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Infradian Rhythms in Cerebrovascular Oxygenation and Blood Volume in Humans at Rest: A 5-Year Study
Background: All parameters of human physiology show chronobiological variability. While circadian (cycle length ~ 24 h) rhythms of the neuronal,...
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Cell segmentation in imaging-based spatial transcriptomics
Single-molecule spatial transcriptomics protocols based on in situ sequencing or multiplexed RNA fluorescent hybridization can reveal detailed tissue...
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Randomized boosting with multivariable base-learners for high-dimensional variable selection and prediction
BackgroundStatistical boosting is a computational approach to select and estimate interpretable prediction models for high-dimensional biomedical...
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A non-negative spike-and-slab lasso generalized linear stacking prediction modeling method for high-dimensional omics data
BackgroundHigh-dimensional omics data are increasingly utilized in clinical and public health research for disease risk prediction. Many previous...
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Genetic architecture of inter-specific and -generic grass hybrids by network analysis on multi-omics data
BackgroundUnderstanding the mechanisms underlining forage production and its biomass nutritive quality at the omics level is crucial for boosting the...
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Diverse environmental cues drive the size of reproductive aggregation in a rheophilic fish
BackgroundAnimal migrations are periodic and relatively predictable events, and their precise timing is essential to the reproductive success....
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Determinants of introduction success in alien mammals
Despite intensive research on colonization by non-native species, ecologists still cannot accurately predict their invasive abilities and likely...
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Genomic Selection
Genomic selection is a collection of statistical methods for predicting genomic values of individuals using molecular marker information. Genomic...
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A global phylogeny of butterflies reveals their evolutionary history, ancestral hosts and biogeographic origins
Butterflies are a diverse and charismatic insect group that are thought to have evolved with plants and dispersed throughout the world in response to...
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Measuring associations between the microbiota and repeated measures of continuous clinical variables using a lasso-penalized generalized linear mixed model
BackgroundHuman microbiome studies in clinical settings generally focus on distinguishing the microbiota in health from that in disease at a specific...
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Likely year-round presence of beaked whales in the Bay of Biscay
Beaked whales are cryptic and difficult to study species, often distributed in deep offshore waters and only briefly visible at the surface. A...
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Identification and Validation of Candidate Genes from Genome-Wide Association Studies
Exploiting the statistical associations coming out from a GWAS experiment to identify and validate candidate genesCandidate genes may be potentially...
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Functional principal component analysis for incomplete space–time data
Environmental signals, acquired, e.g., by remote sensing, often present large gaps of missing observations in space and time. In this work, we...
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Multiscale Modeling of Cross-Regulatory Transcript and Protein Influences
With the popularity of high-throughput transcriptomic techniques like RNAseq, models of gene regulatory networks have been important tools for...
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Statistical analysis of spatial expression patterns for spatially resolved transcriptomic studies
Identifying genes that display spatial expression patterns in spatially resolved transcriptomic studies is an important first step toward...
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A Selective Overview of Statistical Methods for Identification of the Treatment-Sensitive Subsets of Patients
Identification of a subset of patients who may benefit from or be sensitive to a specific type of treatment has become a very important research...
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Occupancy, Abundance, and Related Topics
Models for occupancy, where it is important to determine whether a particular species is present or not, have a long history. The literature is very...
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An overview of DNA methylation-derived trait score methods and applications
Microarray technology has been used to measure genome-wide DNA methylation in thousands of individuals. These studies typically test the associations...
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Evolutionary history of arbuscular mycorrhizal fungi and genomic signatures of obligate symbiosis
BackgroundThe colonization of land and the diversification of terrestrial plants is intimately linked to the evolutionary history of their symbiotic...
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Capture-Recapture: Frequentist Methods
Capture–recapture methods for both open and closed populations have developed extensively in recent years, especially with the development of...