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Anthocyanins: Quantification by Tandem Mass Spectrometry
Mass spectrometry is a high throughput technique widely used for metabolic fingerprinting of plant material. Among the diverse plant metabolites,...
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Characterization and Purification of Biosurfactants
Biosurfactants are the leading environmentally friendly sustainable microbial product. They are well known due to their high selectivity and specific...
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Capsaicin: Its Sources, Isolation, Quantitative Analysis and Applications
Capsaicin is a phenolic compound found in hot peppers and responsible for the characteristic pungent taste and burning sensation. The genus Capsicum...
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Chemical and Toxicological Studies of the Toxic Freshwater Cyanobacterium: Microcystis aeruginosa
Globally, cyanobacterial hazardous algal blooms are becoming more frequent and intense due to eutrophication and climate change. Microcystis...
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Non-targeted Lipidomics Using a Robust and Reproducible Lipid Separation Using UPLC with Charged Surface Hybrid Technology and High-Resolution Mass Spectrometry
Lipids play an important role in the energy storage, cellular signaling, and pathophysiology of diseases such as cancer, neurodegenerative diseases,...
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Blood-based liquid biopsy: insights into early detection, prediction, and treatment monitoring of bladder cancer
Bladder cancer (BC) is a clinical challenge worldwide with late clinical presentation, poor prognosis, and low survival rates. Traditional cystoscopy...
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Advances in Tools and Techniques to Quantify Melatonin in Plants and Foodstuff
As an ancient pleiotropic molecule, melatonin (N-acetyl-5-methoxytryptamine) regulates numerous cellular, physiological, biochemical, and molecular...
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Lipid Analysis by Gas Chromatography and Gas Chromatography–Mass Spectrometry
Gas chromatography (GC) and gas chromatography–mass spectrometry (GC-MS) represent powerful tools for the quantitative and structural analysis of...
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Size-exclusion chromatography combined with DIA-MS enables deep proteome profiling of extracellular vesicles from melanoma plasma and serum
Extracellular vesicles (EVs) are important players in melanoma progression, but their use as clinical biomarkers has been limited by the difficulty...
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TLR3-mediated Astrocyte Responses in High and Normal Glucose Adaptation Differently Regulated by Metformin
Toll-like receptors 3 (TLR3) are innate immune receptors expressed on a wide range of cell types, including glial cells. Inflammatory responses...
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Natural Product Investigation in Lichens: Extraction and HPLC Analysis of Secondary Compounds in Mycobiont Cultures
Chromatography techniques facilitate separation, purification, and identification of secondary compounds (natural products) in lichens and their...
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Analysis and Annotation of Phospholipids by Mass Spectrometry-Based Metabolomics
Phospholipids are essential components of membrane lipid bilayers and serve as precursors of multiple signaling molecules, so alterations in their...
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Nanosensor Devices on the Detection of Cyanotoxin
Cyanotoxins are toxic substances produced by harmful cyanobacterial algal bloom. These harmful algal blooms pose detrimental effects to animals and...
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High-Throughput Phospholipidomics of Candida Cells: From Sample Preparation to Data Analysis
Laboratory identification of Candida species is often complicated by overlap** features. Species specificity is critical to the appropriate use of...
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Nontargeted lipidomics in nesting females of three sea turtle species in Florida by ultra-high-pressure liquid chromatography–high-resolution tandem mass spectrometry (UHPLC–HRMS/MS) reveals distinct species-specific lipid signatures
In recent years, the utility of lipidomics has been recognized in environmental toxicology and biomonitoring efforts due to the ubiquitous nature and...
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Peptide Synthesis
Peptide synthesis is characterized by forming a substituted amide linkage between two amino acids. The first successful attempt to synthetically link...
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Transcriptomic and metabolomic dissection of skeletal muscle of crossbred Chongming white goats with different meat production performance
BackgroundThe transcriptome and metabolome dissection of the skeletal muscle of high- and low- growing individuals from a crossbred population of the...
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HPLC-MS Characterization of Tissue-Derived Heparan Sulfate and Chondroitin Sulfate
Glycosaminoglycans (GAGs) are built up of repeating disaccharide units resulting in long, linear polysaccharide chains. In most classes of GAGs,...
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From Swab to Spectrum: A Comprehensive Guide to Optimizing Simple Gas Chromatography-Mass Spectrometry Analysis of Vertebrate Odorants
Vertebrate odorants are essential to communication, but their complex chemical compositions are challenging to study. Here, we optimize a workflow...
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An automated liquid jet for fluorescence dosimetry and microsecond radiolytic labeling of proteins
X-ray radiolytic labeling uses broadband X-rays for in situ hydroxyl radical labeling to map protein interactions and conformation. High flux density...
