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Genome-wide characterisation of HD-Zip transcription factors and functional analysis of PbHB24 during stone cell formation in Chinese white pear (Pyrus bretschneideri)
BackgroundThe homodomain-leucine zipper (HD-Zip) is a conserved transcription factor family unique to plants that regulate multiple developmental...
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Molecular insights into titin’s A-band
The thick filament-associated A-band region of titin is a highly repetitive component of the titin chain with important scaffolding properties that...
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Investigating the effects of a single ASPM variant (c.8508_8509) on brain architecture among siblings in a consanguineous Pakistani family
BackgroundAutosomal Recessive Primary Microcephaly (MCPH) is a rare, neurodevelopmental disorder associated with mild to severe mental retardation....
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Genomic insights into positive selection during barley domestication
BackgroundCultivated barley ( Hordeum vulgare ) is widely used in animal feed, beverages, and foods and has become a model crop for molecular...
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A mutation in CsDWF7 gene encoding a delta7 sterol C-5(6) desaturase leads to the phenotype of super compact in cucumber (Cucumis sativus L.)
Key messageA novel super compact mutant, scp-3 , was identified using map-based cloning in cucumber. The CsDWF7 gene encoding a delta7 sterol C-5(6)...
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Transcriptome-Wide Analysis Revealed the Influential Role of PbrMTP (Metal Tolerance Protein) in the Growth and Fruit Development of Chinese White Pear
Metal-tolerance proteins (MTPs) are divalent cation transporters and play fundamental roles in plant metal tolerance and ion homeostasis. Despite...
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Genome-wide identification and expression analysis of GRAS gene family in Eucalyptus grandis
BackgroundThe GRAS gene family is a class of plant-specific transcription factors with important roles in many biological processes, such as signal...
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Knockout of the Complex III subunit Uqcrh causes bioenergetic impairment and cardiac contractile dysfunction
Ubiquinol cytochrome c reductase hinge protein (UQCRH) is required for the electron transfer between cytochrome c 1 and c of the mitochondrial...
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Fine map** and characterization of the dominant gene SmFTSH10 conferring non-photosensitivity in eggplant (Solanum melongena L.)
Key message A candidate non photosensitive gene S m F TS H10 was identified by combining bulked segregant analysis and map‑based cloning. ...
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Multilayered control of exon acquisition permits the emergence of novel forms of regulatory control
BackgroundThe long introns of mammals are pools of evolutionary potential due to the multiplicity of sequences that permit the acquisition of novel...
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Molecular Verification of Trichophyton in the Brazilian URM Culture Collection
Trichophyton species cause dermatophytosis in humans, with a high, worldwide frequency of reports and important public health relevance. We evaluated...
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Spatial diversity of MHC class II DRB exon2 sequences in North African cape hares (Lepus capensis): positive selection and climatic adaptation signals
The genes of the major histocompatibility complex (MHC) are among the best candidates for studying adaptive variation driven often by...
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IPSC derived cardiac fibroblasts of DMD patients show compromised actin microfilaments, metabolic shift and pro-fibrotic phenotype
Duchenne muscular dystrophy (DMD) is a severe form of muscular dystrophy caused by mutations in the dystrophin gene. We characterized which isoforms...
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Identification of the early leaf senescence gene ELS3 in bread wheat (Triticum aestivum L.)
Main conclusionCharacterization of the early leaf senescence mutant els3 and identification of its causal gene ELS3 , which encodes an LRR-RLK...
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Genome-wide identification and expression analysis of the SOD gene family under biotic and abiotic stresses in sweet orange
Superoxide dismutase (SOD) protects plants from biotic and abiotic stress-induced reactive oxygen species toxicity and is extensively involved in...
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A mutation in CsGME encoding GDP-mannose 3,5-epimerase results in little and wrinkled leaf in cucumber
Key messageMap-based cloning revealed that a mutation in a highly conserved amino acid of the CsGME gene encoding GDP-mannose 3,5-epimerase, causes...
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De novo emergence, existence, and demise of a protein-coding gene in murids
BackgroundGenes, principal units of genetic information, vary in complexity and evolutionary history. Less-complex genes (e.g., long non-coding RNA...
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The origin and evolution of a two-component system of paralogous genes encoding the centromeric histone CENH3 in cereals
BackgroundThe cereal family Poaceae is one of the largest and most diverse angiosperm families. The central component of centromere specification and...
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Genome sequencing-based transcriptomic analysis reveals novel genes in Peucedanum praeruptorum
BackgroundPeucedanum praeruptorum Dunn, a traditional Chinese herbal medicine, contains coumarin and volatile oil components that have clinical...
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Variants of the SCD gene and their association with fatty acid composition in Awassi sheep
BackgroundGenetic factors affect the variability of fatty acid composition in ruminant products. Thus, this study aimed to investigate the...
