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MELK promotes HCC carcinogenesis through modulating cuproptosis-related gene DLAT-mediated mitochondrial function
Cuproptosis caused by copper overload is mediated by a novel regulatory mechanism that differs from previously documented mechanisms regulating cell...
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Association between aging-related biomarkers and longitudinal trajectories of intrinsic capacity in older adults
Intrinsic capacity (IC), the composite of physical and mental capacities, declines with age at different rates and patterns between individuals. We...
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Isolation of Functional Mitochondria and Pure mtDNA from Murine Tissues
Detailed analysis of mitochondrial function cannot be achieved without good quality preparations of isolated mitochondria. Ideally, the isolation...
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Altered Lysosomal Function Manipulates Cellular Biosynthetic Capacity By Remodeling Intracellular Cholesterol Distribution
Lysosomes are known to influence cholesterol trafficking into endoplasmic reticulum (ER) membranes. Though intracellular cholesterol levels are known...
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Mitochondrial matrix-localized Src kinase regulates mitochondrial morphology
The architecture of mitochondria adapts to physiological contexts: while mitochondrial fragmentation is usually associated to quality control and...
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Emerging roles of mitochondrial functions and epigenetic changes in the modulation of stem cell fate
Mitochondria serve as essential organelles that play a key role in regulating stem cell fate. Mitochondrial dysfunction and stem cell exhaustion are...
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Endoplasmic reticulum stress induces mitochondrial dysfunction but not mitochondrial unfolded protein response in SH-SY5Y cells
In the present study we have shown that treatment of SH-SY5Y cells with either thapsigargin or tunicamycin is associated with a significant decrease...
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Mitochondrial genomes revisited: why do different lineages retain different genes?
The mitochondria contain their own genome derived from an alphaproteobacterial endosymbiont. From thousands of protein-coding genes originally...
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Impairment of substrate-mediated mitochondrial respiration in cardiac cells by chloroquine
Chloroquine (CQ) has a long clinical history as an anti-malarial agent and also being used for the treatment of other infections and autoimmune...
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Lack of detectable sex differences in the mitochondrial function of Caenorhabditis elegans
BackgroundSex differences in mitochondrial function have been reported in multiple tissue and cell types. Additionally, sex-variable responses to...
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Prefoldin 2 contributes to mitochondrial morphology and function
BackgroundPrefoldin is an evolutionarily conserved co-chaperone of the tailless complex polypeptide 1 ring complex (TRiC)/chaperonin containing...
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The centrosomal protein 131 participates in the regulation of mitochondrial apoptosis
Centriolar satellites are multiprotein aggregates that orbit the centrosome and govern centrosome homeostasis and primary cilia formation. In...
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Regulation with cell size ensures mitochondrial DNA homeostasis during cell growth
To maintain stable DNA concentrations, proliferating cells need to coordinate DNA replication with cell growth. For nuclear DNA, eukaryotic cells...
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Inhibition of Drp1- Fis1 interaction alleviates aberrant mitochondrial fragmentation and acute kidney injury
BackgroundAcute kidney injury (AKI) is a common clinical disorder with complex etiology and poor prognosis, and currently lacks specific and...
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HOMER3 promotes non-small cell lung cancer growth and metastasis primarily through GABPB1-mediated mitochondrial metabolism
Cancer metabolism has emerged as a major target for cancer therapy, while the state of mitochondrial drugs has remained largely unexplored, partly...
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Inherited myogenic abilities in muscle precursor cells defined by the mitochondrial complex I-encoding protein
Skeletal muscle comprises different muscle fibers, including slow- and fast-type muscles, and satellite cells (SCs), which exist in individual muscle...
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Knocking out Fkbp51 decreases CCl4-induced liver injury through enhancement of mitochondrial function and Parkin activity
Background and aimsPreviously, we found that FK506 binding protein 51 ( Fkbp51 ) knockout (KO) mice resist high fat diet-induced fatty liver and...
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The current insights of mitochondrial hormesis in the occurrence and treatment of bone and cartilage degeneration
It is widely acknowledged that aging, mitochondrial dysfunction, and cellular phenotypic abnormalities are intricately associated with the...
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Dimorphic effect of TFE3 in determining mitochondrial and lysosomal content in muscle following denervation
BackgroundMuscle atrophy is a common consequence of the loss of innervation and is accompanied by mitochondrial dysfunction. Mitophagy is the...
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Deoxycytidine kinase inactivation enhances gemcitabine resistance and sensitizes mitochondrial metabolism interference in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is considered one of the most lethal forms of cancer. Although in the last decade, an increase in 5-year...
