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Calcium signatures and signal transduction schemes during microbe interactions in Arabidopsis thaliana
Calcium (Ca 2+ ) is considered as crucial second messenger in all living organisms. Ca 2+ signaling regulates a diverse array of different biological...
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Genome-wide analysis of the apple CaCA superfamily reveals that MdCAX proteins are involved in the abiotic stress response as calcium transporters
BackgroundCalcium (Ca 2+ ) plays an important role in plant growth and development, and the maintenance of calcium homeostasis is necessary for the...
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Ca2+ mobilization-dependent reduction of the endoplasmic reticulum lumen is due to influx of cytosolic glutathione
BackgroundThe lumen of the endoplasmic reticulum (ER) acts as a cellular Ca 2+ store and a site for oxidative protein folding, which is controlled by...
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Calcium signaling modulates the dynamics of cilia and flagella
To adapt to changing environments cells must signal and signaling requires messengers whose concentration varies with time in space. We here consider...
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Fluorescence-Based Assay for TRPV1 Channels
The transient receptor potential vanilloid 1 ion channel (TRPV1) is a ligand-gated nonselective calcium-permeant cation channel involved in the...
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Calcium Signaling in Plants Under Drought
Environmental stresses are among the most important threats for food security since it adversely affects agricultural productivity. Among them,...
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Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats
The common pathogenesis of Alzheimer’s disease (AD) and Parkinson’s disease (PD) has been supported by biochemical, genetic and molecular evidence....
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Advances in molecular interactions between rice and insect herbivores
To adapt to each other, plants and insect herbivores have developed sophisticated molecular interactions. Here, we summarize current knowledge about...
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The Architecture and Properties of the Pollen Tube Cell Wall
The pollen tube wall differs in both structure and function from walls of vegetative plant cells. Cellulose represents only a small portion of the...
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Upregulation of genes encoding plastidic isoforms of antioxidant enzymes and osmolyte synthesis impart tissue tolerance to salinity stress in bread wheat
Wheat genotype Kharchia is a donor for salt tolerance in wheat breeding programs worldwide; however, the tolerance mechanism in Kharchia is yet to be...
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Community Organization and Metagenomics of Bacterial Assemblages Across Local Scale pH Gradients in Northern Forest Soils
Soil pH has shown to predict bacterial diversity, but mechanisms are still poorly understood. To investigate how bacteria distribute themselves as a...
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Co-chaperones of the Human Endoplasmic Reticulum: An Update
In mammalian cells, the rough endoplasmic reticulum (ER) plays central roles in the biogenesis of extracellular plus organellar proteins and in...
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Dissecting cell membrane tension dynamics and its effect on Piezo1-mediated cellular mechanosensitivity using force-controlled nanopipettes
The dynamics of cellular membrane tension and its role in mechanosensing, which is the ability of cells to respond to physical stimuli, remain...
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Calcium mediated functional interplay between myocardial cells upon laser-induced single-cell injury: an in vitro study of cardiac cell death signaling mechanisms
BackgroundThe electromechanical function of myocardial tissue depends on the intercellular communication between cardiomyocytes (CMs) as well as...
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Research Progress on TRPA1 in Diseases
For a long time, the physiological activity of TRP ion channels and the response to various stimuli have been the focus of attention, and the...
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Transient Receptor Potential Ankyrin 1 Contributes to Lysophosphatidylcholine-Induced Intracellular Calcium Regulation and THP-1-Derived Macrophage Activation
AbstractLysophosphatidylcholine (LPC) is a major atherogenic lipid that stimulates an increase in mitochondrial reactive oxygen species (mtROS) and...
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Deciphering the role of mechanosensitive channels in plant root biology: perception, signaling, and adaptive responses
Main conclusionMechanosensitive channels are integral membrane proteins that rapidly translate extrinsic or intrinsic mechanical tensions into...
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Activation of Piezo1 downregulates renin in juxtaglomerular cells and contributes to blood pressure homeostasis
BackgroundThe synthesis and secretion of renin in juxtaglomerular (JG) cells are closely regulated by the blood pressure. To date, however, the...
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Activation of the glutamatergic cingulate cortical-cortical connection facilitates pain in adult mice
The brain consists of the left and right cerebral hemispheres and both are connected by callosal projections. Less is known about the basic mechanism...
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Inhibition of TRPV4 remodels single cell polarity and suppresses the metastasis of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a malignant tumor, frequently causing both intrahepatic and extrahepatic metastases. The overall prognosis of...
