critical defensive strategy to the host by cleaving the...
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Potential of Y. lipolytica epoxide hydrolase for efficient production of enantiopure (R)-1,2-octanediol
The recombinant Yleh from a tropical marine yeast Yarrowia lipolytica NCIM 3589 exhibited a high epoxide hydrolase activity of 9.34 ± 1.80 µmol min -1 mg...
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Fatty acid amide hydrolase drives adult mammary gland development by promoting luminal cell differentiation
Mammary gland development occurs primarily in adulthood, undergoing extensive expansion during puberty followed by cycles of functional...
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Efficient biodegradation of sodium dodecyl sulfate (SDS) by the cyanobacterium Fischerella sp. lmga1 harbouring SdsA1 hydrolase
Sodium dodecyl sulfate (SDS) accumulation in nature impart detrimental effects on various lifeforms as it truncates cellular proteins. The present...
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Glycoside hydrolase processing of the Pel polysaccharide alters biofilm biomechanics and Pseudomonas aeruginosa virulence
Pel exopolysaccharide biosynthetic loci are phylogenetically widespread biofilm matrix determinants in bacteria. In Pseudomonas aeruginosa , Pel is...
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Identification of a novel glycoside hydrolase family 8 xylanase from Deinococcus geothermalis and its application at low temperatures
Xylanase is the most important hydrolase in the xylan hydrolase system, the main function of which is β-1,4-endo-xylanase, which randomly cleaves...
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Improved thermostability of maltooligosyl trehalose hydrolase by computer-aided rational design
Trehalose is a widely used and safe natural disaccharide. Maltooligosyl trehalose hydrolase(MTHase) is one of the key enzymes for trehalose...
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Substrate Inhibition of the Highly Efficient PET Hydrolase
AbstractPolyethylene terephthalate (PET) is one of the most abundant polyester materials used in daily life and it is also one of the culprits of...
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CRYPTOCHROME 1a-mediated blue light perception regulates tomato seed germination via changes in hormonal balance and endosperm-degrading hydrolase dynamics
Main conclusionBlue light exposure delays tomato seed germination by decreasing endosperm-degrading hydrolase activities, a process regulated by...
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Identification of enzymatic functions of osmo-regulated periplasmic glucan biosynthesis proteins from Escherichia coli reveals a novel glycoside hydrolase family
Most Gram-negative bacteria synthesize osmo-regulated periplasmic glucans (OPG) in the periplasm or extracellular space. Pathogenicity of many...
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Biofilms from the Kapova Cave Walls as a Source of Hydrolase Producers
AbstractThe studies of bacterial communities from extreme econiches are presently aimed mainly at analyzing the biodiversity of microorganisms using...
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S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) inhibits lung cancer tumorigenesis by regulating cell plasticity
BackgroundLung cancer is one of the most frequently diagnosed cancers characterized by high mortality, metastatic potential, and recurrence....
