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Scutellaria baicalensis Georgi: Projection of Root Metabolome on Hairy Root Culture
AbstractThe study characterizes flavonoid and phenylethanoid metabolites of Baikal skullcap ( Scutellaria baicalensis ). The roots of intact plants...
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Endosymbioses: Origin and Diversity of Photosynthetic Eukaryotes and Their General Genetic Exchange Modes
It was through endosymbiosis that an archaeal host incorporated a free-living proteobacterium.
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MSI2 promotes translation of multiple IRES-containing oncogenes and virus to induce self-renewal of tumor initiating stem-like cells
AbstractRNA-binding protein Musashi 2 (MSI2) is elevated in several cancers and is linked to poor prognosis. Here, we tested if MSI2 promotes MYC and...
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Critical thinking of Alzheimer’s transgenic mouse model: current research and future perspective
Transgenic models are useful tools for studying the pathogenesis of and drug development for Alzheimer’s Disease (AD). AD models are constructed...
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Limiting Dilution Tumor Initiation Assay: An In Vivo Approach for the Study of Cancer Stem Cells
Cancer stem cells (CSCs) are a small subpopulation of self-renewing cancer cells that are present within tumors. Calculating the frequency of...
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Polyesters of 14-Hydroxylated Taxoids Found for the First Time in Taxus canadensis Intact Plants
AbstractTaxane diterpenoids (taxoids) are found only in representatives of the Taxaceae family (different yew species); however, the unique structure...
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Immunity, rumen metagenomics, ruminal variables, and growth performance of calves fed milk with sage (Salvia officinalis) essential oil
The study aimed to determine the effect of sage ( Salvia officinalis ) essential oil (EO) to the drinking milk until the weaning stage of Holstein ...
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CMYC-initiated HNF1A-AS1 overexpression maintains the stemness of gastric cancer cells
Cancer stem cells (CSCs) are believed to be responsible for cancer metastasis and recurrence due to their self-renewal ability and resistance to...
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Safety assessment, whole genome sequence, and metabolome analysis of Streptococcus thermophilus CICC 20372 for bone cement fermentation
Bone is a kind of meat processing by-product with high nutritional value but low in calorie, which is a typical food in China and parts of East Asian...
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Cephalosporin translocation across enterobacterial OmpF and OmpC channels, a filter across the outer membrane
Gram-negative porins are the main entry for small hydrophilic molecules. We studied translocation of structurally related cephalosporins, ceftazidime...
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MIRTH: Metabolite Imputation via Rank-Transformation and Harmonization
Out of the thousands of metabolites in a given specimen, most metabolomics experiments measure only hundreds, with poor overlap across experimental...
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A novel nanobody as therapeutics target for EGFR-positive colorectal cancer therapy: exploring the effects of the nanobody on SW480 cells using proteomics approach
BackgroundThe epidermal growth factor receptor (EGFR) overexpression is found in metastatic colorectal cancer (mCRC). Targeted molecular therapies...
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Analysis of Root Response Mechanism of Quinoa Seedlings to Waterlogging Stress Based on Metabolome
Quinoa, a dicotyledonous annual herb belonging to the subfamily Amaranthaceae, has remarkable resistance to cold, drought, and barren conditions....
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Comparative proteomic analysis on chloroplast proteins provides new insights into the effects of low temperature in sugar beet
BackgroundLow temperature, which is one of the main environmental factors that limits geographical distribution and sucrose yield, is a common...
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Anthropogenic Transformation Disconnects a Lowland River From Contemporary Carbon Stores in Its Catchment
Rivers transport carbon from continents to oceans. Surprisingly, this carbon has often been found to be centuries old, not originating from...
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Integrative physiological and metabolic traits reveal the mechanisms of chamomile flowers in response to nicotine stress
BackgroundChamomile ( Matricaria recutita L.) is an important economic crop after tobacco ( Nicotiana tabacum L.) cultivation. The nicotine released...
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Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation
Oxidative phosphorylation (OXPHOS) consumes oxygen to produce ATP. However, the mechanism that balances OXPHOS activity and intracellular oxygen...
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In planta expression of human polyQ-expanded huntingtin fragment reveals mechanisms to prevent disease-related protein aggregation
In humans, aggregation of polyglutamine repeat (polyQ) proteins causes disorders such as Huntington’s disease. Although plants express hundreds of...
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Organ-specific extracellular matrix directs trans-differentiation of mesenchymal stem cells and formation of salivary gland-like organoids in vivo
BackgroundCurrent treatments for salivary gland (SG) hypofunction are palliative and do not address the underlying cause or progression of the...
