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Improving yield-related traits by editing the promoter of the heading date gene Ehd1 in rice
Key messageWe developed an efficient promoter editing method to create different weak Ehd1 alleles in elite japonica rice variety ZJ8 with slightly...
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Combination of ARE and HRE cis-Regulatory Elements Elevates the Activity of Tumor-Specific hTERT Promoter
AbstractTumor-specific promoters and cis -regulatory genetic elements are used for transcriptional control of therapeutic transgene expression in...
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High-yield BMP2 expression in rice cells via CRISPR and endogenous αAmy3 promoter
AbstractPlant cells serve as versatile platforms for the production of high-value recombinant proteins. This study explored the efficacy of utilizing...
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G-quadruplex structural dynamics at MAPK12 promoter dictates transcriptional switch to determine stemness in breast cancer
P38γ (MAPK12) is predominantly expressed in triple negative breast cancer cells (TNBC) and induces stem cell (CSC) expansion resulting in decreased...
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A natural variation in the promoter of GRA117 affects carbon assimilation in rice
Main conclusionGRA117 is crucial in the process of carbon assimilation in rice as it regulates the development of chloroplasts, which in turn...
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Characterization of transcriptional activities at a divergent promoter of the type VI secretion system in enterohemorrhagic Escherichia coli O157:H7
The type VI secretion system (T6SS) is a novel secretion system found in many Gram-negative bacteria that plays a role in bacterial competition,...
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Evaluation of cucumber UBL5 promoter as a tool for transgene expression and genome editing in plants
Transgene expression and genome editing can help improve cucumber varieties to better respond to climate change. This study aimed to evaluate the...
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HDAC3 deacetylates H3K27ac and H3K9ac on the TrkC promoter to exacerbate sevoflurane-induced neurotoxicity
BackgroundSevoflurane (Sev) is a widely used general anesthetic that can cause neurotoxicity. Histone acetylation is a vital epigenetic mechanism...
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Varicella-Zoster Virus ORF39 Transmembrane Protein Suppresses Interferon-Beta Promoter Activation by Interacting with STING
Varicella-Zoster virus (VZV) causes varicella in primary infection of children and zoster during reactivation in adults. Type I interferon (IFN)...
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Functional characterization of the pUceS8.3 promoter and its potential use for ectopic gene overexpression
Main ConclusionThe pUceS8.3 is a constitutive gene promoter with potential for ectopic and strong genes overexpression or active biomolecules in...
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PCGF6/MAX/KDM5D facilitates MAZ/CDK4 axis expression and pRCC progression by hypomethylation of the DNA promoter
Polycomb group RING finger protein 6 (PCGF6) plays an important role as a regulator of transcription in a variety of cellular processes, including...
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Promoter variations in a homeobox gene, BrLMI1, contribute to leaf lobe formation in Brassica rapa ssp. chinensis Makino
Key message BrLMI1 is a positive regulatory factor of leaf lobe formation in non-heading Chinese cabbage, and cis-regulatory variations lead to the...
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Cloning and characterization of the BZR1-2 promoter from Camellia sinensis and its responses to hormonal and abiotic stresses
Tea plant ( Camellia sinensis (L.) O. Kuntze) is an important woody economic crop that has been cultivated worldwide. Adversity stress acts as a...
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MG132 dramatically reduces SAA expression in chicken hepatocellular carcinoma cells at the transcript level independent of its endogenous promoter
BackgroundMG132, a proteasome inhibitor, is widely used to inhibit nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activity by...
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Generation of Atrial-Specific Construct Using Sarcolipin Promoter-Associated CRM4 Enhancer
Cardiac gene therapy has been hampered by off-target expression of gene of interest irrespective of variety of delivery methods. To overcome this...
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Supervised promoter recognition: a benchmark framework
MotivationDeep learning has become a prevalent method in identifying genomic regulatory sequences such as promoters. In a number of recent papers,...
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A regulatory element associated to NAFLD in the promoter of DIO1 controls LDL-C, HDL-C and triglycerides in hepatic cells
BackgroundGenome-wide association studies (GWAS) have identified genetic variants linked to fat metabolism and related traits, but rarely pinpoint...
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Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy
During formation of the transcription-competent open complex (RPo) by bacterial RNA polymerases (RNAPs), transient intermediates pile up before...
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Single nucleotide polymorphisms in the KRT82 promoter region modulate irregular thickening and patchiness in the dorsal skin of New Zealand rabbits
BackgroundWhile rabbits are used as models in skin irritation tests, the presence of irregular patches and thickening on the dorsal skin can affect...
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Evaluation of Connexin Hemichannel Activity In Vivo
Connexin hemichannels (Cx HCs) are hexameric structures at the cell plasma membrane, whose function as membrane transport proteins allows for the...