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A small natural molecule CADPE kills residual colorectal cancer cells by inhibiting key transcription factors and translation initiation factors
Residual disease is the major cause for colorectal cancer (CRC) relapse. Herein, we explore whether and how a natural molecule CADPE killed...
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Translation: Übersetzung des Gens ins Phän
Die Übersetzung der Nucleotidsequenz der DNA in die Aminosäuresequenz der Proteine beruht auf dem genetischen Code. Die Dolmetschermoleküle, welche...
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Initiation and progression of α-synuclein pathology in Parkinson’s disease
α-Synuclein aggregation is a critical molecular process that underpins the pathogenesis of Parkinson’s disease. Aggregates may originate at synaptic...
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Reconstitution of Mammalian Mitochondrial Translation System Capable of Long Polypeptide Synthesis
Mammalian mitochondria have their own dedicated protein synthesis system, which produces 13 essential subunits of the oxidative phosphorylation...
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GhWER controls fiber initiation and early elongation by regulating ethylene signaling pathway in cotton (Gossypium hirsutum)
Cotton fibers are specialized single-cell trichomes derived from epidermal cells, similar to root hairs and trichomes in Arabidopsis . While the...
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Global Assessment of Protein Translation in Mammalian Cells Using Polysome Fractionation
A character of active protein translation is formation of multiple ribosomes, or polysomes, on translating mRNAs. Polysome intensity reflects global...
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Selective footprinting of 40S and 80S ribosome subpopulations (Sel-TCP-seq) to study translation and its control
Multiple aspects of mRNA translation are subject to regulation. Here we present a ribosome footprinting protocol to determine the location and...
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The eukaryotic initiation factor 5A (eIF5A1), the molecule, mechanisms and recent insights into the pathophysiological roles
Since the demonstration of its involvement in cell proliferation, the eukaryotic initiation factor 5A (eIF5A) has been studied principally in...
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METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis
METTL3 encodes the predominant catalytic enzyme to promote m 6 A methylation in nucleus. Recently, accumulating evidence has shown the expression of...
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Measuring Repeat-Associated Non-AUG (RAN) Translation
Expansions of short nucleotide repeats account for more than 50 neurological or neuromuscular diseases. Many repeat expansion-containing RNAs can...
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Selective recruitment of stress-responsive mRNAs to ribosomes for translation by acetylated protein S1 during nutrient stress in Escherichia coli
The chemical modification of ribosomes plays an important regulatory role in cellular translation adaptation in response to environmental stresses....
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Gemin5-dependent RNA association with polysomes enables selective translation of ribosomal and histone mRNAs
Selective translation allows to orchestrate the expression of specific proteins in response to different signals through the concerted action of...
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Atlas of mRNA translation and decay for bacteria
Regulation of messenger RNA stability is pivotal for programmed gene expression in bacteria and is achieved by a myriad of molecular mechanisms. By...
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Development of PVY resistance in tomato by knockout of host eukaryotic initiation factors by CRISPR-Cas9
Tomato ( Solanum lycopersicum ) is a valuable crop worldwide and is widely infected with the potyvirus potato virus Y (PVY), which causes serious yield...
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CircPrimer 2.0: a software for annotating circRNAs and predicting translation potential of circRNAs
BackgroundSome circular RNAs (circRNAs) can be translated into functional peptides by small open reading frames (ORFs) in a cap-independent manner....
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Defense responses and symbiotic functional initiation in trifoliate orange‒arbuscular mycorrhizal fungi interaction
Arbuscular mycorrhizal fungi (AMF) trigger beneficial effects on their hosts, but it is unknown how plants modulate their defense responses during...
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Human Mitoribosome Profiling: A Re-engineered Approach Tailored to Study Mitochondrial Translation
To understand the human mitochondrial translation process, tools are required to dissect this system at a global scale. The mechanisms and regulation...
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ORFik: a comprehensive R toolkit for the analysis of translation
BackgroundWith the rapid growth in the use of high-throughput methods for characterizing translation and the continued expansion of multi-omics,...
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Host adaptive mutations in the 2009 H1N1 pandemic influenza A virus PA gene regulate translation efficiency of viral mRNAs via GRSF1
Avian species are the major natural reservoir from which pandemic influenza A viruses can be introduced to humans. Avian influenza A virus genes,...
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DNA 5mC and RNA m6A modification successively facilitates the initiation and perpetuation stages of HSC activation in liver fibrosis progression
Hepatic stellate cells (HSC) are key effector cells in liver fibrosis. Upon stimulation, the quiescent HSC undergoes complex morphological and...
