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DUSP4 modulates RIG-I- and STING-mediated IRF3-type I IFN response
Detection of cytosolic nucleic acids by pattern recognition receptors, including STING and RIG-I, leads to the activation of multiple signalling...
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SARS-CoV-2 ORF6 protein targets TRIM25 for proteasomal degradation to diminish K63-linked RIG-I ubiquitination and type-I interferon induction
Evasion and antagonism of host cellular immunity upon SARS-CoV-2 infection provide replication advantage to the virus and contribute to COVID-19...
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“If I Were in Nature’s Place, I Would Do It Like This...” Life and Hypotheses of Alexey Olovnikov
AbstractIn this article, we commemorate the life and scientific journey of the brilliant gerontologist-theorist Alexey Olovnikov (1936-2022). In...
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Upregulation of MHC I Antigen Processing Machinery Gene Expression in Breast Cancer Cells by Trichostatin A
AbstractEpigenetic alterations associated with cancer have been shown to facilitate tumorigenesis and promote metastasis. In the study of cancer...
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VRK1 promotes DNA-induced type I interferon production
BackgroundType I interferons (IFNs) are an essential class of cytokines with antitumor, antiviral and immunoregulatory effects. However,...
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ArdA Protein Specificity against Type I Restriction–Modification Systems
AbstractThe ArdA DNA-mimic antirestriction proteins inhibit type I restriction−modification (RMI) systems by binding instead of DNA to RMI. The ArdA...
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LUBAC is required for RIG-I sensing of RNA viruses
The ability of cells to mount an interferon response to virus infections depends on intracellular nucleic acid sensing pattern recognition receptors...
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Untersuchung der Liganden-Bindung am MHC-Klasse I-Protein
Analysis of receptor-ligand interactions is fundamental for the understanding of many biological processes. Our main object of investigation are MHC...
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Uncovering the photosystem I assembly pathway in land plants
Photosystem I (PSI) is one of two large pigment–protein complexes responsible for converting solar energy into chemical energy in all oxygenic...
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Effects of Tetrodotoxin and Ranolazine on the Late INa of Zebrafish Ventricular Myocytes
AbstractThe inward Na + current (I Na ), generated by the voltage-gated Na + channels, can be divided into two components: the fast, transient peak...
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Inhibition of adenylyl cyclase by GTPase-deficient Gαi is mechanistically different from that mediated by receptor-activated Gαi
Signal transduction through G protein-coupled receptors (GPCRs) has been a major focus in cell biology for decades. Numerous disorders are associated...
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Determination, expression and characterization of an UDP-N-acetylglucosamine:α-1,3-D-mannoside β-1,2-N-acetylglucosaminyltransferase I (GnT-I) from the Pacific oyster, Crassostrea gigas
Molluscs are intermediate hosts for several parasites. The recognition processes, required to evade the host’s immune response, depend on...
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Lactobacillus rhamnosus GG Regulates Host IFN-I Through the RIG-I Signalling Pathway to Inhibit Herpes Simplex Virus Type 2 Infection
Numerous recent studies have demonstrated that the commensal microbiota plays an important role in host immunity against infections. During the...
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Part I: Conclusion
Rubus bogotensis Kunth is an underutilized fruit species from South America that has great potential for improvement in breeding programs. It has...
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Association of HLA Class I Genotype with Mortality in Patients with Diabetes Mellitus and COVID-19
AbstractNumerous studies showed that diabetes mellitus (DM) increases the risk of death from COVID-19 by five times. It is generally accepted that...
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The crucial regulatory role of type I interferon in inflammatory diseases
Type I interferon (IFN-I) plays crucial roles in the regulation of inflammation and it is associated with various inflammatory diseases including...
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High-throughput discovery of MHC class I- and II-restricted T cell epitopes using synthetic cellular circuits
Antigen discovery technologies have largely focused on major histocompatibility complex (MHC) class I-restricted human T cell receptors (TCRs),...
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Amino acid insertion in Bat MHC-I enhances complex stability and augments peptide presentation
Bats serve as reservoirs for numerous zoonotic viruses, yet they typically remain asymptomatic owing to their unique immune system. Of particular...
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Thymidine phosphorylase facilitates retinoic acid inducible gene-I induced endothelial dysfunction
Activation of nucleic acid sensors in endothelial cells (ECs) has been shown to drive inflammation across pathologies including cancer,...
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Growth phase-dependent reorganization of cryptophyte photosystem I antennae
Photosynthetic cryptophytes are eukaryotic algae that utilize membrane-embedded chlorophyll a/c binding proteins (CACs) and lumen-localized...
