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Salinity Tolerance and Seasonal and Multiyear Dynamics of Biting Midges (Diptera, Ceratopogonidae) in Macrozoobenthos Communities of Saline Rivers (the Lake Elton Basin, Russia)
AbstractThe results of long-term studies of biting midges (Diptera, Ceratopogonidae) in macrozoobenthos communities of five saline rivers of the...
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Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p
Male reproductive diseases are becoming increasingly prominent, and sperm quality is an important indicator to reflect these diseases. Seminal plasma...
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BCAT2 promotes melanoma progression by activating lipogenesis via the epigenetic regulation of FASN and ACLY expressions
Melanoma is the most lethal skin cancer originating from the malignant transformation of epidermal melanocyte. The dysregulation of cellular...
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Deciphering the Role of Exosomal Non-Coding RNA (ncRNA) in Drug Resistance of Gastrointestinal Tumors; an Updated Review
One of the most prevalent types of cancer worldwide today is gastric intestinal (GI) tumors. To guarantee their lives, people with a developed GI...
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Mesenchymal stem cell-derived extracellular vesicles in therapy against fibrotic diseases
Fibrosis is likely to occur in many tissues and organs to induce cicatrisation and dysfunction. The therapeutic regimens for delaying and even...
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MicroRNA in lung cancer—a novel potential way for early diagnosis and therapy
Lung cancer is the most common cause of cancer-related deaths in the world. One of the reasons of poor prognosis and high mortality of lung cancer...
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Current insight into the functions of microRNAs in common human hair loss disorders: a mini review
Alopecia areata (AA) and Androgenic alopecia (AGA) are the most common multifactorial hair loss disorders that have a serious psychological impact on...
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Genome-wide association study reveals the genetic basis controlling mineral accumulation in wheat grains under potassium deficiency
Potassium deficit might affect the accumulation of macronutrients in wheat grains that are crucial to plant health, growth, yield, and quality....
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BMPMDA: Prediction of MiRNA-Disease Associations Using a Space Projection Model Based on Block Matrix
With the high-quality development of bioinformatics technology, miRNA-disease associations (MDAs) are gradually being uncovered. At present,...
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Modification of BCLX pre-mRNA splicing has antitumor efficacy alone or in combination with radiotherapy in human glioblastoma cells
Dysregulation of anti-apoptotic and pro-apoptotic protein isoforms arising from aberrant splicing is a crucial hallmark of cancers and may contribute...
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A comprehensive molecular profiling approach reveals metabolic alterations that steer bone tissue regeneration
Bone regeneration after fracture is a complex process with high and dynamic energy demands. The impact of metabolism on bone healing progression and...
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Extracellular vesicles derived from LPS-preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and prevent osteoarthritis of the knee in a mouse model
BackgroundPrevious studies report that lipopolysaccharide (LPS)-preconditioned mesenchymal stem cells have enhanced trophic support and improved...
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Controlling the Immune Response to Zebrafish Spinal Cord Injury via Extracellular Vesicles Secreted by Activated Monocyte-like Cells
AbstractThe immune response to spinal cord injury (SCI) is implemented via local and systemic inflammation, followed by repair and...
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mir-98-5p regulates gluconeogenesis and lipogenesis by targeting PPP1R15B in hepatocytes
Several reports suggest that circulatory miRNAs are deregulated in diverse diseases and used as markers for disease diagnosis and prognosis. Here we...
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Analysis of Mitochondrial DNA Replication by Two-Dimensional Agarose Gel Electrophoresis
Two-dimensional neutral/neutral agarose gel electrophoresis (2D-AGE) has been employed for nearly two decades in the analysis of replication and...
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FlowCam 8400 and FlowCam Cyano Phytoplankton Classification and Viability Staining by Imaging Flow Cytometry
This chapter provides a protocol for a detailed evaluation of phytoplankton and nuisance cyanobacteria with the FlowCam 8400 and the FlowCam Cyano....
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The functions and potential roles of extracellular vesicle noncoding RNAs in gynecological malignancies
Extracellular vesicles (EVs) are small membranous vesicles secreted by multiple kinds of cells and are widely present in human body fluids. EVs...
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The Role of miR-150-5p/SOCS1 Pathway in Arsenic-Induced Pyroptosis of LX-2 Cells
This study aims to explore the mechanism of pyroptosis of human hepatocyte LX-2 cells induced by NaAsO 2 through the miR-150-5p/SOCS1 pathway. LX-2...
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Measuring criticality in control of complex biological networks
Recent controllability analyses have demonstrated that driver nodes tend to be associated to genes related to important biological functions as well...
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Experimental and numerical study on the mechanical behavior of curved glulam structures
In order to investigate the mechanical behavior of curved glulam structures, five-point bending tests were conducted on three typical glulam...
