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A Country Through Crisis and Beyond: The Case of the Greek Landscape
This chapter critically explores the relationship of Greeks to their landscape, attempting to make sense of the aspects of this relationship in its...
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msPIPE: a pipeline for the analysis and visualization of whole-genome bisulfite sequencing data
BackgroundDNA methylation is an important epigenetic modification that is known to regulate gene expression. Whole-genome bisulfite sequencing (WGBS)...
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Maternal SMCHD1 controls both imprinted **st expression and imprinted X chromosome inactivation
Embryonic development is dependent on the maternal supply of proteins through the oocyte, including factors setting up the adequate epigenetic...
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Haplotype-aware pantranscriptome analyses using spliced pangenome graphs
Pangenomics is emerging as a powerful computational paradigm in bioinformatics. This field uses population-level genome reference structures,...
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Synthetic DNA fragments bearing ICR cis elements become differentially methylated and recapitulate genomic imprinting in transgenic mice
BackgroundGenomic imprinting is governed by allele-specific DNA methylation at imprinting control regions (ICRs), and the mechanism controlling its...
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Recent advances in chromosome capture techniques unraveling 3D genome architecture in germ cells, health, and disease
In eukaryotes, the genome does not emerge in a specific shape but rather as a hierarchial bundle within the nucleus. This multifaceted genome...
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The Utility of Twins for Epigenetic Analysis
Twin studies have played an important role in our understanding of individual variation for over a century. The strength of these lies in the...
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Association between placental DNA methylation and fetal congenital heart disease
Congenital heart disease (CHD) is a worldwide problem with high morbidity and mortality. Early diagnosis of congenital heart disease is still a...
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Effects of paternal exposure to cigarette smoke on sperm DNA methylation and long-term metabolic syndrome in offspring
BackgroundAlthough paternal exposure to cigarette smoke may contribute to obesity and metabolic syndrome in offspring, the underlying mechanisms...
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Recapitulation of gametic DNA methylation and its post-fertilization maintenance with reassembled DNA elements at the mouse Igf2/H19 locus
BackgroundPaternal allele-specific DNA methylation of the H19 imprinting control region (ICR) regulates imprinted expression of the Igf 2/ H19 genes....
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Major Research Achievements
The successful implementation of this MRP has promoted the overall improvement and leapfrog development of the epigenetic research in China.
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QTL Regions and Candidate Genes Associated with Selected Morphological Traits of Winter Triticale (× Triticosecale) Seedlings
The development and viability of seedlings are crucial in overwintering cereals, as it can affect not only an adult plant physiological condition,...
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Clinical Studies and Epi-Drugs in Various Cancer Types
Cancer is characterized by modifications in the epigenetic mechanisms and chromatin functions. Alterations in gene expression, as well as the...
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DNA demethylation affects imprinted gene expression in maize endosperm
BackgroundDNA demethylation occurs in many species and is involved in diverse biological processes. However, the occurrence and role of DNA...
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Regulation of plant epigenetic memory in response to cold and heat stress: towards climate resilient agriculture
Plants have evolved to adapt and grow in hot and cold climatic conditions. Some also adapt to daily and seasonal temperature changes. Epigenetic...
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Epigenetic Alterations in Colorectal Cancer
Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the hallmarks of cancer and a fundamental trait of virtually all...
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Hereditary Conditions Associated with Elevated Cancer Risk in Childhood
AbstractWidespread use of the next-generation sequencing (NGS) technologies revealed that a significant percentage of tumors in children develop as a...
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GelMap: intrinsic calibration and deformation map** for expansion microscopy
Expansion microscopy (ExM) is a powerful technique to overcome the diffraction limit of light microscopy by physically expanding biological specimen...
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The Role of DNA Methylation and DNA Methyltransferases in Cancer
The malignant transformation of normal cells is driven by both genetic and epigenetic changes. With the advent of next-generation sequencing and...
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Epigenetics, Evolution and Development of Birds
In this chapter, we summarise the contribution of research in birds to the field of epigenetics and development, both from the Waddingtonian and...