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Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo
The apical junctional complex (AJC), composed of tight and adherens junctions, maintains epithelial barrier function. Since cigarette smoking and...
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Genomic profiling of tumor initiating prostatospheres
BackgroundThe cancer stem cell (CSC) hypothesis proposes that a population of tumor cells bearing stem cell properties is responsible for the origin...
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The claudins
The claudin multigene family encodes tetraspan membrane proteins that are crucial structural and functional components of tight junctions, which have...
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The association of CD81 with tetraspanin-enriched microdomains is not essential for Hepatitis C virus entry
BackgroundThree percent of the world's population is chronically infected with hepatitis C virus (HCV) and thus at risk of develo** liver cancer....
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Establishment of a human neonatal hepatocyte cell line
Hepatocytes are routinely used to generate and identify drug metabolites and hepatic toxicity. Primary cultures of human hepatocytes are the model...
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Claudin-8 and -27 tight junction proteins in puffer fish Tetraodon nigroviridis acclimated to freshwater and seawater
Genes encoding for claudin-8 and -27 tight junction proteins in the euryhaline puffer fish ( Tetraodon nigroviridis ) were identified using its...
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The genomic basis of the Williams – Beuren syndrome
The Williams-Beuren syndrome is a genomic disorder (prevalence: 1/7,500 to 1/20,000), caused by a hemizygous contiguous gene deletion on chromosome...
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Organization of the pronephric kidney revealed by large-scale gene expression map**
BackgroundThe pronephros, the simplest form of a vertebrate excretory organ, has recently become an important model of vertebrate kidney...
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A critical analysis of disease-associated DNA polymorphisms in the genes of cattle, goat, sheep, and pig
Genetic variations through their effects on gene expression and protein function underlie disease susceptibility in farm animal species. The...
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The Cytoplasmic Tails of Claudins Can Influence Tight Junction Barrier Properties through Effects on Protein Stability
The tight junction seal formed between epithelial cells varies among tissues in both tightness and ionic charge selectivity. We recently demonstrated...
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Regulation of the Expression of the Prostate-specific Antigen by Claudin-7
Claudins are a family of proteins involved in forming tight junctions between cells. Here we describe two forms of claudin-7 (CLDN-7), a full-length...
