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Reenacting the Birth of a Function: Functional Divergence of HIUases and Transthyretins as Inferred by Evolutionary and Biophysical Studies
Transthyretin was discovered in the 1940s, named after its ability to bind thyroid hormones and retinol. In the genomic era, transthyretins were...
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Structural basis for bacterial lipoprotein relocation by the transporter LolCDE
Lipoproteins in the outer membrane of Gram-negative bacteria are involved in various vital physiological activities, including multidrug resistance....
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Waterfowl and Wetland Birds
The future of wetland bird habitat and populations is intrinsically connected with the conservation of rangelands in North America. Many rangeland...
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High-Resolution Tomography, Molecular Model Building and Visualization
A long sought-after goal in cellular biology is to be able to visualize macromolecular complexes inside cells at resolutions that are sufficient to...
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Polymerization of the backbone of the pectic polysaccharide rhamnogalacturonan I
Rhamnogalacturonan I (RG-I) is a major plant cell wall pectic polysaccharide defined by its repeating disaccharide backbone structure of [4)-α- d -GalA-(1,2)-α-...
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Broad-spectrum ubiquitin/ubiquitin-like deconjugation activity of the rhizobial effector NopD from Bradyrhizobium (sp. XS1150)
The post-translational modification of proteins by ubiquitin-like modifiers (UbLs), such as SUMO, ubiquitin, and Nedd8, regulates a vast array of...
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Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China
The H5N8 avian influenza viruses have been widely circulating in wild birds and are responsible for the loss of over 33 million domestic poultry in...
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The NTE domain of PTENα/β promotes cancer progression by interacting with WDR5 via its SSSRRSS motif
PTENα/β, two variants of PTEN, play a key role in promoting tumor growth by interacting with WDR5 through their N-terminal extensions (NTEs). This...
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Structural basis for excitatory neuropeptide signaling
Rapid signaling between neurons is mediated by ligand-gated ion channels, cell-surface proteins with an extracellular ligand-binding domain and a...
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A new and promiscuous α/β hydrolase from Acinetobacter tandoii DSM 14970 T inactivates the mycotoxin ochratoxin A
AbstractThe presence of ochratoxin A (OTA) in food and feed represents a serious concern since it raises severe health implications. Bacterial...
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Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome
SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with...
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Seasonal changes in the structure of bird assemblages in tide-dominated marine coastal wetlands of Chiloe Archipelago (Chilean Northern Patagonia, South America)
The coastal wetlands of northern Chilean Patagonia are relevant sites for the conservation of migratory waterbirds. The aim of this paper is to...
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Structural basis and mechanism of activation of two different families of G proteins by the same GPCR
The β 1 -adrenergic receptor (β 1 -AR) can activate two families of G proteins. When coupled to Gs, β 1 -AR increases cardiac output, and coupling to Gi...
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Structure of a membrane tethering complex incorporating multiple SNAREs
Most membrane fusion reactions in eukaryotic cells are mediated by multisubunit tethering complexes (MTCs) and SNARE proteins. MTCs are much larger...
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How on Earth did that get there? Natural and human vectors of aquatic macrophyte global distribution
No previous study has examined the large-scale distributional drivers of the entire global pool of 3,499 macrophyte species, despite the obvious...
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The protein conformational basis of isoflavone biosynthesis
Isoflavonoids play important roles in plant defense and also exhibit a range of mammalian health-promoting activities. Their biosynthesis is...
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Transport and inhibition mechanism of the human SGLT2–MAP17 glucose transporter
Sodium–glucose cotransporter 2 (SGLT2) is imporant in glucose reabsorption. SGLT2 inhibitors suppress renal glucose reabsorption, therefore reducing...
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Crossroad for bird migration: France should improve the conservation of its key-wetland sites used by 6 million waterbirds
Abundance of wild species is generally used to prioritize and evaluate networks of protected areas (PAs). Waterbird abundance information, collected...
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Glycan shield of the ebolavirus envelope glycoprotein GP
The envelope glycoprotein GP of the ebolaviruses is essential for host cell entry and the primary target of the host antibody response. GP is heavily...
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Life Cycle of the Trematode Gynaecotyla adunca (Trematoda: Microphallidae) in the Black Sea
Abstract —The complete life cycle and the stages in the trematode Gynaecotyla adunca (Linton, 1905) (Yamaguti, 1939) from two different biotopes are...
