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Deciphering the Epigenetic Landscape: Placental Development and Its Role in Pregnancy Outcomes
The placenta stands out as a unique, transitory, and multifaceted organ, essential to the optimal growth and maturation of the fetus. Functioning as...
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Health Effects of Aflatoxins in Fetus, Infants, and Children
Aflatoxins are group 1 category carcinogenic compound that are reported in several food commodities well beyond the maximum permissible limits. Early...
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Prenatal Maternal Low Selenium, High Thyrotropin, and Low Birth Weights
In consideration of the potential roles of selenoproteins in thyroid function, we aimed to evaluate the association of low selenium status with...
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Which is the optimal choice for neonates’ formula or breast milk?
The incidence of prematurity has been increasing since the twenty-first century. Premature neonates are extremely vulnerable and require a rich...
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Stem/progenitor cells in fetuses and newborns: overview of immunohistochemical markers
Microanatomy of the vast majority of human organs at birth is characterized by marked differences as compared to adult organs, regarding their...
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Climatic and calf-related risk factors associated with failure of transfer of passive immunity in Holstein calves in a hot environment
This retrospective observational study aimed to assess the effect of temperature-humidity index (THI) at calving and in the last trimester of...
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LOX overexpression programming mediates the osteoclast mechanism of low peak bone mass in female offspring rats caused by pregnant dexamethasone exposure
BackgroundOsteoporosis is a degenerative disease characterized by reduced bone mass, with low peak bone mass being the predominant manifestation...
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Effect of autologous bone marrow stem cells-scaffold transplantation on the ongoing pregnancy rate in intrauterine adhesion women: a randomized, controlled trial
Intrauterine adhesion is a major cause of female reproductive disorders. Although we and others uncontrolled pilot studies showed that treatment with...
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Vaginal microbiome Lactobacillus crispatus is heritable among European American women
The diversity and dominant bacterial taxa in the vagina are reported to be influenced by multiple intrinsic and extrinsic factors, including but not...
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Effectiveness of extracellular vesicles derived from hiPSCs in repairing hyperoxia-induced injury in a fetal murine lung explant model
BackgroundDespite advances in neonatal care, the incidence of Bronchopulmonary Dysplasia (BPD) remains high among preterm infants. Human induced...
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Device Fabrication and Fluorescent Labeling of Preterm Birth Biomarkers for Microchip Electrophoresis
An unmet need exists for a clinical diagnostic to determine preterm birth (PTB) risk. Such an assessment is possible with high sensitivity and...
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Associations of the placental metabolome with immune maturation up to one year of age in the Swedish NICE-cohort
IntroductionAllergies and other immune-mediated diseases are thought to result from incomplete maturation of the immune system early in life. We...
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Fecal filtrate transplantation protects against necrotizing enterocolitis
Necrotizing enterocolitis (NEC) is a life-threatening gastrointestinal disorder afflicting preterm infants, which is currently unpreventable. Fecal...
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Maternal hypercholesterolemia during gestation is associated with elevated lipid levels of two-day-old neonates
Maternal hypercholesterolemia (MHC) during pregnancy is associated with the risk of develo** aortic lesions in fetuses. There is also a possibility...
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Sex differences in DNA methylation across gestation: a large scale, cross-cohort, multi-tissue analysis
Biological sex is a key variable influencing many physiological systems. Disease prevalence as well as treatment success can be modified by sex....
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Childhood-related neural genotype–phenotype in ATP1A3 mutations: comprehensive analysis
BackgroundATP1A3 is a gene that encodes the ATPase Na + /K + transporting subunit alpha-3 isoenzyme that is widely expressed in GABAergic neurons....
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Associations between maternal serum HDL-c concentrations during pregnancy and neonatal birth weight: a population-based cohort study
BackgroundTo evaluate the associations between maternal serum concentrations of high-density lipoprotein cholesterol (HDL-c) throughout pregnancy and...
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The Technical and Ethical Framework of Fetal Therapy: Past and Current Advances
Purpose of ReviewFetal therapy, a burgeoning field that encompasses prenatal surgical and medical interventions for congenital diseases, enables...
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Extracellular vesicles from vaginal Gardnerella vaginalis and Mobiluncus mulieris contain distinct proteomic cargo and induce inflammatory pathways
Colonization of the vaginal space with bacteria such as Gardnerella vaginalis and Mobiluncus mulieris is associated with increased risk for STIs,...
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Bacterial vaginosis and health-associated bacteria modulate the immunometabolic landscape in 3D model of human cervix
Bacterial vaginosis (BV) is an enigmatic polymicrobial condition characterized by a depletion of health-associated Lactobacillus and an overgrowth of...
