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Restoring mitochondrial cardiolipin homeostasis reduces cell death and promotes recovery after spinal cord injury
Alterations in phospholipids have long been associated with spinal cord injury (SCI). However, their specific roles and signaling cascades in...
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The effect of space travel on human reproductive health: a systematic review
With increasing possibilities of multi-year missions in deep space, colonizing other planets, and space tourism, it is important to investigate the...
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Developmental, physiologic and phylogenetic perspectives on the expression and regulation of myosin heavy chains in mammalian skeletal muscles
The kinetics of myosin controls the speed and power of muscle contraction. Mammalian skeletal muscles express twelve kinetically different myosin...
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A deep learning-based toolbox for Automated Limb Motion Analysis (ALMA) in murine models of neurological disorders
In neuroscience research, the refined analysis of rodent locomotion is complex and cumbersome, and access to the technique is limited because of the...
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Myosatellite Cells under Gravitational Unloading Conditions
AbstractSkeletal muscles are well known to have a high degree of plasticity. Gravitational unloading has a strong impact on the structural...
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The effects of microgravity on bone structure and function
Humans are spending an increasing amount of time in space, where exposure to conditions of microgravity causes 1–2% bone loss per month in...
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3D printing of injury-preconditioned secretome/collagen/heparan sulfate scaffolds for neurological recovery after traumatic brain injury in rats
BackgroundThe effects of traumatic brain injury (TBI) can include physical disability and even death. The development of effective therapies to...
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Muscle-specific activation of calpain system in hindlimb unloading rats and hibernating Daurian ground squirrels: a comparison between artificial and natural disuse
To determine whether the regulation of calpain system is involved in non-hibernators and hibernators in disused condition, the soleus (SOL) and...
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Hind Limb Bone Proportions Reveal Unexpected Morphofunctional Diversification in Xenarthrans
Divergence in forelimb morphology is often associated with functional habits exhibited within the Xenarthra, ranging from terrestrial-digging in...
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Targeted silencing of miRNA-132-3p expression rescues disuse osteopenia by promoting mesenchymal stem cell osteogenic differentiation and osteogenesis in mice
BackgroundSkeletal unloading can induce severe disuse osteopenia that often occurs in spaceflight astronauts or in patients subjected to prolonged...
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Dedifferentiated fat cells: current applications and future directions in regenerative medicine
Stem cell therapy is the most promising treatment option for regenerative medicine. Therapeutic effect of different stem cells has been verified in...
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The roles of neural stem cells in myelin regeneration and repair therapy after spinal cord injury
Spinal cord injury (SCI) is a complex tissue injury that results in a wide range of physical deficits, including permanent or progressive...
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Hnrnpk is essential for embryonic limb bud development as a transcription activator and a collaborator of insulator protein Ctcf
Proper development of the limb bud relies on the concordance of various signals, but its molecular mechanisms have not yet been fully illustrated....
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Macrophages upregulate mural cell-like markers and support healing of ischemic injury by adopting functions important for vascular support
Sterile inflammation after injury is important for tissue restoration. In injured human and mouse tissues, macrophages were recently found to...
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Birds
The vertebrate Bauplan has undergone a very particular evolution in the class of Aves. Irrespective of the enormous variation in colour, plumage,...
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Nerve growth factor (NGF) with hypoxia response elements loaded by adeno-associated virus (AAV) combined with neural stem cells improve the spinal cord injury recovery
The ischemia and hypoxia microenvironment after spinal cord injury (SCI) makes SCI repair a challenging problem. With various stimulus, chances for...
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Primates: The Group Including Humans
Primates are a diverse group of mammals, difficult to describe in few, short words. They vary in size between 50 grammes (Microcebus, Cebuella) and...
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Production and Application of Mesenchymal Stem Cell Spheroids for Cartilage and Bone Regeneration
Introduction: Cartilage and bone tissues are widely utilized in regenerative medicine, especially in treating injured cartilage and bone. Some...
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Combined intramuscular and intraspinal transplant of bone marrow cells improves neuromuscular function in the SOD1G93A mice
BackgroundThe simultaneous contribution of several etiopathogenic disturbances makes amyotrophic lateral sclerosis (ALS) a fatal and challenging...
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Contingent intramuscular boosting of P2XR7 axis improves motor function in transgenic ALS mice
Amyotrophic lateral sclerosis is a fatal neurodegenerative disorder that leads to progressive degeneration of motor neurons and severe muscle atrophy...
