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Cooperation of chromatin remodeling SWI/SNF complex and pioneer factor AP-1 shapes 3D enhancer landscapes
The mechanism controlling the dynamic targeting of SWI/SNF has long been postulated to be coordinated by transcription factors (TFs), yet...
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Blockade of the ADAM8-Fra-1 complex attenuates neuroinflammation by suppressing the Map3k4/MAPKs axis after spinal cord injury
BackgroundMechanical spinal cord injury (SCI) is a deteriorative neurological disorder, causing secondary neuroinflammation and neuropathy. ADAM8 is...
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Subtractive sequence analysis aided druggable targets mining in Burkholderia cepacia complex and finding inhibitors through bioinformatics approach
Burkholderia cepacia complex (BCC) is a group of gram-negative bacteria composed of at least 20 different species that cause diseases in plants,...
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An across breed, diet and tissue analysis reveals the transcription factor NR1H3 as a key mediator of residual feed intake in beef cattle
BackgroundProvision of feed is a major determinant of overall profitability in beef production systems, accounting for up to 75% of the variable...
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Retinoschisin and novel Na/K-ATPase interaction partners Kv2.1 and Kv8.2 define a growing protein complex at the inner segments of mammalian photoreceptors
The RS1 gene on Xp 22.13 encodes retinoschisin which is known to directly interact with the retinal Na/K-ATPase at the photoreceptor inner segments....
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The LINC Complex Assists the Nuclear Import of Mechanosensitive Transcriptional Regulators
Mechanical forces play pivotal roles in directing cell functions and fate. To elicit gene expression, either intrinsic or extrinsic mechanical...
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SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis
SARS-CoV-2 infection causes COVID-19, a severe acute respiratory disease associated with cardiovascular complications including long-term outcomes....
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Med23 supports angiogenesis and maintains vascular integrity through negative regulation of angiopoietin2 expression
The mammalian Mediator complex consists of over 30 subunits and functions as a transcriptional hub integrating signaling for tissue-specific gene...
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Laccase-Mediator Systems as a Tool for the Development of Antistatic/Anticorrosion Protective Coatings Based on Conducting Polyaniline
AbstractTemplate polymerization of aniline was performed using a laccase-mediator system. The high redox-potential laccase from the basidiomycete...
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Exploring the Composition and Catalytic Specificity of Sorghum Histone Acetyltransferase Complexes
Histone acetylation plays important roles in gene regulation and is catalyzed by histone acetyltransferases (HATs). The performance of histone...
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Refeeding-associated AMPKγ1 complex activity is a hallmark of health and longevity
Late-life-initiated dietary interventions show limited efficacy in extending longevity or mitigating frailty, yet the underlying causes remain...
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MED12 is overexpressed in glioblastoma patients and serves as an oncogene by targeting the VDR/BCL6/p53 axis
Glioblastoma is the most life-threatening tumor of the central nervous system. Despite recent therapeutic advancements, maximum survival of...
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Elovanoid-N34 modulates TXNRD1 key in protection against oxidative stress-related diseases
The thioredoxin (TXN) system is an NADPH + H + /FAD redox-triggered effector that sustains homeostasis, bioenergetics, detoxifying drug networks, and...
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The Fork Protection Complex: A Regulatory Hub at the Head of the Replisome
As well as accurately duplicating DNA, the eukaryotic replisome performs a variety of other crucial tasks to maintain genomic stability. For example,...
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Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction
Human naive pluripotent stem cells have unrestricted lineage potential. Underpinning this property, naive cells are thought to lack chromatin-based...
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Ccr4-Not as a mediator of environmental signaling: a jack of all trades and master of all
The cellular response to environmental exposures, such as nutrient shifts and various forms of stress, requires the integration of the signaling...
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DDX5 inhibits type I IFN production by promoting degradation of TBK1 and disrupting formation of TBK1 − TRAF3 complex
DExD/H-box helicase (DDX) 5 belongs to the DExD/H-box helicase family. DDX family members play differential roles in the regulation of innate...
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Indirect plant-mediated interactions between heterospecific parasitoids that develop in different caterpillar species
Parasitoids induce physiological changes in their herbivorous hosts that affect how plants respond to herbivory. The signature of parasitoids on...
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Lipid metabolism and ageing in Caenorhabditis elegans: a complex interplay
Life expectancy in Western countries is increasing, with concomitant rise in ageing-related pathologies, including Parkinson’s and Alzheimer’s...
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Pepper previously infested by MED facilitates settling and oviposition by MEAM1 of the Bemisia tabaci species complex
MEAM1 (Middle East-Asia Minor 1) and MED (Mediterranean), two cryptic species of the Bemisia tabaci species complex, are highly destructive...
