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ER-mitochondria contact sites in neurodegeneration: genetic screening approaches to investigate novel disease mechanisms
Mitochondria-ER contact sites (MERCS) are known to underpin many important cellular homoeostatic functions, including mitochondrial quality control,...
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Identification of potent anti-immunogenic agents through virtual screening, 3D-QSAR studies, and in vitro experiments
A wealth of literature has highlighted the discovery of various immune modulators, frequently used in clinical practice, yet associated with numerous...
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Development of antibody to virulence factor flagellin and its evaluation in screening Ralstonia pseudosolanacearum
The bacterial wilt disease caused by Ralstonia pseudosolanacearum presents a notable economic risk to a variety of crucial crops worldwide. During...
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Screening of ridge gourd genotypes for resistance to downy mildew (Pseudoperonospora cubensis)
Downy mildew caused by Pseudoperonospora cubensis is one of the major production constraints of ridge gourd cultivation causing severe yield loss....
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Screening of ulcerative colitis biomarkers and potential pathways based on weighted gene co-expression network, machine learning and ceRNA hypothesis
BackgroundUlcerative colitis (UC) refers to an intractable intestinal inflammatory disease. Its increasing incidence rate imposes a huge burden on...
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A fully 3D-printed versatile tumor-on-a-chip allows multi-drug screening and correlation with clinical outcomes for personalized medicine
Optimal clinical outcomes in cancer treatments could be achieved through the development of reliable, precise ex vivo tumor models that function as...
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Virtual screening of FOXO3a activators from natural product-like compound library
FOXO3a is an inevitable transcription factor, which is involved in the regulation of biological processes such as proliferation, DNA damage repair,...
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Discovery of a novel DYRK1A inhibitor with neuroprotective activity by virtual screening and in vitro biological evaluation
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is implicated in accumulation of amyloid β-protein (Aβ) and phosphorylation of...
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Classification of likely functional class for ligand binding sites identified from fragment screening
Fragment screening is used to identify binding sites and leads in drug discovery, but it is often unclear which binding sites are functionally...
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Multi-criteria decision analysis for supporting the selection of subclinical mastitis screening tests to use in large- and small-scale dairy farms in Türkiye
The production of high-quality and safe milk is closely associated with the udder health of dairy cows. While there are many mastitis diagnostic...
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Appraisal for multiple disease resistance in advanced breeding lines of tomato (Solanum lycopersicum L.)
The leaf curl disease (ToLCD), late blight (LB) and root knot nematode (RKN) are the major obstacles for rainy season tomato production all over the...
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Breeding for black rot resistance in grapevine: advanced approaches for germplasm screening
Crop improvement by means of traditional or molecular breeding is a key strategy to accomplish the European Green Deal target of reducing pesticides...
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Pharmacoinformatic Analysis of Drug Leads for Alzheimer’s Disease from FDA-Approved Dataset Through Drug Repositioning Studies
Drug design is highly priced and time-consuming procedure. Therefore, to overcome this problem, in silico drug design methods, particularly drug...
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Abnormal EEG microstates in Alzheimer’s disease: predictors of β-amyloid deposition degree and disease classification
Electroencephalography (EEG) microstates are used to study cognitive processes and brain disease-related changes. However, dysfunctional patterns of...
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Disease Resistance
Wheat plants are infected by diverse pathogens of economic significance. They include biotrophic pathogens like mildews and rusts that require living...
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Virtual Screening Technique to Identify Inhibitors of Mycobacterium tuberculosis Rv3032 Protein Involved in MGLP Biosynthesis
AbstractObjective: Tuberculosis (TB) is a contagious disease caused by Mycobacterium tuberculosis , that poses a threat to the international...
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Predicting potential miRNA-disease associations based on more reliable negative sample selection
BackgroundIncreasing biomedical studies have shown that the dysfunction of miRNAs is closely related with many human diseases. Identifying...
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Multi-method computational evaluation of the inhibitors against leucine-rich repeat kinase 2 G2019S mutant for Parkinson's disease
Leucine-rich repeat kinase 2 G2019S mutant (LRRK2 G2019S) is a potential target for Parkinson's disease therapy. In this work, the computational...
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In silico screening of neurokinin receptor antagonists as a therapeutic strategy for neuroinflammation in Alzheimer’s disease
Neuroinflammation is one of the detrimental factors leading to neurodegeneration in Alzheimer’s disease (AD) and other neurodegenerative disorders....
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Effect of phosphorous acid on late blight disease mitigation and minimization of fungicide doses under field conditions
Late blight disease, caused by Phytophthora infestans , is a consistent challenge in potato-growing regions of the world. In the current scenario of...
