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Novel mutation in LRP5 gene cause rare osteosclerosis: cases studies and literature review
To study the effects of low-density lipoprotein receptor-related protein 5 ( LRP5 ) gene mutations on bone, and to open up our view of LRP5 and Wnt...
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Abnormal activation of the Wnt3a/β-catenin signaling pathway promotes the expression of T-box transcription factor 3(TBX3) and the epithelial-mesenchymal transition pathway to mediate the occurrence of adenomyosis
BackgroundT-box transcription factor 3(TBX3) is a transcription factor that can regulate cell proliferation, apoptosis, invasion, and migration in...
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Endothelial DR6 in blood-brain barrier malfunction in Alzheimer’s disease
The impairment of the blood-brain barrier (BBB) has been increasingly recognised as a critical element in the early pathogenesis of Alzheimer’s...
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DNER promotes epithelial–mesenchymal transition and prevents chemosensitivity through the Wnt/β-catenin pathway in breast cancer
Breast cancer (BC) is the most common malignant tumour in women worldwide, and one of the most common fatal tumours in women. Delta/Notch-like...
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Serum-derived extracellular vesicles mediate Smad4 expression through shuttling microRNA-27a in the progression of laryngeal squamous cell carcinoma
Serum-derived extracellular vesicles (EVs) containing non-coding RNAs have been indicated to serve as diagnostic and prognostic biomarkers for...
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A genome-wide CRISPR screen identifies BRD4 as a regulator of cardiomyocyte differentiation
Human induced pluripotent stem cell (hiPSC) to cardiomyocyte (CM) differentiation has reshaped approaches to studying cardiac development and...
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Effect of endostatin on Wnt pathway of stem-like cells in bladder cancer in tumor microenvironment
Wnt/β-catenin signaling pathway modulates miscellaneous biological events in cells including gene expression, cell growth, apoptosis, metabolism and...
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The Effect of Selenium on Endometrial Repair in Goats with Endometritis at High Cortisol Levels
Endometritis is a common postpartum disease of female animals that causes significant losses to the goat industry. High levels of cortisol induced by...
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JUNB affects hair follicle development and regeneration by promoting the proliferation of dermal papilla cells in goat
BackgroundThe process of hair follicle morphogenesis, development, and regeneration essentially depends on the interaction between skin epidermis and...
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PRMT2 promotes RCC tumorigenesis and metastasis via enhancing WNT5A transcriptional expression
Protein arginine methyltransferase 2 (PRMT2) is involved in several biological processes via histone methylation and transcriptional regulation....
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The truncated AXIN1 isoform promotes hepatocellular carcinoma metastasis through SRSF9-mediated exon 9 skip**
Axis inhibitor protein 1 (AXIN1) is a protein recognized for inhibiting tumor growth and is commonly involved in cancer development. In this study,...
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Absence of the primary cilia formation gene Talpid3 impairs muscle stem cell function
Skeletal muscle stem cells (MuSC) are crucial for tissue homoeostasis and repair after injury. Following activation, they proliferate to generate...
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Wnt10b knockdown regulates the relative balance of adipose tissue-resident T cells and inhibits white fat deposition
BackgroundWnt10b is one of critical Wnt family members that being involved in networks controlling stemness, pluripotency and cell fate decisions....
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Dickkopf1 induces enteric neurogenesis and gliogenesis in vitro if apoptosis is evaded
Neurogenesis in the postnatal enteric nervous system (ENS) is controversially discussed. Yet, deciphering the regenerative potential of the ENS is...
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Linking the YTH domain to cancer: the importance of YTH family proteins in epigenetics
N6-methyladenosine (m6A), the most prevalent and reversible modification of mRNA in mammalian cells, has recently been extensively studied in...
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Gene Expression in Bronchial Epithelial Cell Responses to Vanadium Exposure
Vanadium exposure has the adverse effect on lung function in human, whereas the detailed mechanisms of vanadium exposure-induced pulmonary toxicity...
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PRDM14 extinction enables the initiation of trophoblast stem cell formation
Trophoblast stem cells (TSCs) can be chemically converted from embryonic stem cells (ESCs) in vitro. Although several transcription factors (TFs)...
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Genome-wide identification and expression analysis of the GSK gene family in wheat (Triticum aestivum L.)
BackgroundPlant glycogen synthase kinase 3/shaggy kinase (GSK3) proteins contain the conserved kinase domain and play a pivotal role in the...
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The compact genome of the sponge Oopsacas minuta (Hexactinellida) is lacking key metazoan core genes
BackgroundExplaining the emergence of the hallmarks of bilaterians is a central focus of evolutionary developmental biology—evodevo—and evolutionary...
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CK2α-mediated phosphorylation of GRP94 facilitates the metastatic cascade in triple-negative breast cancer
Distant metastasis is a significant hallmark affecting to the high death rate of patients with triple-negative breast cancer (TNBC). Thus, it is...
