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1. Elucidation of genetic determinants of dyslipidaemia using a global screening array for the early detection of coronary artery disease

   Dyslipidemia is a major risk factor for the development of coronary artery disease (CAD). Understanding the genetic determinants of dyslipidemia can...

   Ananthaneni Radhika, Sandeepta Burgula, ... Shaik Mohammad Naushad in Mammalian Genome

   Article 05 September 2023
   

2. Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

   Background

   Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways...

   Stavroula Kanoni, Sarah E. Graham, ... Gina M. Peloso in Genome Biology

   Article Open access 27 December 2022
   

3. Mutations in HNF1A Gene are not a Common Cause of Familial Young-Onset Diabetes in Iran

   Mutations in hepatocyte nuclear factor-1 alpha (HNF1A) as a homeodomain transcription factor which regulates variety of genes, are the most common...

   Meysam Moghbeli, Bahram Naghibzadeh, ... Mohammad Reza Abbaszadegan in Indian Journal of Clinical Biochemistry

   Article 13 April 2017
   

4. Associations of lipid levels susceptibility loci with coronary artery disease in Chinese population

   Background

   Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) that were associated with...

   Xue-bin Wang, Ya-di Han, ... Fang Zheng in Lipids in Health and Disease

   Article Open access 25 July 2015
   

5. Genetic determinants of inherited susceptibility to hypercholesterolemia – a comprehensive literature review

   Hypercholesterolemia is a strong determinant of mortality and morbidity associated with cardiovascular diseases and a major contributor to the global...

   CS Paththinige, ND Sirisena, VHW Dissanayake in Lipids in Health and Disease

   Article Open access 02 June 2017
   

6. Interactions of genetic and non-genetic factors on plasma hs-CRP concentration in a Korean community-based cohort study

   High sensitivity C-reactive protein (hs-CRP) level is a predictor of cardiovascular disease. We investigated gene-environment interactions that...

   Eun Pyo Hong, Dong-Hyun Kim, Ji Wan Park in Genes & Genomics

   Article 08 November 2014
   

7. Effect of interactions between genetic polymorphisms and cigarette smoking on plasma triglyceride levels in elderly Koreans: the Hallym Aging Study

   High triglyceride (TG) levels are known to be associated with complex diseases such as cardiovascular disease. Here, we evaluated the effect of...

   Eun Pyo Hong, Ji Wan Park, ... Dong-Hyun Kim in Genes & Genomics

   Article 28 October 2014
   

8. Whole genome sequencing of Turkish genomes reveals functional private alleles and impact of genetic interactions with Europe, Asia and Africa

   Background

   Turkey is a crossroads of major population movements throughout history and has been a hotspot of cultural interactions. Several studies...

   Can Alkan, Pinar Kavak, ... Cemalettin Bekpen in BMC Genomics

   Article Open access 07 November 2014
   

9. An association-adjusted consensus deleterious scheme to classify homozygous Mis-sense mutations for personal genome interpretation

   Background

   Personal genome analysis is now being considered for evaluation of disease risk in healthy individuals, utilizing both rare and common...

   Thanawadee Preeprem, Greg Gibson in BioData Mining

   Article Open access 23 December 2013
   

10. Analyses of longitudinal effects of gene-environment interactions on plasma C-reactive protein levels: the Hallym Aging Study

    High C-reactive protein (CRP) level (above 3 mg/L), an inflammatory biomarker, is a well-known risk factor for cardiovascular disease. We...

    Eun Pyo Hong, Dong-Hyun Kim, ... Ji Wan Park in Genes & Genomics

    Article 29 January 2013
    

11. Identification of Type 2 Diabetes-associated combination of SNPs using Support Vector Machine

    Background

    Type 2 diabetes mellitus (T2D), a metabolic disorder characterized by insulin resistance and relative insulin deficiency, is a complex...

    Hyo-Jeong Ban, Jee Yeon Heo, ... Keun-Joon Park in BMC Genetics

    Article Open access 23 April 2010