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William Bateson: A biologist ahead of his time
William Bateson coined the term genetics and, more than anybody else, championed the principles of heredity discovered by Gregor Mendel....
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The nematode Caenorhabditis elegans as a model to study the roles of proteoglycans
The nematode Caenorhabditis elegans is a powerful animal model for exploring the genetic basis of metazoan development. Recent genetic and...
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Where does our behaviour come from?
Looking for single causes, whether genetic or environmental, may yield answers of a kind, but little sense of what happens as each individual grows...
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Autosomal and X-Linked Auditory Disorders
Our conceptual thinking about hearing is confined, in part, by the “deafness” genes that have and have not identified. The proper development of the...
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The WFDC1 gene encoding ps20 localizes to 16q24, a region of LOH in multiple cancers
We previously identified ps20 protein as a secreted growth inhibitor and purified the protein from fetal rat prostate urogenital sinus mesenchymal...
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Current cases in which epitope mimicry is considered as a component cause of autoimmune disease: immune-mediated (type 1) diabetes
Autoimmune diseases result from a combination of genetic, immunologic, hormonal, and environmental factors. Infectious agents may induce the...
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Evolution of chromosome Y in primates
We have investigated, by fluorescence in situ hybridization (FISH), the cytogenetic evolution of the Y chromosome in primates using 17 yeast...
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The immunoglobulin superfamily: An insight on its tissular, species, and functional diversity
The immunoglobulin superfamily (IgSF) is a heterogenic group of proteins built on a common fold, called the Ig fold, which is a sandwich of two ßp...
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Extensive Direct-Tandem Organization of a Long Repeat DNA Sequence on the Y Chromosome of Chinook Salmon (
Oncorhynchus tshawytscha )A long repetitive DNA sequence (OtY8) has been cloned from male chinook salmon and its genomic organization has been characterized. The repeat has a...
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Renewing olfactory receptor neurons in goldfish do not require contact with the olfactory bulb to develop normal chemical responsiveness
This study investigated whether contact with the olfactory bulb was necessary for develo** and renewing olfactory receptor neurons (ORNs) to...
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Exon Detection by Similarity Searches
Other chapters of this volume have presented the various experimental methods (mainly exon trap** and recombination-based and hybridization-based...
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Comparative map** of Xp22 genes in hominoids – evolutionary linear instability of their Y homologues
Several genes located within or proximal to the human PAR in Xp22 have homologues on the Y chromosome and escape, or partly escape, inactivation. To...
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Human Gene Therapy
The term human gene therapy is defined as the transfer of DNA or RNA into human cells for therapeutic purposes. Significant advancements in...
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Behavioral Genetics: Research Strategies and Examples
Scope and Conceptual Difficulties of Human Behavior Genetics. A survey of the genetic aspects of evolution shows great similarity...
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Formal Genetics of Humans: Multifactorial Inheritance and Common Diseases
The paradigm that resulted from Mendel’s work with pea crosses (Sect.1.4) has since developed in several steps to the level of the gene in its...
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Genetic intervention in human beings
Various aspects of human biology and medicine will be influenced by the information provided by the Human Genome Project regarding the entire human...
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Molecular Basis of Genetic Disorders of Pigmentation in Humans and Mice
Disorders of pigmentation were among the first genetic diseases recognized in humans. The distinctive phenotypes of oculocutaneous albinism (OCA) and...
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Rapid evolution of human pseudoautosomal genes and their mouse homologs
Comparative studies of genes in the pseudoautosomal region (PAR) of human and mouse sex chromosomes have thus far been very limited. The only...
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Cell Adhesion
The central role of cell adhesion in multicellular organisms is self-evident. In order to form functional tissues, cells must physically adhere to...