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Target Mimic and Short Tandem Target Mimic Technologies for Deciphering Functions of miRNAs in Plants
MicroRNAs (miRNAs) are central players in the regulation of gene expression at post-transcriptional level and are involved in numerous biological...
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Overview of miRNA biogenesis and applications in plants
Numerous types of small RNAs play an important role in sustainable agricultural plant productivity. The micro RNAs (miRNAs) are tiny, 20–24 nt...
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miR-34-5p, a novel molecular target against lepidopteran pests
The management of economically important lepidopteran pests has relied heavily on chemical and Bt-bio pesticides since 1940s, which has led to...
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miRNA in cardiac development and regeneration
Ischemic heart disease is one of the main causes of morbidity and mortality in the world. In adult mammalian hearts, most cardiomyocytes are...
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miRNA-195-5p/PSAT1 feedback loop in human triple-negative breast cancer cells
BackgroundSubstantial evidence suggests that non-coding RNAs, such as microRNAs (miRNAs), play a vital role in human cancer. Phosphoserine...
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MiRNA expression analysis during somatic embryogenesis in Coffea canephora
Somatic embryogenesis (SE) is a biological process by which somatic cells can be differentiated and undifferentiated by epigenetic reprograming....
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Cooperative miRNA-dependent PTEN regulation drives resistance to BTK inhibition in B-cell lymphoid malignancies
Aberrant microRNA (miR) expression plays an important role in pathogenesis of different types of cancers, including B-cell lymphoid malignancies and...
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New insights into circRNA and its mechanisms in angiogenesis regulation in ischemic stroke: a biomarker and therapeutic target
Ischemic stroke accounts for about 71% of strokes worldwide. Due to limited recommended therapeutics for ischemic stroke, more attention is focused...
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Deciphering the role of RNA structure in translation efficiency
BackgroundRNA secondary structure has broad impact on the fate of RNA metabolism. The reduced stability of secondary structures near the...
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Comprehensive machine-learning-based analysis of microRNA–target interactions reveals variable transferability of interaction rules across species
BackgroundMicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally via base-pairing with complementary...
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Genome Editing and miRNA-Based Approaches in Cereals under Abiotic Stress
The unpredictable climate change and alarming rise in the world’s population warrant technological advancements in crop breeding to achieve a...
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Overview of host miRNA properties and their association with epigenetics, long non-coding RNAs, and Xeno-infectious factors
MicroRNA-derived structures play impressive roles in various biological processes. So dysregulation of miRNAs can lead to different human diseases....
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Genome-wide identification of drought-responsive microRNAs and their target genes in Chinese jujube by deep sequencing
BackgroundMicroRNAs (miRNAs) are about 21 snucleotide (nt) long, non-coding RNAs that play an important role in plant abiotic stress responses....
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Expression and Purification of tRNA/ pre-miRNA-Based Recombinant Noncoding RNAs
Research on RNA function and therapeutic potential is dominated by the use of chemoengineered RNA mimics. Recent efforts have led to the...
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A novel miRNA-based classification model of risks and stages for clear cell renal cell carcinoma patients
BackgroundClear cell renal cell carcinoma (ccRCC) is the most common subtype of renal carcinoma and patients at advanced stage showed poor survival...
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The association between genetic variation rs2292832 and the processing efficiency of pre-mir-149 affects the risk of breast cancer
BackgroundmicroRNAs (miRNAs) play key roles in regulating cancer development, including breast cancer. Variation in miRNA genes can associate with...
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Integrative analysis of circRNA, miRNA, and mRNA profiles to reveal ceRNA regulation in chicken muscle development from the embryonic to post-hatching periods
BackgroundThe growth and development of skeletal muscle are regulated by protein-coding genes and non-coding RNA. Circular RNA (circRNA) is a type of...
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Transcriptome analysis reveals FABP5 as a key player in the development of chicken abdominal fat, regulated by miR-122-5p targeting
BackgroundThe development of abdominal fat and meat quality are closely related and can impact economic efficiency. In this study, we conducted...
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1, 25-(OH)2D3 protects against ER stress and miRNA dysregulation in Mus musculus neurons
BackgroundThe pathophysiology of neurodegenerative diseases (NDDs) is closely associated with cellular oxidative stress which can result in the...
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Identification and validation of miRNA reference genes in poplar under pathogen stress
Quantitative real time polymerase chain reaction (qRT-PCR) is a common method to analyze gene expression. Due to differences in RNA quantity,...
