Search
Search Results
-
Transcriptomic analysis of lung development in wildtype and CFTR−/− sheep suggests an early inflammatory signature in the CF distal lung
The precise molecular events initiating human lung disease are often poorly characterized. Investigating prenatal events that may underlie lung...
-
Applications of lung cancer organoids in precision medicine: from bench to bedside
As the leading cause of cancer-related mortality, lung cancer continues to pose a menacing threat to human health worldwide. Lung cancer treatment...
-
The microRNA-1278/SHP-1/STAT3 pathway is involved in airway smooth muscle cell proliferation in a model of severe asthma both intracellularly and extracellularly
This study investigated the regulatory effects of microRNA-1278 (miR-1278) on airway inflammation, airway reconstruction, and the proliferation and...
-
Polymicrobial Biofilms in Cystic Fibrosis Lung Infections: Effects on Antimicrobial Susceptibility
Chronic lung infection is the main cause of morbidity and mortality in people with cystic fibrosis (CF). For many years, it was thought that...
-
Metformin regulates the effects of IR and IGF-1R methylation on mast cell activation and airway reactivity in diabetic rats with asthma through miR-152-3p/DNMT1 axis
Background/aimMetformin is a drug for treating type 2 diabetes mellitus (T2DM). Recently, metformin has been shown to reduce the risks of...
-
Metagenomic sequencing reveals swine lung microbial communities and metagenome-assembled genomes associated with lung lesions—a pilot study
Low microbial biomass in the lungs, high host-DNA contamination and sampling difficulty limit the study on lung microbiome. Therefore, little is...
-
Increased susceptibility of cystic fibrosis airway epithelial cells to ferroptosis
BackgroundDefective chloride transport in airway epithelial cells (AECs) and the associated lung disease are the main causes of morbidity and early...
-
Abnormal respiratory progenitors in fibrotic lung injury
Recent advances in single-cell RNA sequencing (scRNA-seq) and epithelium lineage labeling have yielded identification of multiple abnormal epithelial...
-
Challenges in Understanding the Lung Microbiota
The human lung has been less explored from the microbiological point of view because of the low concentration of microorganisms in this area,...
-
Porcine lung tissue slices: a culture model for PRCV infection and innate immune response investigations
Respiratory coronaviruses (RCoVs) significantly threaten human health, necessitating the development of an ex vivo respiratory culture system for...
-
Hypoxic hUCMSC-derived extracellular vesicles attenuate allergic airway inflammation and airway remodeling in chronic asthma mice
BackgroundAs one of the main functional forms of mesenchymal stem cells (MSCs), MSC-derived extracellular vesicles (MSC-EVs) have shown an...
-
A single-cell atlas of lung homeostasis reveals dynamic changes during development and aging
Aging is a global challenge, marked in the lungs by function decline and structural disorders, which affects the health of the elderly population. To...
-
Modeling of the brain-lung axis using organoids in traumatic brain injury: an updated review
Clinical outcome after traumatic brain injury (TBI) is closely associated conditions of other organs, especially lungs as well as degree of brain...
-
High D-glucose levels induce ACE2 expression via GLUT1 in human airway epithelial cell line Calu-3
BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters the host cell by binding to angiotensin-converting enzyme 2 (ACE2)...
-
SCNN1B regulates the proliferation, migration, and collagen deposition of human lung fibroblasts
The aim of this study was to investigate the role of amiloride-sensitive sodium channel protein 1B (SCNN1B) on the proliferation and migration of...
-
Prevention of severe lung immunopathology associated with influenza infection through adeno-associated virus vector administration
BackgroundInfluenza A viruses (IAVs) have long posed a threat to humans, occasionally causing significant morbidity and mortality. The initial immune...
-
Lung Organoid: Innovative Technology for Respiratory Disease Modelling
Introduction: The lungs are a complex organ with various cell types. Many factors can contribute to the damage of the lung epithelial cells,...
-
Remodeling and Restraining Lung Tissue Damage Through the Regulation of Respiratory Immune Responses
Tissue damage caused by various stimuli under certain conditions, such as biological and environmental cues, can actively induce systemic and/or...
-
A new perspective on gut-lung axis affected through resident microbiome and their implications on immune response in respiratory diseases
The highly diverse microbial ecosystem of the human body colonizes the gastrointestinal tract has a profound impact on the host’s immune, metabolic,...
-
Ultrashort wave diathermy inhibits pulmonary inflammation in mice with acute lung injury in a HSP70 independent way: a pilot study
BackgroundAcute lung injury (ALI) is a clinical syndrome characterized by pulmonary inflammation. Ultrashort wave diathermy (USWD) has been shown to...
