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Multimeric Purinoceptor Detection by Bioluminescence Resonance Energy Transfer
Assays based on bioluminescence resonance energy transfer (BRET) provide a sensitive and simple method to study protein–protein interactions in live...
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ClpC2 protects mycobacteria against a natural antibiotic targeting ClpC1-dependent protein degradation
Mycobacterium tuberculosis Clp proteases are targeted by several antitubercular compounds, including cyclomarin A (CymA). CymA exerts its toxicity by...
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LSL1 controls cell death and grain production by stabilizing chloroplast in rice
Lesion mutants can be valuable tools to reveal the interactions between genetic factors and environmental signals and to improve grain production....
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A rice QTL GS3.1 regulates grain size through metabolic-flux distribution between flavonoid and lignin metabolons without affecting stress tolerance
Grain size is a key component trait of grain weight and yield. Numbers of quantitative trait loci (QTLs) have been identified in various...
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Characterization of Gene Regulatory Networks in Plants Using New Methods and Data Types
A major question in plant biology is to understand how plant growth, development, and environmental responses are controlled and coordinated by the...
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Citrus NIP5;1 aquaporin regulates cell membrane water permeability and alters PIPs plasma membrane localization
Key messageThe ER or donut-like structures localized aquaporin NIP5;1, which interacts with PIPs and alters their localization from plasma membrane...
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Plant HEM1 specifies a condensation domain to control immune gene translation
Translational reprogramming is a fundamental layer of immune regulation, but how such a global regulatory mechanism operates remains largely unknown....
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ER-misfolded proteins become sequestered with mitochondria and impair mitochondrial function
Proteostasis is a challenge for cellular organisms, as all known protein synthesis machineries are error-prone. Here we show by cell fractionation...
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Capture of regulatory factors via CRISPR–dCas9 for mechanistic analysis of fine-tuned SERRATE expression in Arabidopsis
SERRATE (SE) plays an important role in many biological processes and under biotic stress resistance. However, little about the control of SE has...
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Computational Methods and Deep Learning for Elucidating Protein Interaction Networks
Protein interactions play a critical role in all biological processes, but experimental identification of protein interactions is a time- and...
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AUR1 and its pals: orchestration of intracellular rhizobia infection in legume for nitrogen fixation
Key messageWe highlight the newly emerged regulatory role of a mitotic kinase AUR1, its activator, and its microtubule-associated proteins (MAPs) in...
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Epigenetic silencing of callose synthase by VIL1 promotes bud-growth transition in lily bulbs
In plants, restoring intercellular communication is required for cell activity in buds during the growth transition from slow to fast growth after...
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Phytochrome B triggers light-dependent chromatin remodelling through the PRC2-associated PHD finger protein VIL1
To compensate for a sessile nature, plants have developed sophisticated mechanisms to sense varying environmental conditions. Phytochromes (phys) are...
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LlWRKY39 is involved in thermotolerance by activating LlMBF1c and interacting with LlCaM3 in lily (Lilium longiflorum)
WRKY transcription factors (TFs) are of great importance in plant responses to different abiotic stresses. However, research on their roles in the...
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Mechano-sensitivity of β2-adrenoceptors enhances constitutive activation of cAMP generation that is inhibited by inverse agonists
The concept of agonist-independent signalling that can be attenuated by inverse agonists is a fundamental element of the cubic ternary complex model...
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The Pseudomonas syringae effector AvrPtoB targets abscisic acid signaling pathway to promote its virulence in Arabidopsis
Phytohormones play an essential role in plant immune responses. Many phytopathogens secret effector proteins to promote infection and plant hormone...
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Monitoring activities of receptor tyrosine kinases using a universal adapter in genetically encoded split TEV assays
Receptor tyrosine kinases (RTKs) play key roles in various aspects of cell biology, including cell-to-cell communication,...
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Multiplexed screens identify RAS paralogues HRAS and NRAS as suppressors of KRAS-driven lung cancer growth
Oncogenic KRAS mutations occur in approximately 30% of lung adenocarcinoma. Despite several decades of effort, oncogenic KRAS-driven lung cancer...
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Rice Carbohydrate-Binding Malectin-Like Protein, OsCBM1, Contributes to Drought-Stress Tolerance by Participating in NADPH Oxidase-Mediated ROS Production
Carbohydrate-binding malectin/malectin-like domain-containing proteins (CBMs) are a recently identified protein subfamily of lectins that...
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SWO1 modulates cell wall integrity under salt stress by interacting with importin ɑ in Arabidopsis
Maintenance of cell wall integrity is of great importance not only for plant growth and development, but also for the adaptation of plants to adverse...
