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3R-Refinement principles: elevating rodent well-being and research quality
This review article delves into the details of the 3R-Refinement principles as a vital framework for ethically sound rodent research laboratory. It...
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CHRM4/AKT/MYCN upregulates interferon alpha-17 in the tumor microenvironment to promote neuroendocrine differentiation of prostate cancer
Current treatment options for prostate cancer focus on targeting androgen receptor (AR) signaling. Inhibiting effects of AR may activate...
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Glycosylation editing: an innovative therapeutic opportunity in precision oncology
Cancer is still one of the most arduous challenges in the human society, even though humans have found many ways to try to conquer it. With our...
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From “self-differentiation” to organoids—the quest for the units of development
As proposed by Wilhelm Roux in 1885, the key goal of experimental embryology (“Entwicklungsmechanik”) was to elucidate whether organisms or their...
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Plant-litter-soil feedbacks in common grass species are slightly negative and only marginally modified by litter exposed to insect herbivory
PurposeInsect herbivory affects plant growth, nutrient and secondary metabolite concentrations and litter quality. Changes to litter quality due to...
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Capturing the start point of the virus–cell interaction with high-speed 3D single-virus tracking
The early stages of the virus–cell interaction have long evaded observation by existing microscopy methods due to the rapid diffusion of virions in...
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TOB1 attenuates IRF3-directed antiviral responses by recruiting HDAC8 to specifically suppress IFN-β expression
Interferon regulatory factor 3 (IRF3) is a key transcription factor required for the secretion of type I interferons (IFN-α/β) and initiation of...
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Ras suppression potentiates rear actomyosin contractility-driven cell polarization and migration
Ras has been extensively studied as a promoter of cell proliferation, whereas few studies have explored its role in migration. To investigate the...
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Distributed and dynamical communication: a mechanism for flexible cortico-cortical interactions and its functional roles in visual attention
Perceptual and cognitive processing relies on flexible communication among cortical areas; however, the underlying neural mechanism remains unclear....
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Discovering design principles for biological functionalities: Perspectives from systems biology
Network architecture plays a crucial role in governing the dynamics of any biological network. Further, network structures have been shown to remain...
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Commensal bacteria weaken the intestinal barrier by suppressing epithelial neuropilin-1 and Hedgehog signaling
The gut microbiota influences intestinal barrier integrity through mechanisms that are incompletely understood. Here we show that the commensal...
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Biochemical Mechanisms and Translational Relevance of Hippocampal Vulnerability to Distant Focal Brain Injury: The Price of Stress Response
Focal brain injuries (in particular, stroke and traumatic brain injury) induce with high probability the development of delayed (months, years)...
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Nutrition, Epigenetics, and Circadian Rhythms
Most organisms adapt to the 24-h cycle of the Earth’s rotation by anticipating the time of day through light–dark processes. The biological clock is...
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Nuclear respiratory factor 1 drives hepatocellular carcinoma progression by activating LPCAT1-ERK1/2-CREB axis
BackgroundNuclear respiratory factor 1 (NRF1) is a transcription factor that participates in several kinds of tumor, but its role in hepatocellular...
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From the eye to the wing: neural circuits for transforming optic flow into motor output in avian flight
Avian flight is guided by optic flow—the movement across the retina of images of surfaces and edges in the environment due to self-motion. In all...
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Musculoskeletal research in human space flight – unmet needs for the success of crewed deep space exploration
Based on the European Space Agency (ESA) Science in Space Environment (SciSpacE) community White Paper “Human Physiology – Musculoskeletal system”,...
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Integrating Multi-omics Approaches for Crop Resilience Under Changing Climatic Conditions
Globally agriculture systems are widely exposed to changing climatic conditions causing negative impacts on crop productivity. Different abiotic...
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Reproductive Neuroendocrinology of the Female South American Plains Vizcacha, Lagostomus maximus
Female plains vizcachas have several peculiar reproductive characteristics as a true reactivation of the hypothalamic–pituitary–ovarian axis during...
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The biofilm matrix: multitasking in a shared space
The biofilm matrix can be considered to be a shared space for the encased microbial cells, comprising a wide variety of extracellular polymeric...
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Mitochondrial Ca2+ uptake by the MCU facilitates pyramidal neuron excitability and metabolism during action potential firing
Neuronal activation is fundamental to information processing by the brain and requires mitochondrial energy metabolism. Mitochondrial Ca 2+ uptake by...
