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From Probiotics to Postbiotics: Key to Microbiome and Health
Humans are consuming probiotic microorganisms through traditionally fermented food since thousands of years, unknowingly. Probiotic microorganisms...
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Compositional changes in fecal microbiota in a new Parkinson's disease model: C57BL/6-Tg(NSE-haSyn) mice
BackgroundThe gut–brain axis (GBA) in Parkinson's disease (PD) has only been investigated in limited mice models despite dysbiosis of the gut...
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Neuroinflammation and galectins: a key relationship in neurodegenerative diseases
Neurodegeneration is a pathological condition that is associated with the loss of neuronal function and structure. In neurodegenerative diseases,...
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The Effect of Long-Term Emotional and Painful Stress on the Expression of Proinflammatory Cytokine Genes in Rats with High and Low Excitability of the Nervous System
AbstractStress plays an important role in the pathogenesis of anxiety and depressive disorders. Neuroinflammation is considered as one of the...
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An investigation of the anti-inflammatory effects of gabapentin on acetic acid-induced colitis in rats
Inflammatory bowel disease (IBD) is considered a chronic inflammatory gastrointestinal disease with treatment options which exhibit low efficacies...
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Role of Herbal Medicine in Boosting Immune System
Herbal medicines are the medicines obtained from plant sources. This is an alternate type of treatment based on traditional knowledge and scientific...
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Slc43a2+ T cell metastasis from spleen to brain in RGNNV infected teleost
The origin of T cells in the teleost’s brain is unclear. While viewing the central nervous system (CNS) as immune privileged has been widely...
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The Important Role of Systems Biology in Neuroscience and Neurology and Its Associated Diseases
Neurodegenerative diseases are a huge global health concern in the Western world due to our ageing population and other factors. Research into these...
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Rab11A Depletion in Microglia-Derived Extracellular Vesicle Proteome upon Beta-Amyloid Treatment
Microglia, the macrophage-like glial cells, behave as sentinels against exogenous pathogens invading the neural tissue. Their commitment is not only...
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Role of B cells and the aging brain in stroke recovery and treatment
As mitigation of brain aging continues to be a key public health priority, a wholistic and comprehensive consideration of the aging body has...
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Combining adoptive NK cell infusion with a dopamine-releasing peptide reduces senescent cells in aged mice
Aging inducing the development of senescent cells (SNCs) in various tissues is considered as the main cause of the age-related diseases. Senotherapy...
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Transcriptome-wide association study reveals increased neuronal FLT3 expression is associated with Tourette’s syndrome
Tourette’s Syndrome (TS) is a neurodevelopmental disorder that is characterized by motor and phonic tics. A recent TS genome-wide association study...
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Do malignant cells sleep at night?
Biological rhythms regulate the biology of most, if not all living creatures, from whole organisms to their constitutive cells, their microbiota, and...
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Human gut microbiome, diet, and mental disorders
Diet is one of the most important external factor sha** the composition and metabolic activities of the gut microbiome. The gut microbiome plays a...
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Arsenic Exposure Induces Neuro-immune Toxicity in the Cerebral Cortex and the Hippocampus via Neuroglia and NLRP3 Inflammasome Activation in C57BL/6 Mice
This study aimed to examine the immuntoxic effects of arsenic in the nervous system. Our results showed that arsenic increased corticocerebral and...
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Towards physiologically relevant human pluripotent stem cell (hPSC) models of Parkinson’s disease
The derivation of human embryonic stem cells followed by the discovery of induced pluripotent stem cells and leaps in genome editing approaches have...
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Identification of autophagy-related genes in neuropathic pain through bioinformatic analysis
BackgroundNeuropathic pain (NP) is one of the most common types of chronic pain and significantly compromises the quality of life. Autophagy is an...
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Role of Antimicrobial Peptides in Immunity of Parasitic Leeches
AbstractThe review summarizes the current state of knowledge about leech immunity, with emphasis on the special role of antimicrobial peptides...
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