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Role of Magnesium in Type 2 Diabetes Mellitus
Magnesium (in its ionized and biologically active form, Mg 2+ ) is an essential trace element that participates in numerous physiologic processes....
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Critical role of lipid membranes in polarization and migration of cells: a biophysical view
Cell migration plays vital roles in many biologically relevant processes such as tissue morphogenesis and cancer metastasis, and it has fascinated...
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TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling
Toll-like receptor (TLR) 4 belongs to the TLR family of receptors inducing pro-inflammatory responses to invading pathogens. TLR4 is activated by...
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Potential contribution of intrinsic developmental stability toward body plan conservation
BackgroundDespite the morphological diversity of animals, their basic anatomical patterns—the body plans in each animal phylum—have remained highly...
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Polyvalent therapeutic vaccine for type 2 diabetes mellitus: Immunoinformatics approach to study co-stimulation of cytokines and GLUT1 receptors
BackgroundType 2 diabetes mellitus (T2DM) is a worldwide disease that have an impact on individuals of all ages causing micro and macro vascular...
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High-density lipoprotein regulates angiogenesis by affecting autophagy via miRNA-181a-5p
We previously demonstrated that normal high-density lipoprotein (nHDL) can promote angiogenesis, whereas HDL from patients with coronary artery...
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RIPK3 signaling and its role in regulated cell death and diseases
Receptor-interacting protein kinase 3 (RIPK3), a member of the receptor-interacting protein kinase (RIPK) family with serine/threonine protein kinase...
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Alpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle
Muscle contraction is driven by the molecular machinery of the sarcomere. As phosphorylation is a critical regulator of muscle function, the...
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Neurochemical Anatomy of the Mammalian Carotid Body
Carotid body (CB) glomus cells in most mammals, including humans, contain a broad diversity of classical neurotransmitters, neuropeptides and gaseous...
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Osteocalcin triggers Fas/FasL-mediated necroptosis in adipocytes via activation of p300
The uncarboxylated form of osteocalcin (GluOC) regulates glucose and lipid metabolism in mice. We previously showed that low-dose (≤10 ng/ml) GluOC...
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Omics-based biomarkers discovery for Alzheimer's disease
Alzheimer’s disease (AD) is the most common neurodegenerative disorders presenting with the pathological hallmarks of amyloid plaques and tau...
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Necroptosis and RhoA/ROCK pathways: molecular targets of Nesfatin-1 in cardioprotection against myocardial ischemia/reperfusion injury in a rat model
Nesfatin-1 as a new energy-regulating peptide has been known to display a pivotal role in modulation of cardiovascular functions and protection...
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‘Magnesium’-the master cation-as a drug—possibilities and evidences
Magnesium (Mg 2+ ) is the 2nd most abundant intracellular cation, which participates in various enzymatic reactions; there by regulating vital...
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Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution
Channel enzymes represent a class of ion channels with enzymatic activity directly or indirectly linked to their channel function. We investigated a...
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Validation of 46 loci associated with female fertility traits in cattle
BackgroundSubfertility is one challenge facing the dairy industry as the average Holstein heifer conception rate (HCR), the proportion of heifers...
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Single nuclei transcriptomics of muscle reveals intra-muscular cell dynamics linked to dystrophin loss and rescue
In Duchenne muscular dystrophy, dystrophin loss leads to chronic muscle damage, dysregulation of repair, fibro-fatty replacement, and weakness. We...
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ALPK2 acts as tumor promotor in development of bladder cancer through targeting DEPDC1A
Bladder cancer is one of the most common malignant tumors in the urinary system. The development and improvement of treatment efficiency require the...
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The extensive transgenerational transcriptomic effects of ocean acidification on the olfactory epithelium of a marine fish are associated with a better viral resistance
BackgroundProgressive CO 2 -induced ocean acidification (OA) impacts marine life in ways that are difficult to predict but are likely to become...
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The zebrafish cationic amino acid transporter/glycoprotein-associated family: sequence and spatiotemporal distribution during development of the transport system b0,+ (slc3a1/slc7a9)
System b 0,+ absorbs lysine, arginine, ornithine, and cystine, as well as some (large) neutral amino acids in the mammalian kidney and intestine. It...
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Cellular and molecular effects of hyperglycemia on ion channels in vascular smooth muscle
Diabetes affects millions of people worldwide. This devastating disease dramatically increases the risk of develo** cardiovascular disorders. A...
