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Descending Neuron for Freezing Behavior in Drosophila melanogaster
Freezing is a defensive behavior characterized by immobility, which makes detection by predators difficult. Flies show freezing behavior in response...
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Primary neuron and astrocyte cultures from postnatal Callithrix jacchus: a non-human primate in vitro model for research in neuroscience, nervous system aging, and neurological diseases of aging
The ability to generate in vitro cultures of neuronal cells has been instrumental in advancing our understanding of the nervous system. Rodent models...
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Functional suppression of Ripk1 blocks the NF-κB signaling pathway and induces neuron autophagy after traumatic brain injury
Traumatic brain injury (TBI), known as intracranial injury, has been a serious threat to human health. Evidence exists indicating that autophagy and...
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Conversion of human urine-derived cells into neuron-like cells by small molecules
Neural cell transplantation is an effective way for treatment of neurological diseases. However, the absence of transplantable human neurons remains...
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Layer 4 pyramidal neuron dendritic bursting underlies a post-stimulus visual cortical alpha rhythm
Alpha rhythms (9–11 Hz) are a dominant feature of EEG recordings, particularly over occipital cortex on cessation of a visual stimulation. Little is...
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Mathematical Modeling of Calcium Oscillatory Patterns in a Neuron
AbstractCalcium oscillations are an imperative mode of signaling phenomenon. These oscillations are due to the active interactions taking place...
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Primary cilia promote the differentiation of human neurons through the WNT signaling pathway
BackgroundPrimary cilia emanate from most human cell types, including neurons. Cilia are important for communicating with the cell’s immediate...
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The Neuromotor Junction
The neuromuscular junction (NMJ) is a pivotal point of interest in skeletal muscle physiology. This chapter dives into the innovative research in the...
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Improvement of sensory neuron growth and survival via negatively regulating PTEN by miR-21-5p-contained small extracellular vesicles from skin precursor-derived Schwann cells
BackgroundPatients with peripheral nerve injury (PNI) often suffer from hypoxic ischemic impairments, in particular when combined with vascular...
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The inhibition of miR-17-5p promotes cortical neuron neurite growth via STAT3/GAP-43 pathway
Spinal cord injury (SCI) is a devastating disease associated with locomotor function impair. The limited regenerative capability of the neural axon...
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Glycolysis-derived alanine from glia fuels neuronal mitochondria for memory in Drosophila
Glucose is the primary source of energy for the brain; however, it remains controversial whether, upon neuronal activation, glucose is primarily used...
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Calpain system is altered in survival motor neuron-reduced cells from in vitro and in vivo spinal muscular atrophy models
Spinal muscular atrophy (SMA) is a severe neuromuscular disorder caused by loss of the survival motor neuron 1 ( SMN1 ) gene. SMA is characterized by...
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Mechanistic insights of neuronal calcium and IP3 signaling system regulating ATP release during ischemia in progression of Alzheimer’s disease
The mechanisms of calcium ([Ca 2+ ]) signaling in various human cells have been widely analyzed by scientists due to its crucial role in human organs...
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NeuronBridge: an intuitive web application for neuronal morphology search across large data sets
BackgroundNeuroscience research in Drosophila is benefiting from large-scale connectomics efforts using electron microscopy (EM) to reveal all the...
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Long noncoding RNA small nucleolar RNA host gene 5 facilitates neuropathic pain in spinal nerve injury by promoting SCN9A expression via CDK9
This study aims to explore the functions and mechanisms of long noncoding RNA small nucleolar RNA host gene 5 (SNHG5) in chronic constriction injury...
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BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets
BigNeuron is an open community bench-testing platform with the goal of setting open standards for accurate and fast automatic neuron tracing. We...
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Inflammation Modifies miR-21 Expression Within Neuronal Extracellular Vesicles to Regulate Remyelination Following Spinal Cord Injury
Cell‒cell communication following spinal cord injury (SCI) plays a key role in remyelination and neurological recovery. Although communication...
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Taurine ameliorates axonal damage in sciatic nerve of diabetic rats and high glucose exposed DRG neuron by PI3K/Akt/mTOR-dependent pathway
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes and axonopathy is its main pathological feature. Previous studies suggested...
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Necroptosis is dispensable for motor neuron degeneration in a mouse model of ALS
Motor neuron degeneration in amyotrophic lateral sclerosis (ALS) is proposed to occur by necroptosis, an inflammatory form of regulated cell death....
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Hippocampal neurons code individual episodic memories in humans
The hippocampus is an essential hub for episodic memory processing. However, how human hippocampal single neurons code multi-element associations...
