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The Cavin-1/Caveolin-1 interaction attenuates BMP/Smad signaling in pulmonary hypertension by interfering with BMPR2/Caveolin-1 binding
Caveolin-1 (CAV1) and Cavin-1 are components of caveolae, both of which interact with and influence the composition and stabilization of caveolae....
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Insulin induces insulin receptor degradation in the liver through EphB4
Insulin signaling is essential for glucose metabolism, and insulin decreases insulin receptor (InsR) levels in a dose-dependent and time-dependent...
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The human OPA1delTTAG mutation induces adult onset and progressive auditory neuropathy in mice
Dominant optic atrophy (DOA) is one of the most prevalent forms of hereditary optic neuropathies and is mainly caused by heterozygous variants in OPA1 ...
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The lysosome as an imperative regulator of autophagy and cell death
Lysosomes are single membrane-bound organelles containing acid hydrolases responsible for the degradation of cellular cargo and maintenance of...
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The emerging mechanisms and functions of microautophagy
‘Autophagy’ refers to an evolutionarily conserved process through which cellular contents, such as damaged organelles and protein aggregates, are...
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Functional Diversity of Macropinocytosis
Eukaryotic cells are capable of internalizing different types of cargo by plasma membrane ruffling and forming vesicles in a process known as...
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MICAL2 contributes to gastric cancer cell migration via Cdc42-dependent activation of E-cadherin/β-catenin signaling pathway
BackgroundGastric cancer is a common and lethal human malignancy worldwide and cancer cell metastasis is the leading cause of cancer-related...
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The Internalization and Intracellular Trafficking of ADCs
Internalization is thought to be an important process during the antibody-based therapeutics. As ADC internalizes, it is transported to lysosome for...
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Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy
Autophagy-mediated lipotoxicity plays a critical role in the progression of diabetic nephropathy (DN), but the precise mechanism is not fully...
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Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation
Lysosomes are central platforms for not only the degradation of macromolecules but also the integration of multiple signaling pathways. However,...
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The Alzheimer’s gene SORL1 is a regulator of endosomal traffic and recycling in human neurons
BackgroundLoss of the Sortilin-related receptor 1 ( SORL1 ) gene seems to act as a causal event for Alzheimer’s disease (AD). Recent studies have...
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Dynamic regulation of KIF15 phosphorylation and acetylation promotes focal adhesions disassembly in pancreatic cancer
Pancreatic cancer (PC) is prone to distant metastasis in the early stage, which is attributed to the strong migration ability of tumor cells. Focal...
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PFKFB3 inhibition reprograms malignant pleural mesothelioma to nutrient stress-induced macropinocytosis and ER stress as independent binary adaptive responses
The metabolic signatures of cancer cells are often associated with elevated glycolysis. Pharmacological (PFK158 treatment) and genetic inhibition of...
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Emerging role of lipophagy in liver disorders
Lipophagy is a selective degradation of lipids by a lysosomal-mediated pathway, and dysregulation of lipophagy is linked with the pathological...
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Phagolysosome resolution requires contacts with the endoplasmic reticulum and phosphatidylinositol-4-phosphate signalling
Phosphoinositides have a pivotal role in the maturation of nascent phagosomes into microbicidal phagolysosomes. Following degradation of their...
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MSC-Derived Exosomes: Advances in Cell-Free Therapy
Mesenchymal stem cells (MSCs)Mesenchymal stem cells (MSCs) are a rich source of bioactive molecules, which they secrete as a part of their paracrine...
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Roles for 3’ Phosphoinositides in Macropinocytosis
The distinct movements of macropinosome formation and maturation have corresponding biochemical activities which occur in a defined sequence of...
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Invasion by exogenous RNA: cellular defense strategies and implications for RNA inference
Exogenous RNA poses a continuous threat to genome stability and integrity across various organisms. Accumulating evidence reveals complex mechanisms...
