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Interplay Between n-3 and n-6 Long-Chain Polyunsaturated Fatty Acids and the Endocannabinoid System in Brain Protection and Repair
The brain is enriched in arachidonic acid (ARA) and docosahexaenoic acid (DHA), long-chain polyunsaturated fatty acids (LCPUFAs) of the n-6 and n-3...
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Cannabinoid exposure during pregnancy and its impact on immune function
Cannabinoids are the most commonly abused illicit drugs worldwide. While cannabis can be beneficial for certain heath conditions, abuse of potent...
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Lipases: An Overview
Lipases are ubiquitous enzymes, widespread in nature. They were first isolated from bacteria in the early nineteenth century, and the associated...
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Case Study for Trait-Related Gene Evolution: Oil Biosynthesis Genes
Brassica napus was formed through recent hybridization between Brassica oleracea and Brassica rapa and is an important source of edible oil. The...
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Changes in lipids composition and metabolism in colorectal cancer: a review
Altered metabolism of lipids is currently considered a hallmark characteristic of many malignancies, including colorectal cancer (CRC). Lipids are a...
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Comparison of Hematopoietic and Spermatogonial Stem Cell Niches from the Regenerative Medicine Aspect
Recent advances require a dual evaluation of germ and somatic stem cell niches with a regenerative medicine perspective. For a better point of view...
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Cannabinoids as Regulators of Neural Development and Adult Neurogenesis
Neurogenesis plays an indispensable role in the formation of the nervous system during development. The discovery that the adult brain still...
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Female Mice are Resistant to Fabp1 Gene Ablation-Induced Alterations in Brain Endocannabinoid Levels
Although liver fatty acid binding protein (FABP1, L-FABP) is not detectable in the brain, Fabp1 gene ablation (LKO) markedly increases...
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Gut microbiota as a potential target of metabolic syndrome: the role of probiotics and prebiotics
Metabolic syndrome (MS) comprises central obesity, increased plasma glucose levels, hyperlipidemia and hypertension, and its incidence is increasing...
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The Role of Monoacylglycerol Lipase (MAGL) in the Cancer Progress
In recent years, metabolism is talked highly important in cancer research, especially the lipid metabolism. Researchers believe that the de novo...
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Fatty Acid Binding Protein-1 (FABP1) and the Human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias
The first discovered member of the mammalian FABP family, liver fatty acid binding protein (FABP1, L-FABP), occurs at high cytosolic concentration in...
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Role of the Endocannabinoid System in Hepatic Lipogenesis
Endocannabinoids are endogenous lipid mediators recognized by the cannabinoid-1 and 2 (CB1 and CB2, respectively) receptors that mediate the effects...
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Brain 2-Arachidonoylglycerol Levels Are Dramatically and Rapidly Increased Under Acute Ischemia-Injury Which Is Prevented by Microwave Irradiation
The involvement of brain 2-arachidonoylglycerol (2-AG) in a number of critical physiological and pathophysiological regulatory mechanisms highlights...
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Glycerol-3-phosphate acyltransferase-1 upregulation by O-GlcNAcylation of Sp1 protects against hypoxia-induced mouse embryonic stem cell apoptosis via mTOR activation
Oxygen signaling is critical for stem cell regulation, and oxidative stress-induced stem cell apoptosis decreases the efficiency of stem cell...
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Fate Through Fat: Neutral Lipids as Regulators of Neural Stem Cells
Lipids constitute the majority of the brain’s dry mass, yet little is known about their influences on neural stem cell (NSC) biology during...
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Transcriptome analysis revealed the dynamic oil accumulation in Symplocos paniculata fruit
BackgroundSymplocos paniculata , asiatic sweetleaf or sapphire berry, is a widespread shrub or small tree from Symplocaceae with high oil content and...
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An in vivo multiplexed small-molecule screening platform
Phenotype-based small-molecule screening is a powerful method to identify molecules that regulate cellular functions. However, such screens are...
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Plate-based diversity subset screening generation 2: an improved paradigm for high-throughput screening of large compound files
High-throughput screening (HTS) is an effective method for lead and probe discovery that is widely used in industry and academia to identify novel...
