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Nicotinamide Riboside Promotes the Proliferation of Endogenous Neural Stem Cells to Repair Spinal Cord Injury
AbstractActivation of endogenous neural stem cells (NSC) is one of the most potential measures for neural repair after spinal cord injury. However,...
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Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis
The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo differentiation into osteoblasts. This differentiation process...
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Wdpcp regulates cellular proliferation and differentiation in the develo** limb via hedgehog signaling
BackgroundMice with a loss of function mutation in Wdpcp were described previously to display severe birth defects in the develo** heart, neural...
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Chromatin Remodeling During Leukemia Cell Proliferation and Differentiation
Chromatin dynamic during normal cell development and differentiation plays a pivotal role in cell functioning. Cellular processes such as DNA...
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The Signalling Effects of Photobiomodulation on Osteoblast Proliferation, Maturation and Differentiation: A Review
Proliferation of osteoblasts is essential for maturation and mineralization of bone matrix. Ossification, the natural phase of bone-forming and...
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Epithelium-derived SCUBE3 promotes polarized odontoblastic differentiation of dental mesenchymal stem cells and pulp regeneration
BackgroundSignal peptide-CUB-EGF domain-containing protein 3 (SCUBE3), a secreted multifunctional glycoprotein whose transcript expression is...
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The midgut epithelium of mosquitoes adjusts cell proliferation and endoreplication to respond to physiological challenges
BackgroundHematophagous mosquitoes transmit many pathogens that cause human diseases. Pathogen acquisition and transmission occur when female...
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Adipose-Derived Stromal Cells: Isolation, Expansion, and Differentiation
Adipose-derived stromal cells (ASC) are a promising alternative cell source to chondrocytes as well as to bone marrow-derived mesenchymal stromal...
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WNT5A regulates the proliferation, apoptosis and stemness of human stem Leydig cells via the β-catenin signaling pathway
Stem Leydig cells (SLCs) are essential for maintaining normal spermatogenesis as the significant component of testis microenvironment and gonadal...
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Rab37 Promotes Endothelial Differentiation and Accelerates ADSC-Mediated Diabetic Wound Healing through Regulating Secretion of Hsp90α and TIMP1
Accumulating evidence indicates that adipose tissue-derived mesenchymal stem cells (ADSCs) are an effective treatment for diabetic refractory wounds....
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BRD9 regulates normal human hematopoietic stem cell function and lineage differentiation
Bromodomain containing protein 9 (BRD9), a member of the non-canonical BRG1/BRM-associated factor (ncBAF) chromatin remodeling complex, has been...
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Effects of miR-125b-5p on Preadipocyte Proliferation and Differentiation in Chicken
Our previous studies have shown that miR-125b-5p was highly expressed and significantly upregulated during abdominal fat deposition in chickens....
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Enhancing Proliferation of Stem Cells from Human Exfoliated Deciduous Teeth (SHED) through hTERT Expression while Preserving Stemness and Multipotency
BackgroundStem cells from human exfoliated deciduous teeth (SHED) hold promise in regenerative medicine owing to their multipotent capabilities...
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All-Trans-Retinoid Acid (ATRA) Activates Notch Signaling to Inhibit Hind Limb Chondrogenesis by Suppressing Differentiation of Chondrogenic Cells
AbstractAll-trans retinoic acid (ATRA) plays an important role in chondrogenesis, this study is performed to dissect the correlated factors of...
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The Potential of miR-21 in Stem Cell Differentiation and its Application in Tissue Engineering and Regenerative Medicine
MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two important types of non-coding RNAs that are not translated into protein. These...
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miR-155-5p/Bmal1 Modulates the Senescence and Osteogenic Differentiation of Mouse BMSCs through the Hippo Signaling Pathway
BackgroundThe core clock gene brain and muscle ARNT like-1 (Bmal1) is involved in the regulation of bone tissue aging. However, current studies are...
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CDC42-mediated Wnt signaling facilitates odontogenic differentiation of DPCs during tooth root elongation
BackgroundCDC42 is a member of Rho GTPase family, acting as a molecular switch to regulate cytoskeleton organization and junction maturation of...
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FGF-independent MEK1/2 signalling in the develo** foetal testis is essential for male germline differentiation in mice
BackgroundDisrupted germline differentiation or compromised testis development can lead to subfertility or infertility and are strongly associated...
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Expansion of ventral foregut is linked to changes in the enhancer landscape for organ-specific differentiation
Cell proliferation is fundamental for almost all stages of development and differentiation that require an increase in cell number. Although cell...
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Enhancing cord blood stem cell-derived NK cell growth and differentiation through hyperosmosis
BackgroundNatural killer (NK) cells hold great promise in treating diverse hematopoietic and solid tumors. Despite their availability from peripheral...
