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Gut microbiome-derived ammonia modulates stress vulnerability in the host
Ammonia has been long recognized as a metabolic waste product with well-known neurotoxic effects. However, little is known about the beneficial...
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Identifying behaviour-related and physiological risk factors for suicide attempts in the UK Biobank
Suicide is a global public health challenge, yet considerable uncertainty remains regarding the associations of both behaviour-related and...
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Untargeted metabolomic analysis of metabolites related to body dysmorphic disorder (BDD)
Body dysmorphic disorder (BDD) is a disorder associated with depression and eating disorders. It often arises from minor defects in appearance or an...
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Metabolic communication during exercise
The coordination of nutrient sensing, delivery, uptake and utilization is essential for maintaining cellular, tissue and whole-body homeostasis. Such...
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Genetic analysis of dietary intake identifies new loci and functional links with metabolic traits
Dietary intake is a major contributor to the global obesity epidemic and represents a complex behavioural phenotype that is partially affected by...
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Late-onset depression is associated to age-related central auditory processing disorder in an older population in Southern Italy
The association between late-life depression (LLD) and age-related hearing loss (ARHL) was suggested by preliminary studies, but reliance on LLD...
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Metabolic Syndrome and Body Composition Among People Aged 50 Years and Over: Results from The Neyshabur Longitudinal Study on Ageing (NeLSA)
There are few studies regarding body composition and metabolic syndrome (MetS) association in older adults . To evaluate the association between MetS...
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Effects of Curcumin on Depression and Anxiety: A Narrative Review of the Recent Clinical Data
Depressive and anxiety disorders affect a significant proportion of the global population and constitute one of the highest disease burdens...
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Metabolic signatures of osteoarthritis in urine using liquid chromatography‐high resolution tandem mass spectrometry
IntroductionOsteoarthritis (OA) is a common cause of disability in older people, but its aetiology is not yet fully understood. Biomarkers of OA from...
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Curcumin-rich curry consumption and life expectancy: Singapore longitudinal ageing study
The therapeutic potential of curcumin for many diseases are intensively investigated. However, real-world observational data documenting health and...
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Molecular mechanisms of growth depression in broiler chickens (Gallus Gallus domesticus) mediated by immune stress: a hepatic proteome study
BackgroundImmunological stress decreases feed intake, suppresses growth and induces economic losses. However, the underlying molecular mechanism...
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Activation of oxytocinergic neurons enhances torpor in mice
Mus musculus enters a torpid state in response to caloric restriction in sub-thermoneutral ambient temperatures. This torpid state is characterized...
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Long-term physiological responses to combined ocean acidification and warming show energetic trade-offs in an asterinid starfish
While organismal responses to climate change and ocean acidification are increasingly documented, longer-term (> a few weeks) experiments with marine...
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Microbial and metabolomic profiles in correlation with depression and anxiety co-morbidities in diarrhoea-predominant IBS patients
BackgroundPsychological co-morbidities in irritable bowel syndrome (IBS) have been widely recognized, whereas less is known regarding the role of gut...
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The Effects of Probiotic and Selenium Co-supplementation on Clinical and Metabolic Scales in Chronic Schizophrenia: a Randomized, Double-blind, Placebo-Controlled Trial
This study evaluated the effects of probiotic and selenium co-supplementation on clinical and metabolic symptoms in patients with chronic...
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Epigenetics and the Extreme Stress Response
Environmental conditions can be highly unfavorable for many organisms, imposing a variety of extreme stresses onto animal inhabitants. Winters are...
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Flexible energy-saving strategies in female temperate-zone bats
Torpor is characterized by an extreme reduction in metabolism and a common energy-saving strategy of heterothermic animals. Torpor is often...
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P2X7 receptor mediates NLRP3 inflammasome activation in depression and diabetes
The increasing prevalence of depression and diabetes mellitus has become a major public health problem worldwide. Studies have shown that people with...
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Metabolic characteristics of overwintering by the high-altitude dwelling **zang plateau frog, Nanorana parkeri
The **zang plateau frog, Nanorana parkeri , has the highest altitudinal distribution of all frogs in the world and survives the cold of winter without...
