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Promotion of stem cell-like phenotype of lung adenocarcinoma by FAM83A via stabilization of ErbB2
Lung cancer stands as the leading cause of mortality among all types of tumors, with over 40% of cases being lung adenocarcinoma (LUAD). Family with...
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Coupled folding-upon-binding of human tumor suppressor MIG6 to lung cancer EGFR kinase domain and molecular trimming/stapling of MIG6-derived β-hairpins to target the coupling event
Human epidermal growth factor receptor (EGFR) is involved in strong association with malignant proliferation, which has been shown to play a central...
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Anticancer activity of herbal formula Jisilhaebaekgyeji-Tang against human breast cancer cells and its mechanism
BackgroundJisilhaebaekgyeji-Tang (JHG, Zhishi **ebai Guizhi Tang ) is a famous traditional herbal medicine described in the Geumgweyoryak ( ** Gui...
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Glioblastoma Therapy: Rationale for a Mesenchymal Stem Cell-based Vehicle to Carry Recombinant Viruses
Evasion of growth suppression is among the prominent hallmarks of cancer. Phosphatase and tensin homolog (PTEN) and p53 tumor-suppressive pathways...
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Targeted inhibition of eIF5Ahpu suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer
Eukaryotic initiation factor 5A2 (eIF5A2) is overexpressed in many types of cancer, and spermidine-mediated eIF5A hypusination (eIF5A hpu ) appears to...
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Isolation and Maintenance in Culture of Primary Human Trophoblast from Term Placentae
Trophoblasts are placenta-specific epithelial cells that play an essential role in conducting nutrient, gas, and waste exchange between the fetus and...
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Towards a Continuous Production of Human Mesenchymal Stromal Cells in a Chemically Defined Medium: Opportunities and Challenges for a Robust and Scalable Expansion Process
Human mesenchymal stromal cells (hMSCs) are one of the most prominent cell types used for cell therapy application. Thereby the current clinical...
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The role of amphiregulin in ovarian function and disease
AbstractAmphiregulin (AREG) is an epidermal growth factor (EGF)-like growth factor that binds exclusively to the EGF receptor (EGFR). Treatment with...
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Production, expression, and function of dual-specific monoclonal antibodies in a single plant
Main conclusionLSC CO17-1AK and anti-HER2 VHH-FcK can be produced in a single plant and exhibit anti-tumor activities comparable to those of their...
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Transcription Factor Sp1 in the Expression of Genes Encoding Components of Mapk, JAK/STAT, and PI3K/Akt Signaling Pathways
Sp1 is a transcription factor of the Sp/KLF family that binds to GC-rich motifs in regulatory regions of genes. Sp1 is involved in the regulation of...
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GREM1 signaling in cancer: tumor promotor and suppressor?
AbstractGREMLIN1 (GREM1) is member of a family of structurally and functionally related secreted cysteine knot proteins, which act to sequester and...
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Current advances and future prospects in production of recombinant insulin and other proteins to treat diabetes mellitus
Diabetes mellitus is the most prevalent deadly disease caused by the destruction and dysfunction of pancreatic β cells that consequentially increased...
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EGFR inhibits TNF-α-mediated pathway by phosphorylating TNFR1 at tyrosine 360 and 401
Tumour necrosis factor receptor 1 (TNFR1) induces the nuclear factor kappa-B (NF-κB) signalling pathway and regulated cell death processes when TNF-α...
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Growth factor therapy for cardiac repair: an overview of recent advances and future directions
Heart disease represents a significant public health burden and is associated with considerable morbidity and mortality at the level of the...
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Extra-hematopoietic immunomodulatory role of the guanine-exchange factor DOCK2
Stromal cells interact with immune cells during initiation and resolution of immune responses, though the precise underlying mechanisms remain to be...
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Anti-inflammatory and relaxation effects of Ulmus pumilla L. on EGF-inflamed bronchial epithelial and asthmatic bronchial smooth muscle cells
BackgroundUlmus Pumila L. (UPL), the roots of a tree species of elm, has been prescribed for immunity-related diseases, such as dermatitis,...
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Isolation of Epidermal Keratinocytes from Human Skin: The Scratch-Wound Assay for Assessment of Epidermal Keratinocyte Migration
The migration of epidermal keratinocytes is the basis for skin reepithelialization during wound healing. The in vitro scratch-wound assay using...
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In planta expression of human polyQ-expanded huntingtin fragment reveals mechanisms to prevent disease-related protein aggregation
In humans, aggregation of polyglutamine repeat (polyQ) proteins causes disorders such as Huntington’s disease. Although plants express hundreds of...
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Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization
The skin, which serves as the first barrier of the human body, is particularly susceptible to exogenous injuries. Skin wounds, including acute burns...
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PHLDA1 promotes glioblastoma cell growth via sustaining the activation state of Ras
Activation of the Ras signaling pathway promotes the growth of malignant human glioblastoma multiforme (GBM). Mutations in Ras are rare in GBM,...
