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Synthesis of Novel 2-((3-(Benzofuran-2-yl)-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazinyl-4-phenylthiazole: Potent EGFR Targeting Anticancer Agents
AbstractObjective: Benzofurans, fused pyrazole systems, and thiazole moieties are the most important pharmacophores and intermediates for making...
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Oxysterols in Cell Viability, Phospholipidosis and Extracellular Vesicles Production in a Lung Cancer Model
The study carried out systematic research on the influence of selected oxysterols on cells viability, phospholipidosis and the level of secreted...
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Ferroptotic alveolar epithelial type II cells drive TH2 and TH17 mixed asthma triggered by birch pollen allergen Bet v 1
Asthma is a common allergic disease characterized by airway hypersensitivity and airway remodeling. Ferroptosis is a regulated death marked by iron...
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Synthesis of Morpholine Linked Indole-1,2,3-triazole Hybrids as In Vitro Tubulin Polymerization Inhibiting Agents
AbstractObjective: Synthesis of some new some new morpholine linked indole-1,2,3-triazole hybrids and evaluation of their anti-cancer activity. ...
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Apoptosis induction in human lung and colon cancer cells via impeding VEGF signaling pathways
There is ample evidence to suggest that vascular endothelial growth factor (VEGF) is a potent mitogen factor in vasculogenesis and angiogenesis and...
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Discovery of Palbociclib as a potent c-Myc G4 stabilizer for lung cancer treatment using molecular docking, molecular dynamics simulation, and in vitro activity evaluation
Despite significant progress in lung cancer treatment, this disease remains a prevalent and serious global malignancy, leading to high rates of...
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Chemical Compositions of Houttuynia cordata Thunb. Volatile Oil and Its Analogues Attenuate Staphylococcus aureus Virulence by Targeting α-Hemolysin
AbstractHouttuynia cordata Thunb. is a medicinal and edible plant that has been used to treat phlegm, asthma, cough, carbuncle, swelling, and sore...
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Extracellular vesicles derived from CD4+ T cells carry DGKK to promote sepsis-induced lung injury by regulating oxidative stress and inflammation
BackgroundSepsis is an abnormal immune response after infection, wherein the lung is the most susceptible organ to fail, leading to acute lung...
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Anlotinib affects systemic lipid metabolism and induces lipid accumulation in human lung cancer cells
BackgroundAnlotinib has demonstrated encouraging clinical outcomes in the treatment of lung cancer, soft tissue sarcoma and thyroid carcinoma....
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S100A8/A9-RAGE pathway and chronic airway inflammation in smoke-induced lung carcinogenesis
BackgroundCigarette smoke-induced chronic airway inflammation increases the risk of lung cancer and plays a multifaceted role in lung cancer...
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Methylation of hypoxia-inducible factor 3 subunit alpha contributes to poor prognosis in lung adenocarcinoma
Hypoxia-inducible factor 3 subunit alpha (HIF3A) has been implicated in various types of cancers, while its precise role in the lung adenocarcinoma...
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Basic Fibroblast Growth Factor Accumulation in Culture Medium Masks the Direct Antitumor Effect of Anti-VEGF Agent Bevacizumab
AbstractThe direct antitumor effect of bevacizumab (BEV) has long been debated. Evidence of the direct antitumor activities of drugs are mainly...
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Boron Compound–Based Treatments Against Multidrug-Resistant Bacterial Infections in Lung Cancer In Vitro Model
Multidrug-resistant bacteria is one of the most important public health problems. Increasing rates of antibacterial resistance also affect the...
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KCNAB2 overexpression inhibits human non-small-cell lung cancer cell growth in vitro and in vivo
Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancer cases. NSCLC patients often have poor prognosis demanding urgent...
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USP28 promotes tumorigenesis and cisplatin resistance by deubiquitinating MAST1 protein in cancer cells
Cisplatin is a chemotherapy drug that causes a plethora of DNA lesions and inhibits DNA transcription and replication, resulting in the induction of...
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M6PR interacts with the HA2 subunit of influenza A virus to facilitate the fusion of viral and endosomal membranes
Influenza A virus (IAV) commandeers numerous host cellular factors for successful replication. However, very few host factors have been revealed to...
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Forskolin Enhances Antitumor Effect of Oncolytic Measles Virus by Promoting Rab27a Dependent Vesicular Transport System
The measles vaccine virus strain (MV-Edm) serves as a potential platform for the development of effective oncolytic vectors. Nevertheless, despite...
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Activation of ERK/NF-kB Pathways Contributes to the Inflammatory Response in Epithelial Cells and Macrophages Following Manganese Exposure
Different types of metals, including manganese (Mn), are constantly encountered in various environmental matrices due to natural and anthropogenic...
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Ornidazole Inhibits the Angiogenesis and Migration Abilities of Non-small Cell Lung
Background: Around the world, non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths among all cancers. Despite...
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MBD2 facilitates tumor metastasis by mitigating DDB2 expression
Despite past extensive studies, the pathoetiologies underlying tumor metastasis remain poorly understood, which renders its treatment largely...
