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Challenges and mitigation strategies associated with Burkholderia cepacia complex contamination in pharmaceutical manufacturing
Burkholderia cepacia complex (BCC) is a Gram-negative, non-spore-forming bacterium with more than 20 opportunistic pathogenic species, most commonly...
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Biomolecule Integrated Nanostructures for Advanced Diagnosis Systems in Viral Disease Management of Crops
One of the crucial factors that confine crop productivity is plant disease and appropriate identification of pathogen under field condition in an...
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Transcriptome-wide identification of RNA-binding protein binding sites using seCLIP-seq
Discovery of interaction sites between RNA-binding proteins (RBPs) and their RNA targets plays a critical role in enabling our understanding of how...
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Single-Cell Sequencing Technology and Its Application in the Study of Central Nervous System Diseases
The mammalian central nervous system consists of a large number of cells, which contain not only different types of neurons, but also a large number...
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Next-Gen Nano Biosensor Technologies to Monitor Carbapenem Resistance for Personalized Medicine
Carbapenem resistance represents a pressing public health concern, posing significant challenges due to limited treatment options and escalating...
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Detection and Identification of Soil-Borne Pathogens: Classical to Recent Updates
Soil being biologically complex atmosphere offers shelter to diverse microbes. The survival of microbes in soil is greatly influenced by both edaphic...
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Integromics: Tracking the Multi-omic Expanse in Theragnostics
Complex diseases cause immense burden on health management systems, with potentially higher rates of late or wrong diagnosis leading to mortality....
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Advancements in Molecular Techniques for the Detection of Foodborne Pathogens
Advancements in the survival mechanisms of foodborne pathogens have confronted several challenges for the storage and preservation of food products,...
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Application of CRISPR–Cas Technology in Drug Development
The discovery of clustered regularly interspaced short palindromic repeat (CRISPR)-Cas technology has transformed the science of genome editing,...
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In Situ Analytical Tools to Resolve Stress Response Mechanisms of Foodborne Pathogens
In situ analytical techniques hold great potential for the investigation of stress response of foodborne pathogens, as they can provide unprecedented...
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Single-nucleoid architecture reveals heterogeneous packaging of mitochondrial DNA
Cellular metabolism relies on the regulation and maintenance of mitochondrial DNA (mtDNA). Hundreds to thousands of copies of mtDNA exist in each...
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Immune targeting of HIV-1 reservoir cells: a path to elimination strategies and cure
Successful approaches for eradication or cure of HIV-1 infection are likely to include immunological mechanisms, but remarkably little is known about...
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Mycoplasma and Ureaplasma
Several species of genera Mycoplasma and Ureaplasma have now become well-known human pathogens that are responsible for a wide range of diseases...
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Application of Forensic DNA Technology in Analyzing Real-Time Casework Samples
The French criminologist Edmond Locard developed what is now known as the Locard’s exchange principle, or “every contact leaves a trace,” in 1910...
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Quaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein
Parkinson’s disease (PD) and Multiple System Atrophy (MSA) are progressive and unremitting neurological diseases that are neuropathologically...
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Distinct colon mucosa microbiomes associated with tubular adenomas and serrated polyps
Colorectal cancer is the second most deadly and third most common cancer in the world. Its development is heterogenous, with multiple mechanisms of...
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Ligand-bound glutamine binding protein assumes multiple metastable binding sites with different binding affinities
Protein dynamics plays key roles in ligand binding. However, the microscopic description of conformational dynamics-coupled ligand binding remains a...
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Rapid detection of Chattonella marina by PCR combined with dot lateral flow strip
In this study a novel technique referred to as PCR combined with dot lateral flow strip (PCDS) is proposed and its application to the detection of...
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Neisseria lactamica Controlled Human Infection Model
Neisseria lactamica is a nonpathogenic commensal of the human upper respiratory tract that has been associated with protection against N....
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Nano-Bio-Analytical Systems for the Detection of Emerging Infectious Diseases
The global damage caused by the spreading microbial infection is evident from the devastating COVID-19 pandemic. The infectious diseases caused by...