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Regime shifts in rocky intertidal communities associated with a marine heatwave and disease outbreak
Long-term, large-scale experimental studies provide critical information about how global change influences communities. When environmental changes...
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Transitions from Centrosomal to Non-centrosomal Microtubule Organization During Cellular Polarization
Cellular polarization involves significant remodeling and decentralization of the nucleus-associated centrosome to focal points at the apical and...
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Genome-Scale CRISPR Screening for Regulators of Cell Fate Transitions
Knockout CRISPR screening enables the unbiased discovery of genes with a functional role in almost any cellular or molecular process of interest. The...
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Shifts in soil microbial stoichiometry and metabolic quotient provide evidence for a critical tip** point at 1% soil organic carbon in an agricultural post-mining chronosequence
Soil microbial C:N:P stoichiometry and microbial maintenance respiration (i.e. metabolic quotient, qCO 2 ) were monitored along a nutrient gradient in...
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PC3T: a signature-driven predictor of chemical compounds for cellular transition
Cellular transitions hold great promise in translational medicine research. However, therapeutic applications are limited by the low efficiency and...
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Maturation of the digestive system of Downs herring larvae (Clupea harengus, Linnaeus, 1758): identification of critical periods through ontogeny
Digestive system functionality is a key process linked to larval recruitment and survival. However, little is known about organ development and...
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From stationary to directional transition: a case study in Doñana
ContextDoñana’s landscape is a mosaic of different types of transitions at different spatial and temporal scales. Among them, stationary transitions...
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Microclimate feedbacks sustain power law clustering of encroaching coastal woody vegetation
The spatial pattern of vegetation patchiness may follow universal characteristic rules when the system is close to critical transitions between...
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Multidimensional specialization and generalization are pervasive in soil prokaryotes
Habitat specialization underpins biological processes from species distributions to speciation. However, organisms are often described as specialists...
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Metabolic plasticity enables lifestyle transitions of Porphyromonas gingivalis
Our understanding of how the oral anaerobe Porphyromonas gingivalis can persist below the gum line, induce ecological changes, and promote...
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Critical factors influencing in vitro propagation and modulation of important secondary metabolites in Withania somnifera (L.) dunal
Withania somnifera (L.) Dunal is a valuable medicinal plant in the Solanaceae family. It is commonly known as Ashwagandha and is widely distributed...
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Single-cell transcriptomes reveal a molecular link between diabetic kidney and retinal lesions
The occurrence of diabetic nephropathy (DN) and diabetic retinopathy (DR) are closely associated in patients with diabetes. However, the cellular and...
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Structural basis for abscisic acid efflux mediated by ABCG25 in Arabidopsis thaliana
Abscisic acid (ABA) is a phytohormone essential to the regulation of numerous aspects of plant growth and development. The cellular level of ABA is...
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Facultative Transitions Have Trouble Committing, But Stable Life Cycles Predict Salamander Genome Size Evolution
Facultative traits can provide phenotypic lability in dynamic environments, but it is unclear how weaving between disparate habitats impacts...
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Critical speeding up as an early warning signal of stochastic regime shifts
The use of critical slowing down as an early warning indicator for regime switching in observations from noisy dynamical systems and models has been...
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Single-molecule visualization of human A2A adenosine receptor activation by a G protein and constitutively activating mutations
Mutations that constitutively activate G protein-coupled receptors (GPCRs), known as constitutively activating mutations (CAMs), modify cell...
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Decoding the principle of cell-fate determination for its reverse control
Understanding and manipulating cell fate determination is pivotal in biology. Cell fate is determined by intricate and nonlinear interactions among...
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Evolution of sex determination in crustaceans
Sex determination (SD) involves mechanisms that determine whether an individual will develop into a male, female, or in rare cases, hermaphrodite....
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Excited-state observation of active K-Ras reveals differential structural dynamics of wild-type versus oncogenic G12D and G12C mutants
Despite the prominent role of the K-Ras protein in many different types of human cancer, major gaps in atomic-level information severely limit our...
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Mitigating non-genetic resistance to checkpoint inhibition based on multiple states of immune exhaustion
Despite the revolutionary impact of immune checkpoint inhibition on cancer therapy, the lack of response in a subset of patients, as well as the...
