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lncCPSET1 acts as a scaffold for MLL2/COMPASS to regulate Bmp4 and promote the formation of chicken primordial germ cells
Primordial germ cells (PGCs) are the ancestors of female and male germ cells. Recent studies have shown that long non-coding RNA (lncRNA) and histone...
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SIRT1 activation attenuates palmitate induced apoptosis in C2C12 muscle cells
BackgroundType 2 diabetes is characterized by insulin resistance, which manifests mainly in skeletal muscles. SIRT1 has been found to play a role in...
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Convergent gene losses and pseudogenizations in multiple lineages of stomachless fishes
The regressive evolution of independent lineages often results in convergent phenotypes. Several teleost groups display secondary loss of the...
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Aedes aegypti exhibits a distinctive mode of late ovarian development
BackgroundInsects live in almost every habitat on earth. To adapt to their diverse environments, insects have developed a myriad of different...
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Reprogramming Human Female Adipose Mesenchymal Stem Cells into Primordial Germ Cell-Like Cells
In the last two decades, considerable progress has been made in the derivation of mammalian germ cells from pluripotent stem cells such as Embryonic...
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Small molecule-mediated rapid maturation of human induced pluripotent stem cell-derived cardiomyocytes
BackgroundHuman induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iPSC-CMs) do not display all hallmarks of mature primary cardiomyocytes,...
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Mitochondrial transplantation protects against sepsis-induced myocardial dysfunction by modulating mitochondrial biogenesis and fission/fusion and inflammatory response
BackgroundSepsis-induced myocardial dysfunction is associated with worse clinical outcomes and high mortality, but no effective therapeutic...
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A dual Keap1 and p47phox inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis
Oxidative stress is a vital contributor to the development and progression of diabetes-accelerated atherosclerosis. Nuclear factor erythroid...
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Role of SIRT1 in Potentially Toxic Trace Elements (Lead, Fluoride, Aluminum and Cadmium) Associated Neurodevelopmental Toxicity
The formation of the central nervous system is a meticulously planned and intricate process. Any modification to this process has the potential to...
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Melatonin/nicotinamide mononucleotide/ubiquinol: a cocktail providing superior cardioprotection against ischemia/reperfusion injury in a common co-morbidities modelled rat
BackgroundThe metabolic and intracellular abnormalities in aging and diabetes cause loss of cardioprotection by routine interventions against...
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Germline specification from pluripotent stem cells
Reproduction is a key event in life guaranteeing the propagation and evolution of a species. Infertility caused by abnormal germ cell development is...
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MKK3 depletion attenuates intestinal injury after traumatic hemorrhagic shock by restoring mitochondrial function
BackgroundTraumatic hemorrhagic shock (THS) is a complex pathophysiological process resulting in multiple organ failure. Intestinal barrier...
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Infliximab Ameliorates Methotrexate-Induced Nephrotoxicity in Experimental Rat Model: Impact on Oxidative Stress, Mitochondrial Biogenesis, Apoptotic and Autophagic Machineries
Accumulating data confirms that Methotrexate (MTX), a well-known immunosuppressive and anticancer drug, causes nephrotoxicity. Infliximab (INF), the...
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UBE2T resolves transcription-replication conflicts and protects common fragile sites in primordial germ cells
The proper development of primordial germ cells (PGCs) is an essential prerequisite for gametogenesis and mammalian fertility. The Fanconi anemia...
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PGC-1α induced browning promotes involution and inhibits lactation in mammary glands
The PPARγ coactivator 1α (PGC-1α) is a transcriptional regulator of mitochondrial biogenesis and oxidative metabolism. Recent studies have...
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Coordinated transcriptional upregulation of oxidative metabolism proteins in long-lived endocrine mutant mice
Caloric restriction (CR), which extends lifespan in rodents, leads to increased hepatic fatty acid β-oxidation and oxidative phosphorylation...
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DNA methylation of exercise-responsive genes differs between trained and untrained men
BackgroundPhysical activity is well known for its multiple health benefits and although the knowledge of the underlying molecular mechanisms is...
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Chemical Genetics: Manipulating the Germline with Small Molecules
Primordial germ cells (PGCs) are the precursor cells that form during early embryogenesis and later differentiate into oocytes or spermatozoa....
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Role of oxidative stress and inflammation-related signaling pathways in doxorubicin-induced cardiomyopathy
Doxorubicin (DOX) is a powerful and commonly used chemotherapeutic drug, used alone or in combination in a variety of cancers, while it has been...
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Combination of nicotinamide mononucleotide and troxerutin induces full protection against doxorubicin-induced cardiotoxicity by modulating mitochondrial biogenesis and inflammatory response
BackgroundClinical application of doxorubicin (DOX) is restricted due to its cardiotoxicity, reinforcing the significance of exploring new strategies...
